{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:15:07Z","timestamp":1790792107842,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Periodontitis is an inflammation of the alveolar bone and soft tissue surrounding the teeth. Although mesenchymal stem cells (MSCs) have been implicated in periodontal regeneration, the mechanisms by which they promote osteogenesis remain unclear. We examined whether epigenetic modifications mediated by the long-noncoding RNA (lncRNA) NR_045147, which plays a crucial role in cancer, influence the osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Alkaline phosphatase staining, alizarin red staining, and western blotting were used to detect the effects of NR_045147 on PDLSC osteogenic differentiation. Scratch migration and transwell chemotaxis assays were used to evaluate the effects of NR_045147 on PDLSC migration. Mitochondrial function was evaluated via Seahorse XF analysis to measure changes in cellular respiration upon manipulation of NR_045147 expression. Ubiquitination assays were performed to examine the protein stability and degradation pathways affected by the NR_045147\u2013MDM2 interaction. An in vivo nude rat calvarial defect model was established and gene-edited PDLSCs were re-implanted to examine the osteogenic effects of NR_045147. NR_045147 significantly reduced PDLSC osteogenic differentiation and migration ability both in vitro and in vivo. Under inflammatory conditions, the loss of NR_045147 rescued osteogenesis. NR_045147 significantly blocked the expression of integrin beta3-binding protein (ITGB3BP). Mechanistically, NR_045147 promoted the ITGB3BP-MDM2 interaction, thus increasing ITGB3BP ubiquitination and degradation. NR_045147 regulated PDLSC mitochondrial respiration and ITGB3BP upregulation efficiently promoted their osteogenic differentiation and migration ability. Concluding, NR_045147 downregulation enhances PDLSC osteogenic differentiation and migration, connects changes in cellular metabolism to functional outcomes via mitochondrial respiration, and promotes ITGB3BP degradation by mediating its interaction with MDM2.<\/jats:p>","DOI":"10.1093\/stcltm\/szae088","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T01:06:27Z","timestamp":1734224787000},"source":"Crossref","is-referenced-by-count":7,"title":["LncRNA NR_045147 modulates osteogenic differentiation and migration in PDLSCs via ITGB3BP degradation and mitochondrial dysfunction"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-9991","authenticated-orcid":false,"given":"Lujue","family":"Long","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology , Beijing ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology , Beijing ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengquan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Changsha Stomatology Hospital , Changsha, Hunan ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University , Changsha, Hunan ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology , Beijing ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Fan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology , Beijing ,","place":["People\u2019s Republic of China"]},{"name":"Beijing Laboratory of Oral Health, Capital Medical University , Beijing ,","place":["People\u2019s Republic of China"]},{"name":"Research Unit of Tooth Development and Regeneration, Chinese Academy of Medical Sciences , Beijing ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"key":"2025031212374505500_CIT0001","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1056\/NEJM197105132841906","article-title":"Periodontal disease","volume":"284","author":"Glickman","year":"1971","journal-title":"N Engl J Med"},{"key":"2025031212374505500_CIT0002","doi-asserted-by":"publisher","first-page":"1151322","DOI":"10.3389\/fimmu.2023.1151322","article-title":"The role of extracellular vesicles in periodontitis: pathogenesis, diagnosis, and therapy","volume":"14","author":"Cai","year":"2023","journal-title":"Front Immunol"},{"key":"2025031212374505500_CIT0003","volume-title":"Periodontal Disease","author":"Gasner","year":"2024"},{"key":"2025031212374505500_CIT0004","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.prosdent.2021.11.001","article-title":"Association between obstructive sleep apnea and periodontitis in Chinese male adults: a cross-sectional study","volume":"130","author":"Chen","year":"2023","journal-title":"J Prosthet Dent"},{"key":"2025031212374505500_CIT0005","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/prd.12435","article-title":"Viruses, periodontitis, and comorbidities","volume":"89","author":"Teles","year":"2022","journal-title":"Periodontol 2000"},{"key":"2025031212374505500_CIT0006","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int Dent J"},{"key":"2025031212374505500_CIT0007","doi-asserted-by":"publisher","first-page":"102070","DOI":"10.1016\/j.tice.2023.102070","article-title":"Exosomes derived from mesenchymal stem cells: heralding a new treatment for periodontitis","volume":"82","author":"Mousavi","year":"2023","journal-title":"Tissue Cell"},{"key":"2025031212374505500_CIT0008","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3390\/cells8060537","article-title":"Periodontal bone-ligament-cementum regeneration via scaffolds and stem cells","volume":"8","author":"Liu","year":"2019","journal-title":"Cells"},{"key":"2025031212374505500_CIT0009","doi-asserted-by":"publisher","first-page":"36","DOI":"10.7150\/ijms.21666","article-title":"Ethical and safety issues of stem cell-based therapy","volume":"15","author":"Volarevic","year":"2018","journal-title":"Int J Med Sci"},{"key":"2025031212374505500_CIT0010","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/scd.2019.0031","article-title":"Periodontal ligament stem cells: regenerative potency in periodontium","volume":"28","author":"Tomokiyo","year":"2019","journal-title":"Stem Cells Dev"},{"key":"2025031212374505500_CIT0011","doi-asserted-by":"publisher","first-page":"e49437","DOI":"10.7759\/cureus.49437","article-title":"Implications of gene therapy in dentistry and periodontics: a narrative review","volume":"15","author":"Barhate","year":"2023","journal-title":"Cureus"},{"key":"2025031212374505500_CIT0012","doi-asserted-by":"publisher","first-page":"e202009045","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J Cell Biol"},{"key":"2025031212374505500_CIT0013","doi-asserted-by":"publisher","first-page":"108912","DOI":"10.1016\/j.biopha.2019.108912","article-title":"Mesenchymal stem cell-associated lncRNA in osteogenic differentiation","volume":"115","author":"Ju","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"2025031212374505500_CIT0014","doi-asserted-by":"publisher","first-page":"5671809","DOI":"10.1155\/2023\/5671809","article-title":"lncRNA CYTOR facilitates osteogenic differentiation of human periodontal ligament stem cells by modulating SOX11 via sponging miR-6512-3p","volume":"2023","author":"Tu","year":"2023","journal-title":"Stem Cells Int"},{"key":"2025031212374505500_CIT0015","doi-asserted-by":"publisher","first-page":"110285","DOI":"10.1016\/j.cellsig.2022.110285","article-title":"Mechanical force-sensitive lncRNA SNHG8 inhibits osteogenic differentiation by regulating EZH2 in hPDLSCs","volume":"93","author":"Zhang","year":"2022","journal-title":"Cell Signal"},{"key":"2025031212374505500_CIT0016","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41413-022-00197-x","article-title":"LncRNA GACAT2 binds with protein PKM1\/2 to regulate cell mitochondrial function and cementogenesis in an inflammatory environment","volume":"10","author":"Li","year":"2022","journal-title":"Bone Res"},{"key":"2025031212374505500_CIT0017","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/jre.12962","article-title":"LncRNA LOXL1-AS1 inhibits proliferation of PDLSCs and downregulates IL-1\u03b2 in periodontitis patients","volume":"57","author":"Ruan","year":"2022","journal-title":"J Periodontal Res"},{"key":"2025031212374505500_CIT0018","first-page":"1","article-title":"Periodontal wound healing and regeneration","volume":"19","year":"1999","journal-title":"Periodontol 2000"},{"key":"2025031212374505500_CIT0019","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41421-022-00439-6","article-title":"Structural insights into human CCAN complex assembled onto DNA","volume":"8","author":"Tian","year":"2022","journal-title":"Cell Discov"},{"key":"2025031212374505500_CIT0020","doi-asserted-by":"publisher","first-page":"712","DOI":"10.17305\/bjbms.2021.5690","article-title":"Integrated profiling identifies ITGB3BP as prognostic biomarker for hepatocellular carcinoma","volume":"21","author":"Liang","year":"2021","journal-title":"Bosn J Basic Med Sci"},{"key":"2025031212374505500_CIT0021","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bbrc.2021.06.008","article-title":"\u03b23-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis","volume":"566","author":"Cao","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"2025031212374505500_CIT0022","doi-asserted-by":"publisher","first-page":"317853","DOI":"10.1155\/2014\/317853","article-title":"Comparison of long noncoding RNA and mRNA expression profiles in mesenchymal stem cells derived from human periodontal ligament and bone marrow","volume":"2014","author":"Dong","year":"2014","journal-title":"Biomed Res Int"},{"key":"2025031212374505500_CIT0023","doi-asserted-by":"publisher","first-page":"9603271221080236","DOI":"10.1177\/09603271221080237","article-title":"Effect of nano zinc oxide on proliferation and toxicity of human gingival cells","volume":"41","author":"Chen","year":"2022","journal-title":"Hum Exp Toxicol"},{"key":"2025031212374505500_CIT0024","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41586-020-2188-x","article-title":"A reference map of the human binary protein interactome","volume":"580","author":"Luck","year":"2020","journal-title":"Nature"},{"key":"2025031212374505500_CIT0025","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/joor.12843","article-title":"The therapeutic role of bone marrow stem cell local injection in rat experimental periodontitis","volume":"47","author":"Lu","year":"2020","journal-title":"J Oral Rehabil"},{"key":"2025031212374505500_CIT0026","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bioactmat.2024.02.011","article-title":"Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation","volume":"35","author":"Liu","year":"2024","journal-title":"Bioact Mater"},{"key":"2025031212374505500_CIT0027","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1111\/odi.14491","article-title":"Epigenetic regulation of osteogenic differentiation of periodontal ligament stem cells in periodontitis","volume":"29","author":"Cao","year":"2023","journal-title":"Oral Dis"},{"key":"2025031212374505500_CIT0028","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1515\/biol-2022-0474","article-title":"Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments","volume":"17","author":"Jin","year":"2022","journal-title":"Open Life Sci"},{"key":"2025031212374505500_CIT0029","doi-asserted-by":"publisher","first-page":"7951","DOI":"10.1080\/21655979.2022.2051690","article-title":"Effects of nuclear factor-\u03baB signaling pathway on periodontal ligament stem cells under lipopolysaccharide-induced inflammation","volume":"13","author":"Chen","year":"2022","journal-title":"Bioengineered"},{"key":"2025031212374505500_CIT0030","doi-asserted-by":"publisher","first-page":"eabl5716","DOI":"10.1126\/sciadv.abl5716","article-title":"NGF-p75 signaling coordinates skeletal cell migration during bone repair","volume":"8","author":"Xu","year":"2022","journal-title":"Sci Adv"},{"key":"2025031212374505500_CIT0031","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1093\/abbs\/gmab086","article-title":"TNF-\u03b1 inhibits fibrosis and migration of fibroblasts in hypertrophic scar by miR-141-3p","volume":"53","author":"Zhou","year":"2021","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"2025031212374505500_CIT0032","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s13287-020-01704-9","article-title":"Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing","volume":"11","author":"Guo","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"2025031212374505500_CIT0033","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.it.2017.08.005","article-title":"Tissue-specific immunity at the oral mucosal barrier","volume":"39","author":"Moutsopoulos","year":"2018","journal-title":"Trends Immunol"},{"key":"2025031212374505500_CIT0034","doi-asserted-by":"publisher","first-page":"28","DOI":"10.5507\/bp.2021.066","article-title":"Periodontitis association with IL-8 gene polymorphisms","volume":"166","author":"Kriauciunas","year":"2022","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"2025031212374505500_CIT0035","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3897\/folmed.62.e47722","article-title":"Presence of IL-8 gene polymorphism and IL-8 serum levels in patients with chronic periodontitis\u2014literature review","volume":"62","author":"Mlachkova","year":"2020","journal-title":"Folia Med (Plovdiv)"},{"key":"2025031212374505500_CIT0036","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/jcmm.17127","article-title":"ITGB3BP is a potential biomarker associated with poor prognosis of glioma","volume":"26","author":"Liu","year":"2022","journal-title":"J Cell Mol Med"},{"key":"2025031212374505500_CIT0037","doi-asserted-by":"publisher","first-page":"14215","DOI":"10.1038\/s41598-019-50794-w","article-title":"Acquisition of a side population fraction augments malignant phenotype in ovarian cancer","volume":"9","author":"Yamanoi","year":"2019","journal-title":"Sci Rep"},{"key":"2025031212374505500_CIT0038","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.bbrc.2021.08.029","article-title":"CRISPR\/Cas9-mediated gene editing on Sox2ot promoter leads to its truncated expression and does not influence neural tube closure and embryonic development in mice","volume":"573","author":"Li","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"2025031212374505500_CIT0039","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1038\/s41467-021-24774-6","article-title":"The upstream 5\u02b9 splice site remains associated to the transcription machinery during intron synthesis","volume":"12","author":"Leader","year":"2021","journal-title":"Nat Commun"},{"key":"2025031212374505500_CIT0040","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.7150\/thno.83920","article-title":"The interplay between non-coding RNAs and alternative splicing: from regulatory mechanism to therapeutic implications in cancer","volume":"13","author":"Liu","year":"2023","journal-title":"Theranostics"},{"key":"2025031212374505500_CIT0041","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2019.04.011","article-title":"Long non-coding RNA: classification, biogenesis and functions in blood cells","volume":"112","author":"Dahariya","year":"2019","journal-title":"Mol Immunol"},{"key":"2025031212374505500_CIT0042","doi-asserted-by":"publisher","first-page":"13578","DOI":"10.3390\/ijms222413578","article-title":"Pathogenesis of autoimmune hepatitis-cellular and molecular mechanisms","volume":"22","author":"Sirbe","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025031212374505500_CIT0043","first-page":"348","article-title":"beta(3)-Integrin cytoplasmic binding proteins","volume":"52","author":"Zhao","year":"2004","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"2025031212374505500_CIT0044","doi-asserted-by":"publisher","first-page":"751301","DOI":"10.3389\/fcell.2021.751301","article-title":"Extracellular matrix signals as drivers of mitochondrial bioenergetics and metabolic plasticity of cancer cells during metastasis","volume":"9","author":"Urra","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2025031212374505500_CIT0045","doi-asserted-by":"publisher","first-page":"114856","DOI":"10.18632\/oncotarget.23145","article-title":"Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-\u03b2 signaling and malignant features in vitro and in vivo","volume":"8","author":"Ses\u00e9","year":"2017","journal-title":"Oncotarget"},{"key":"2025031212374505500_CIT0046","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.tcm.2008.11.003","article-title":"Foxc2 transcription factor: a newly described regulator of angiogenesis","volume":"18","author":"Kume","year":"2008","journal-title":"Trends Cardiovasc Med"},{"key":"2025031212374505500_CIT0047","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1089\/ars.2013.5286","article-title":"The \u03b23-integrin binding protein \u03b23-endonexin is a novel negative regulator of hypoxia-inducible factor-1","volume":"20","author":"Kra\u010dun","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"2025031212374505500_CIT0048","doi-asserted-by":"publisher","first-page":"mjac051","DOI":"10.1093\/jmcb\/mjac051","article-title":"Phosphorylation of CENP-R by Aurora B regulates kinetochore-microtubule attachment for accurate chromosome segregation","volume":"14","author":"Sedzro","year":"2022","journal-title":"J Mol Cell Biol"},{"key":"2025031212374505500_CIT0049","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3390\/metabo13101064","article-title":"Inhibition of GCN2 reveals synergy with cell-cycle regulation and proteostasis","volume":"13","author":"Gauthier-Coles","year":"2023","journal-title":"Metabolites"},{"key":"2025031212374505500_CIT0050","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/cbf.2837","article-title":"P-glycoprotein (ABCB1) inhibited network of mitochondrion transport along microtubule and BMP signal-induced cell shape in chimpanzee left cerebrum by systems-theoretical analysis","volume":"30","author":"Lin","year":"2012","journal-title":"Cell Biochem Funct"},{"key":"2025031212374505500_CIT0051","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1006\/bbrc.1999.2007","article-title":"beta3-endonexin as a novel inhibitor of cyclin A-associated kinase","volume":"267","author":"Ohtoshi","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"2025031212374505500_CIT0052","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00436-015-4344-z","article-title":"Anti-Eimeria activity of berberine and identification of associated gene expression changes in the mouse jejunum infected with Eimeria papillata","volume":"114","author":"Dkhil","year":"2015","journal-title":"Parasitol Res"},{"key":"2025031212374505500_CIT0053","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12884-017-1270-3","article-title":"Research on the expression of integrin \u03b23 and leukaemia inhibitory factor in the decidua of women with cesarean scar pregnancy","volume":"17","author":"Qian","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025031212374505500_CIT0054","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1111\/cas.13348","article-title":"CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model","volume":"108","author":"Okumura","year":"2017","journal-title":"Cancer Sci"},{"key":"2025031212374505500_CIT0055","doi-asserted-by":"publisher","first-page":"e1204","DOI":"10.1002\/ctm2.1204","article-title":"The roles of E3 ubiquitin ligases in cancer progression and targeted therapy","volume":"13","author":"Sampson","year":"2023","journal-title":"Clin Transl Med"},{"key":"2025031212374505500_CIT0056","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12929-019-0569-y","article-title":"Ubiquitin-mediated regulation of autophagy","volume":"26","author":"Chen","year":"2019","journal-title":"J Biomed Sci"},{"key":"2025031212374505500_CIT0057","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3390\/ijms21031151","article-title":"Expanding role of ubiquitin in translational control","volume":"21","author":"Dougherty","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025031212374505500_CIT0058","doi-asserted-by":"publisher","first-page":"e1900171","DOI":"10.1002\/bies.201900171","article-title":"Ubiquitin signaling regulates RNA biogenesis, processing, and metabolism","volume":"42","author":"Thapa","year":"2020","journal-title":"Bioessays"},{"key":"2025031212374505500_CIT0059","doi-asserted-by":"publisher","first-page":"105253","DOI":"10.1016\/j.neuint.2021.105253","article-title":"Non-coding RNAs: New players in mitophagy and neurodegeneration","volume":"152","author":"Tai","year":"2022","journal-title":"Neurochem Int"},{"key":"2025031212374505500_CIT0060","doi-asserted-by":"publisher","first-page":"1335519","DOI":"10.3389\/fimmu.2024.1335519","article-title":"Crosstalk between ubiquitin ligases and ncRNAs drives cardiovascular disease progression","volume":"15","author":"You","year":"2024","journal-title":"Front Immunol"},{"key":"2025031212374505500_CIT0061","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.yexcr.2005.02.003","article-title":"Proteolysis leads to the appearance of the long form of beta3-endonexin in human platelets","volume":"305","author":"Sadoul","year":"2005","journal-title":"Exp Cell Res"},{"key":"2025031212374505500_CIT0062","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.7150\/thno.81847","article-title":"Role of p53 in breast cancer progression: an insight into p53 targeted therapy","volume":"13","author":"Marvalim","year":"2023","journal-title":"Theranostics"},{"key":"2025031212374505500_CIT0063","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.bbamcr.2019.01.012","article-title":"Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts","volume":"1866","author":"Daniele","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2025031212374505500_CIT0064","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.bcp.2018.10.032","article-title":"MDM2 and mitochondrial function: one complex intersection","volume":"162","author":"Rubio-Pati\u00f1o","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"2025031212374505500_CIT0065","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41590-021-00888-3","article-title":"The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity","volume":"22","author":"Zhou","year":"2021","journal-title":"Nat Immunol"},{"key":"2025031212374505500_CIT0066","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1038\/s41598-020-61796-4","article-title":"Mdm2 enhances ligase activity of parkin and facilitates mitophagy","volume":"10","author":"Kook","year":"2020","journal-title":"Sci Rep"},{"key":"2025031212374505500_CIT0067","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.molcel.2019.02.012","article-title":"MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network","volume":"74","author":"Elkholi","year":"2019","journal-title":"Mol Cell"},{"key":"2025031212374505500_CIT0068","doi-asserted-by":"publisher","first-page":"16226","DOI":"10.3390\/ijms150916226","article-title":"Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration","volume":"15","author":"Wang","year":"2014","journal-title":"Int J Mol Sci"},{"key":"2025031212374505500_CIT0069","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2023.03.032","article-title":"Insight into the effect of biomaterials on osteogenic differentiation of mesenchymal stem cells: a review from a mitochondrial perspective","volume":"164","author":"Feng","year":"2023","journal-title":"Acta Biomater"},{"key":"2025031212374505500_CIT0070","doi-asserted-by":"publisher","first-page":"1077058","DOI":"10.3389\/fendo.2023.1077058","article-title":"Mitochondrial quality control and its role in osteoporosis","volume":"14","author":"Yan","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025031212374505500_CIT0071","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fcell.2019.00355","article-title":"Mitochondrial involvement in migration, invasion and metastasis","volume":"7","author":"Denisenko","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"2025031212374505500_CIT0072","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s12272-021-01360-4","article-title":"Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis","volume":"44","author":"Huynh","year":"2021","journal-title":"Arch Pharm Res"},{"key":"2025031212374505500_CIT0073","doi-asserted-by":"publisher","first-page":"101559","DOI":"10.1016\/j.bbrep.2023.101559","article-title":"Antioxidant and anti-inflammatory effects of selenomethionine promote osteogenesis via Wnt\/\u03b2-Catenin pathway","volume":"36","author":"Zhao","year":"2023","journal-title":"Biochem Biophys Rep"},{"key":"2025031212374505500_CIT0074","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1002\/jcp.30729","article-title":"Mitochondria-actin cytoskeleton crosstalk in cell migration","volume":"237","author":"Yadav","year":"2022","journal-title":"J Cell Physiol"},{"key":"2025031212374505500_CIT0075","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41577-022-00760-x","article-title":"Mitochondrial control of inflammation","volume":"23","author":"Marchi","year":"2023","journal-title":"Nat Rev Immunol"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/14\/2\/szae088\/61184043\/szae088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/14\/2\/szae088\/61184043\/szae088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T12:38:02Z","timestamp":1741783082000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/doi\/10.1093\/stcltm\/szae088\/7924201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,14]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,11]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szae088","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,12,14]]},"article-number":"szae088"}}