{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:54:49Z","timestamp":1780361689053,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","award":["DGE-1553798"],"award-info":[{"award-number":["DGE-1553798"]}],"id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130436"],"award-info":[{"award-number":["R01HL130436"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011866","name":"Colorado Clinical and Translational Sciences Institute","doi-asserted-by":"publisher","award":["5TL1TR002533-02"],"award-info":[{"award-number":["5TL1TR002533-02"]}],"id":[{"id":"10.13039\/100011866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007180","name":"Children\u2019s Hospital Colorado","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007180","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gates Institute for Regenerative Medicine"},{"DOI":"10.13039\/100008081","name":"Dystrophic Epidermolysis Bullosa Research Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008081","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gates Grubstake Fund"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 AR074642"],"award-info":[{"award-number":["R21 AR074642"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maximizing Access to Research Careers \u2013 Undergraduate Student Training in Academic Research","award":["T34 GM096958"],"award-info":[{"award-number":["T34 GM096958"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Importance:\u00a0Amniotic fluid is a promising source of autologous cells for disease modeling, drug screening, and regenerative medicine applications. However, current methods of collecting amniotic fluid are invasive, and samples are limited to pregnancies that require amniocentesis or cesarean section. Objective:\u00a0The purpose of this study was to determine whether amniotic fluid cells could be isolated and cultured from amniotic fluid collected during vaginal deliveries. Intervention:\u00a0Amniotic fluid samples were obtained during delivery of 4 neonates, 3 of which had been prenatally diagnosed with hypoplastic left heart syndrome (HLHS) in utero. Adherent amniotic fluid cells were assessed for maternal cell contamination, proliferation rate, surface marker expression, and differentiation potential. Amniotic fluid cells were also reprogrammed to induced pluripotent stem cells (iPSCs) and differentiated into functional cardiomyocytes. Results: Amniotic fluid cells collected from vaginal deliveries showed similar surface marker phenotype and differentiation characteristics to amniotic fluid-derived mesenchymal stem cells collected from amniocentesis and cesarean section. Amniotic fluid cells collected during vaginal births of both neonates with HLHS and one neonate with typical heart geometry could be reprogrammed to iPSCs and differentiated to a cardiac lineage with high efficiency. Conclusions and Relevence:\u00a0These findings suggest that amniotic fluid collected from vaginal births is a readily available source of patient-specific stem cells for banking, in vitro disease modeling, and regenerative medicine applications.<\/jats:p>","DOI":"10.1093\/stcltm\/szaf017","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T12:19:41Z","timestamp":1750853981000},"source":"Crossref","is-referenced-by-count":2,"title":["Amniotic fluid collected from vaginal birth as a source of stem cells for clinical applications and disease modeling"],"prefix":"10.1093","volume":"14","author":[{"given":"Mallory L","family":"Lennon","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Frieman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Colorado School of Medicine, Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa K","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kogut","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Colorado School of Medicine, Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Bilousova","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Colorado School of Medicine, Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-5055","authenticated-orcid":false,"given":"Jeffrey G","family":"Jacot","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Colorado Anschutz Medical Campus , Aurora, CO 80045 ,","place":["United States"]},{"name":"Department of Pediatrics, Children\u2019s Hospital Colorado , Aurora, CO 80045 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2025062508193505100_CIT0001","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/sj.jp.7211290","article-title":"Amniotic fluid: not just fetal urine anymore","volume":"25","author":"Underwood","year":"2005","journal-title":"J Perinatol"},{"key":"2025062508193505100_CIT0002","first-page":"106","article-title":"Origin of cells in human amniotic fluid cultures: ultrastructural features","volume":"39","author":"Priest","year":"1978","journal-title":"Lab Invest"},{"key":"2025062508193505100_CIT0003","first-page":"137","article-title":"The diagnosis of sex before birth using cells from the amniotic fluid (a preliminary report)","volume":"5B","author":"Serr","year":"1955","journal-title":"Bull Res Counc Isr"},{"key":"2025062508193505100_CIT0004","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1053\/jpsu.2001.27945","article-title":"The amniotic fluid as a source of cells for fetal tissue engineering","volume":"36","author":"Kaviani","year":"2001","journal-title":"J Pediatr Surg"},{"key":"2025062508193505100_CIT0005","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1182\/blood-2003-04-1291","article-title":"Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation","volume":"102","author":"In \u2032t Anker","year":"2003","journal-title":"Blood"},{"issue":"suppl","key":"2025062508193505100_CIT0006","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/978-3-7091-6721-2_21","article-title":"Stem cell marker expression in human trisomy 21 amniotic fluid cells and trophoblasts","volume":"67","author":"Prusa","year":"2003","journal-title":"J Neural Transm Suppl"},{"key":"2025062508193505100_CIT0007","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1093\/humrep\/deh279","article-title":"Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol","volume":"19","author":"Tsai","year":"2004","journal-title":"Hum Reprod"},{"key":"2025062508193505100_CIT0008","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/nbt1274","article-title":"Isolation of amniotic stem cell lines with potential for therapy","volume":"25","author":"De Coppi","year":"2007","journal-title":"Nat Biotechnol"},{"key":"2025062508193505100_CIT0009","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/uog.14636","article-title":"Procedure-related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta-analysis","volume":"45","author":"Akolekar","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2025062508193505100_CIT0010","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.ijgo.2008.06.012","article-title":"Isolation of human mesenchymal stem cells from third-trimester amniotic fluid","volume":"103","author":"You","year":"2008","journal-title":"Int J Gynaecol Obstet"},{"key":"2025062508193505100_CIT0011","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3233\/RNN-2011-0620","article-title":"Third trimester amniotic fluid cells with the capacity to develop neural phenotypes and with heterogeneity among sub-populations","volume":"30","author":"Bottai","year":"2012","journal-title":"Restor Neurol Neurosci"},{"key":"2025062508193505100_CIT0012","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600549","article-title":"Full-thickness heart repair with an engineered multilayered myocardial patch in rat model","volume":"6","author":"Pok","year":"2017","journal-title":"Adv Healthc Mater"},{"key":"2025062508193505100_CIT0013","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s13287-017-0582-6","article-title":"Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications","volume":"8","author":"Moraghebi","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"2025062508193505100_CIT0014","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.ajog.2018.05.035","article-title":"Human term amniotic fluid: a novel source of stem cells for regenerative medicine","volume":"219","author":"Dolin","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2025062508193505100_CIT0015","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4137\/BMI.S20058","article-title":"Stem cells and progenitor cells for tissue-engineered solutions to congenital heart defects","volume":"10","author":"Gao","year":"2015","journal-title":"Biomark Insights"},{"key":"2025062508193505100_CIT0016","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4161\/org.22426","article-title":"CD117(+) amniotic fluid stem cells: state of the art and future perspectives","volume":"8","author":"Cananzi","year":"2012","journal-title":"Organogenesis"},{"key":"2025062508193505100_CIT0017","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1089\/scd.2010.0424","article-title":"Amniotic fluid stem cells are cardioprotective following acute myocardial infarction","volume":"20","author":"Bollini","year":"2011","journal-title":"Stem Cells Dev"},{"key":"2025062508193505100_CIT0018","doi-asserted-by":"publisher","first-page":"e2101018","DOI":"10.1002\/adhm.202101018","article-title":"A prevascularized polyurethane-reinforced fibrin patch improves regenerative remodeling in a rat right ventricle replacement model","volume":"10","author":"Tao","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"2025062508193505100_CIT0019","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s12015-010-9200-z","article-title":"In vitro and in vivo cardiomyogenic differentiation of amniotic fluid stem cells","volume":"7","author":"Bollini","year":"2011","journal-title":"Stem Cell Rev Rep"},{"key":"2025062508193505100_CIT0020","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.yjmcc.2006.12.008","article-title":"Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat","volume":"42","author":"Chiavegato","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"2025062508193505100_CIT0021","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/term.308","article-title":"In vitro cardiomyogenic potential of human amniotic fluid stem cells","volume":"5","author":"Guan","year":"2011","journal-title":"J Tissue Eng Regen Med"},{"key":"2025062508193505100_CIT0022","doi-asserted-by":"publisher","first-page":"E1848","DOI":"10.1073\/pnas.1200250109","article-title":"Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling","volume":"109","author":"Lian","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025062508193505100_CIT0023","doi-asserted-by":"publisher","first-page":"034103","DOI":"10.1088\/1748-6041\/10\/3\/034103","article-title":"Amniotic fluid-derived stem cells demonstrate limited cardiac differentiation following small molecule-based modulation of Wnt signaling pathway","volume":"10","author":"Connell","year":"2015","journal-title":"Biomed Mater"},{"key":"2025062508193505100_CIT0024","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/s41420-019-0143-0","article-title":"The biochemical and electrophysiological profiles of amniotic fluid-derived stem cells following Wnt signaling modulation cardiac differentiation","volume":"5","author":"Liu","year":"2019","journal-title":"Cell Death Discov"},{"key":"2025062508193505100_CIT0025","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0091-679X(08)00005-8","article-title":"Characterization of human amniotic fluid stem cells and their pluripotential capability","volume":"86","author":"Perin","year":"2008","journal-title":"Methods Cell Biol"},{"key":"2025062508193505100_CIT0026","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3233\/RNN-2011-0620","article-title":"Third trimester amniotic fluid cells with the capacity to develop neural phenotypes and with heterogeneity among sub-populations","volume":"30","author":"Bottai","year":"2012","journal-title":"Restor Neurol Neurosci"},{"key":"2025062508193505100_CIT0027","doi-asserted-by":"publisher","first-page":"4101-8","DOI":"10.1007\/s11033-013-2494-6","article-title":"The effect of myostatin silencing by lentiviral-mediated RNA interference on goat fetal fibroblasts","volume":"40","author":"Lu","year":"2013","journal-title":"Mol Biol Rep"},{"key":"2025062508193505100_CIT0028","doi-asserted-by":"publisher","first-page":"416","DOI":"10.5966\/sctm.2013-0105","article-title":"An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes","volume":"3","author":"Jiang","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"2025062508193505100_CIT0029","doi-asserted-by":"publisher","first-page":"e0177824","DOI":"10.1371\/journal.pone.0177824","article-title":"Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells","volume":"12","author":"Velasquez-Mao","year":"2017","journal-title":"PLoS One"},{"key":"2025062508193505100_CIT0030","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1089\/cell.2009.0077","article-title":"Amniotic fluid cells are more efficiently reprogrammed to pluripotency than adult cells","volume":"12","author":"Galende","year":"2010","journal-title":"Cell Reprogramming"},{"key":"2025062508193505100_CIT0031","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s12195-015-0407-6","article-title":"Effect of passage, sorting, and media on differentiation capacity and marker expression in amniotic fluid stem cells","volume":"9","author":"Connell","year":"2016","journal-title":"Cell Mol Bioeng"},{"key":"2025062508193505100_CIT0032","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1089\/ten.TEA.2018.0054","article-title":"Controlled release of small molecules for cardiac differentiation of pluripotent stem cells","volume":"24","author":"Tsao","year":"2018","journal-title":"Tissue Eng Part A"},{"key":"2025062508193505100_CIT0033","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1089\/ten.TEA.2023.0201","article-title":"Bioreactor design for culturing vascularized engineered tissue in flow conditions","volume":"30","author":"Ibarra","year":"2024","journal-title":"Tissue Eng Part A"},{"key":"2025062508193505100_CIT0034","doi-asserted-by":"publisher","first-page":"107596","DOI":"10.1016\/j.mtcomm.2023.107596","article-title":"An in vitro characterization of a PCL-fibrin scaffold for myocardial repair","volume":"37","author":"Jarrell","year":"2023","journal-title":"Mater Today Commun"},{"key":"2025062508193505100_CIT0035","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/jbm.a.37662","article-title":"Vascularization of PEGylated fibrin hydrogels increases the proliferation of human iPSC-cardiomyocytes","volume":"112","author":"Vanderslice","year":"2024","journal-title":"J Biomed Mater Res A"},{"key":"2025062508193505100_CIT0036","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s12195-023-00791-x","article-title":"Trisomy 21 alters cell proliferation and migration of iPSC-derived cardiomyocytes on type VI collagen","volume":"17","author":"Reeser","year":"2024","journal-title":"Cell Mol Bioeng"},{"key":"2025062508193505100_CIT0037","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41467-018-03190-3","article-title":"High-efficiency RNA-based reprogramming of human primary fibroblasts","volume":"9","author":"Kogut","year":"2018","journal-title":"Nat Commun"},{"key":"2025062508193505100_CIT0038","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.stem.2009.08.001","article-title":"Hypoxia enhances the generation of induced pluripotent stem cells","volume":"5","author":"Yoshida","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2025062508193505100_CIT0039","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.matbio.2016.06.006","article-title":"Crystallographic analysis of the laminin beta2 short arm reveals how the LF domain is inserted into a regular array of LE domains","volume":"57-58","author":"Pulido","year":"2017","journal-title":"Matrix Biol"},{"key":"2025062508193505100_CIT0040","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.3390\/cells11243955","article-title":"Polymerized laminin-521: a feasible substrate for expanding induced pluripotent stem cells at a low protein concentration","volume":"11","author":"Mesquita","year":"2022","journal-title":"Cells"},{"issue":"141","key":"2025062508193505100_CIT0041","doi-asserted-by":"publisher","first-page":"10.3791\/58687","DOI":"10.3791\/58687","article-title":"RNA-based reprogramming of human primary fibroblasts into induced pluripotent stem cells","author":"McGrath","journal-title":"J Vis Exp"},{"key":"2025062508193505100_CIT0042","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1681\/ASN.2011010106","article-title":"Generation of induced pluripotent stem cells from urine","volume":"22","author":"Zhou","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2025062508193505100_CIT0043","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat Methods"},{"issue":"15 Aug","key":"2025062508193505100_CIT0044","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.yjmcc.2015.05.003","article-title":"Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories","volume":"85","author":"Hwang","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"2025062508193505100_CIT0045","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1080\/14767058.2016.1240162","article-title":"Prevalence of maternal cell contamination in amniotic fluid samples","volume":"30","author":"Weida","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025062508193505100_CIT0046","doi-asserted-by":"publisher","first-page":"319238","DOI":"10.1155\/2015\/319238","article-title":"Human amniotic fluid mesenchymal stem cells from second- and third-trimester amniocentesis: differentiation potential, molecular signature, and proteome analysis","volume":"2015","author":"Savickiene","year":"2015","journal-title":"Stem Cells Int"},{"key":"2025062508193505100_CIT0047","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"2025062508193505100_CIT0048","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13287-018-0864-7","article-title":"The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time","volume":"9","author":"Rahman","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"2025062508193505100_CIT0049","doi-asserted-by":"publisher","first-page":"21.3.1-21.3.15","DOI":"10.1002\/0471142905.hg2103s87","article-title":"Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells","volume":"87","author":"Burridge","year":"2015","journal-title":"Curr Protoc Hum Genet"},{"key":"2025062508193505100_CIT0050","doi-asserted-by":"publisher","first-page":"e102796","DOI":"10.1371\/journal.pone.0102796","article-title":"Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome","volume":"9","author":"Kobayashi","year":"2014","journal-title":"PLoS One"},{"key":"2025062508193505100_CIT0051","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nprot.2012.150","article-title":"Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt\/beta-catenin signaling under fully defined conditions","volume":"8","author":"Lian","year":"2013","journal-title":"Nat Protocols"},{"key":"2025062508193505100_CIT0052","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1161\/CIRCRESAHA.110.227512","article-title":"Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview","volume":"111","author":"Mummery","year":"2012","journal-title":"Circ Res"},{"key":"2025062508193505100_CIT0053","doi-asserted-by":"publisher","first-page":"1900344","DOI":"10.1002\/advs.201900344","article-title":"3D printing of personalized thick and perfusable cardiac patches and hearts","volume":"6","author":"Noor","year":"2019","journal-title":"Adv Sci (Weinh)"},{"key":"2025062508193505100_CIT0054","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1113\/JP278839","article-title":"Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability","volume":"598","author":"Dries","year":"2020","journal-title":"J Physiol"},{"key":"2025062508193505100_CIT0055","doi-asserted-by":"publisher","first-page":"714008","DOI":"10.3389\/fmolb.2022.714008","article-title":"Temporal control of the WNT signaling pathway during cardiac differentiation impacts upon the maturation state of human pluripotent stem cell derived cardiomyocytes","volume":"9","author":"Tsoi","year":"2022","journal-title":"Front Mol Biosci"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/14\/7\/szaf017\/63579181\/szaf017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/14\/7\/szaf017\/63579181\/szaf017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T12:19:42Z","timestamp":1750853982000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/doi\/10.1093\/stcltm\/szaf017\/8173631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szaf017","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,6,25]]},"article-number":"szaf017"}}