{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:30:41Z","timestamp":1788780641682,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022ZD15"],"award-info":[{"award-number":["ZR2022ZD15"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["2022-N-02-13"],"award-info":[{"award-number":["2022-N-02-13"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Nature Science Foundation","award":["82070800"],"award-info":[{"award-number":["82070800"]}]},{"name":"Taishan Scholars Program of Shandong Province","award":["tstp20231250"],"award-info":[{"award-number":["tstp20231250"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1004801-2"],"award-info":[{"award-number":["2022YFA1004801-2"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Given the high heterogeneity of type 2 diabetes mellitus (T2DM), it is imperative to develop personalized stem cell infusion regimen for targeted metabolic phenotype in order to ensure optimal therapeutic efficacy. In this study, we conducted a comparative analysis of 4 infusion regimens involving single and repeated infusions of human umbilical cord Wharton\u2019s jelly-derived MSCs (hucMSCs), single infusions of umbilical cord blood mononuclear cells (UCB), and sequential infusions of hucMSCs and UCB in T2DM rats. Results showed all 4 infusion regimens exhibited comparable efficacy in lowering fasting blood glucose levels and suppressing glucagon secretion. Single and double infusions of hucMSCs exhibited a tendency to migrate to the liver, thereby better at ameliorating hepatic glucose metabolism by enhancing glycogen synthesis and storage, promoting glycolysis, inhibiting gluconeogenesis, and improving insulin signal transduction. The sequential infusion of hucMSCs and UCB demonstrated specific cell tropism toward the pancreas, leading to prolonged glucose-lowering effects following a glucose tolerance test, restoration of early-phase insulin secretion, stimulation of islet beta cell proliferation and improvement in the beta\/alpha ratio. Multiple injections, regardless of cell type, reduced the expression of systemic chronic inflammatory markers such as IL-1\u03b2, IL-6, IL-17, IL-22, and IFN-\u03b3. Finally, a single dose of UCB exhibited a greater tendency to target visceral fat and enhanced effectiveness in regulating levels of total cholesterol and triglycerides. In conclusion, our study provided personalized stem cell regimens for diverse T2DM metabolic phenotypes, thereby offering improved treatment alternatives for future clinical trials and applications.<\/jats:p>","DOI":"10.1093\/stcltm\/szae083","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:33:18Z","timestamp":1732033998000},"source":"Crossref","is-referenced-by-count":1,"title":["Tailoring cell therapies for diabetic metabolic phenotypes: a comparative study on the efficacy of various umbilical cord-derived cell regimens"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6692-1408","authenticated-orcid":false,"given":"Lingshu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]},{"name":"Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases, Shandong Provincial Engineering Research Center for Advanced Technologies in Prevention and Treatment of Chromic Metabolic Diseases, Institute of Endocrine and Metabolic Diseases of Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falian","family":"He","sequence":"additional","affiliation":[{"name":"Postdoctoral Innovation Base, Novolife Biomedical Technology Co., LTD , Tai\u2019an 271000, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital , Tianjin, 300052 ,\u00a0","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]},{"name":"Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases, Shandong Provincial Engineering Research Center for Advanced Technologies in Prevention and Treatment of Chromic Metabolic Diseases, Institute of Endocrine and Metabolic Diseases of Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8062","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]},{"name":"Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases, Shandong Provincial Engineering Research Center for Advanced Technologies in Prevention and Treatment of Chromic Metabolic Diseases, Institute of Endocrine and Metabolic Diseases of Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Qilu Hospital, Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]},{"name":"Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases, Shandong Provincial Engineering Research Center for Advanced Technologies in Prevention and Treatment of Chromic Metabolic Diseases, Institute of Endocrine and Metabolic Diseases of Shandong University , Jinan 250012, Shandong ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2025031212374615000_CIT0001","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S2213-8587(23)00223-1","article-title":"Emerging Risk Factors Collaboration. 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