{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:55:58Z","timestamp":1791042958302,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN143316"],"award-info":[{"award-number":["FDN143316"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000098","name":"Stem Cell Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Necrotizing enterocolitis (NEC) remains an incurable gut complication of prematurity with significant morbidity and mortality. Cell therapies, including mesenchymal stromal cells (MSCs), may be a promising treatment given their anti-inflammatory and regenerative potential. We assessed the effect of MSCs and other cell therapies (not classified as MSCs) on incidence, severity, and mortality in preclinical models of NEC. Bibliographic and gray literature searches yielded 17 371 records with 107 full-text articles assessed and ultimately 16 studies were included. These studies featured only rodents NEC models via combination of hyperosmolar feeds, hypoxia, hypothermia, or lipopolysaccharides. Ten studies used interventions with MSCs. Only 2 met the minimal criteria to define MSCs proposed by the International Society for Cell &amp; Gene Therapy (ISCT). The overall risk of bias was assessed as high partly due to paucity of data with important gaps in reporting, reinforcing the importance of rigorous research framework, appropriate cell-therapy and outcome reporting in preclinical research. A reduction in the incidence of NEC (odds ratio [OR] 0.32, 95% CI [0.17, 0.62]), severe NEC (OR 0.30, 95% CI [0.18, 0.50]), and mortality (OR 0.30, 95% CI [0.16, 0.55]) was noted with MSCs treatment, seemingly more pronounced for ISCT-defined (ISCT+) MSCs. Amniotic fluid stem cells, neural stem cells, and placenta stem cells also showed a reduction in these measures. Given their accessibility (ie, umbilical cord) and proven safety profile in extremely preterm infants, our analysis provides a foundation for considering MSCs as promising candidate that requires further evaluation for the treatment of NEC.<\/jats:p>","DOI":"10.1093\/stcltm\/szae102","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:23:08Z","timestamp":1735629788000},"source":"Crossref","is-referenced-by-count":10,"title":["Cell-based therapies in preclinical models of necrotizing enterocolitis: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"14","author":[{"given":"Camille","family":"Maltais-Bilodeau","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario , Ottawa, ON K1H 8L1 ,\u00a0","place":["Canada"]},{"name":"Department of Obstetrics, Gynecology\u00a0and Newborn Care, The Ottawa Hospital, General Campus , Ottawa, ON K1H 8L6 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,\u00a0","place":["Canada"]},{"name":"Department of Obstetrics, Gynecology\u00a0and Newborn Care, The Ottawa Hospital, General Campus , Ottawa, ON K1H 8L6 ,\u00a0","place":["Canada"]},{"name":"Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 ,","place":["Canada"]},{"name":"Faculty of Medicine, University of Ottawa , Ottawa, ON K1H 8M5 ,\u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flore","family":"Lesage","sequence":"additional","affiliation":[{"name":"Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-1686","authenticated-orcid":false,"given":"Kelly D","family":"Cobey","sequence":"additional","affiliation":[{"name":"Meta Research and Open Science Program, University of Ottawa Heart Institute , Ottawa, ON K1Y 4W7 ,\u00a0","place":["Canada"]},{"name":"School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa , Ottawa, ON K1H 8M5 ,\u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadera","family":"Ahmadzai","sequence":"additional","affiliation":[{"name":"Independent Information\u00a0Specialist , Ottawa, ON K1T 3Z2 ,\u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Skidmore","sequence":"additional","affiliation":[{"name":"Independent Information\u00a0Specialist , Ottawa, ON K1T 3Z2 ,\u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario , Ottawa, ON K1H 8L1 ,\u00a0","place":["Canada"]},{"name":"Department of Obstetrics, Gynecology\u00a0and Newborn Care, The Ottawa Hospital, General Campus , Ottawa, ON K1H 8L6 ,\u00a0","place":["Canada"]},{"name":"Faculty of Medicine, University of Ottawa , Ottawa, ON K1H 8M5 ,\u00a0","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1844-7145","authenticated-orcid":false,"given":"Bernard","family":"Th\u00e9baud","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Children\u2019s Hospital of Eastern Ontario , Ottawa, ON K1H 8L1 ,\u00a0","place":["Canada"]},{"name":"Department of Obstetrics, Gynecology\u00a0and Newborn Care, The Ottawa Hospital, General Campus , Ottawa, ON K1H 8L6 ,\u00a0","place":["Canada"]},{"name":"Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 ,","place":["Canada"]},{"name":"Faculty of Medicine, University of Ottawa , Ottawa, ON K1H 8M5 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