{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T19:40:17Z","timestamp":1758742817205,"version":"3.44.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Career Development","award":["23CDA1038803"],"award-info":[{"award-number":["23CDA1038803"]}]},{"DOI":"10.13039\/100019607","name":"Stanford Cardiovascular Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AR069395"],"award-info":[{"award-number":["U01AR069395"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR072613"],"award-info":[{"award-number":["R01AR072613"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR074458"],"award-info":[{"award-number":["R01AR074458"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA268514"],"award-info":[{"award-number":["R01 CA268514"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0343"],"award-info":[{"award-number":["W81XWH-20-1-0343"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-22-1-0189"],"award-info":[{"award-number":["W81XWH-22-1-0189"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>One in ten Americans carry a lifetime risk of ischemic heart failure, the most severe form of ischemic heart disease. Carrying a nearly 50% five\u2011year mortality rate, no interventional therapy exists to treat the underlying cause, microvascular malperfusion. In efforts to combat microvascular malperfusion, our group has utilized synergistic application of endothelial progenitor cells (EPCs) and smooth muscle cells (SMCs) to induce angiogenesis in ischemic myocardium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cells are then embedded into a rapidly manufacturable compressed collagen (CC) patch to provide a biosimilar scaffold ready for transplantation. The performance of the cellular compressed collagen patch was then tested on a rodent acute myocardial infarction model of ischemic heart failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>By post\u2011transplantation Day 28, the cellular CC patch improved left ventricular ejection fraction when compared to an acellular CC patch and control (cellular: 49.1 \u00b1 1.8%; acellular: 38.0 \u00b1 2.6%; control: 39.2 \u00b1 2.1%; ANOVA P\u2009=\u2009.0006). Cellular CC patch transplantation also induced mature angiogenesis as shown by arteriolar density (cellular: 1084 \u00b1 98 \u03b1SMA+vWF+\/mm2; acellular: 338 \u00b1 57 \u03b1SMA+vWF+\/mm2; control: 449 \u00b1 39 \u03b1SMA+vWF+\/mm2; ANOVA P = .0003) and vascular maturation index (cellular: 0.67 \u00b1 0.04; acellular: 0.48 \u00b1 0.02; and control: 0.46 \u00b1 0.04, P\u2009=\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In conclusion, transplantation of a rapidly manufacturable EPC\u2011SMC\u2011based compressed collagen patch effectively rescues myocardial function by enhancing neovascularization and attenuating post\u2011infarction myocardial injury.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/stcltm\/szaf035","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:09:47Z","timestamp":1752746987000},"source":"Crossref","is-referenced-by-count":0,"title":["Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy"],"prefix":"10.1093","volume":"14","author":[{"given":"Eric","family":"Pfrender","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kawago","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umayr","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gentaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-9883","authenticated-orcid":false,"given":"Yuanjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-335X","authenticated-orcid":false,"given":"Kenzo","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedsina","family":"Moeinzadeh","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayme","family":"Koltsov","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C","family":"Wu","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-492X","authenticated-orcid":false,"given":"Y Joseph","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Bioengineering, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip C","family":"Yang","sequence":"additional","affiliation":[{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhi P","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Bioengineering, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Department of Materials Science and Engineering, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-1273","authenticated-orcid":false,"given":"Yasuhiro","family":"Shudo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]},{"name":"Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA 94305,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"2025092415012144800_szaf035-B1","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.cardfail.2023.07.006","article-title":"Heart failure epidemiology and outcomes statistics: a report of the heart failure society of america","volume":"29","author":"Bozkurt","year":"2023","journal-title":"J Card Fail"},{"key":"2025092415012144800_szaf035-B2","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics\u20142023 update: a report from the American heart association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B3","doi-asserted-by":"publisher","first-page":"e026943","DOI":"10.1161\/JAHA.122.026943Weir","article-title":"Myocardial revascularization in patients with ischemic cardiomyopathy: for whom and how","volume":"12","author":"Liga","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2025092415012144800_szaf035-B4","doi-asserted-by":"publisher","first-page":"13F","DOI":"10.1016\/j.amjcard.2006.03.005","article-title":"Epidemiology of heart failure and left ventricular systolic dysfunction after acute myocardial infarction: Prevalence, clinical characteristics, and prognostic importance","volume":"97","author":"Weir","year":"2006","journal-title":"Am J Cardiol"},{"key":"2025092415012144800_szaf035-B5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1093\/bmb\/ldw059","article-title":"Stem cell therapy for ischemic heart diseases","volume":"121","author":"Yu","year":"2017","journal-title":"Br Med Bull"},{"key":"2025092415012144800_szaf035-B6","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1161\/01.CIR.0000118496.44135.A7","article-title":"Impact of microvascular dysfunction on left ventricular remodeling and Long-Term clinical outcome after primary coronary angioplasty for acute myocardial infarction","volume":"109","author":"Bolognese","year":"2004","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11886-021-01442-1","article-title":"Predictors of microvascular reperfusion after myocardial infarction","volume":"23","author":"Doherty","year":"2021","journal-title":"Curr Cardiol Rep"},{"key":"2025092415012144800_szaf035-B8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau1168","article-title":"Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium","volume":"11","author":"Saha","year":"2019","journal-title":"Sci Transl Med"},{"key":"2025092415012144800_szaf035-B9","doi-asserted-by":"publisher","first-page":"e002391","DOI":"10.1161\/CIRCINTERVENTIONS.115.002391","article-title":"Intracoronary delivery of Self-Assembling Heart-Derived microtissues (cardiospheres) for prevention of adverse remodeling in a pig model of convalescent myocardial infarction","volume":"8","author":"Gallet","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"2025092415012144800_szaf035-B10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.healun.2021.04.010","article-title":"Therapeutic efficacy of large aligned cardiac tissue derived from induced pluripotent stem cell in a porcine ischemic cardiomyopathy model","volume":"40","author":"Suzuki","year":"2021","journal-title":"J Heart Lung Transpl"},{"key":"2025092415012144800_szaf035-B11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.hlc.2010.06.1056","article-title":"Acute myocardial rescue with endogenous endothelial progenitor cell therapy","volume":"19","author":"Atluri","year":"2010","journal-title":"Heart Lung Circ"},{"key":"2025092415012144800_szaf035-B12","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.3727\/096368911X627462","article-title":"Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function","volume":"21","author":"Beitnes","year":"2012","journal-title":"Cell Transplant"},{"key":"2025092415012144800_szaf035-B13","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1161\/CIRCULATIONAHA.112.000293","article-title":"Spatially oriented, temporally sequential smooth muscle cell-endothelial progenitor cell bi-level cell sheet neovascularizes ischemic myocardium","volume":"128","author":"Shudo","year":"2013","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B14","doi-asserted-by":"publisher","first-page":"5631","DOI":"10.3390\/ijms22115631","article-title":"Dual stem cell therapy improves the myocardial recovery post-\u00adinfarction through reciprocal modulation of cell functions","volume":"22","author":"Popescu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025092415012144800_szaf035-B15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S1522-1865(03)00082-9","article-title":"Transplantation of endothelial progenitor cells for therapeutic neovascularization","volume":"3","author":"Kawamoto","year":"2002","journal-title":"Cardiovasc Radiat Med"},{"key":"2025092415012144800_szaf035-B16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/cells9081886","article-title":"The state of art of regenerative therapy in cardiovascular ischemic disease: Biology, signaling pathways, and epigenetics of endothelial progenitor cells","volume":"9","author":"Perrotta","year":"2020","journal-title":"Cells"},{"key":"2025092415012144800_szaf035-B17","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: an update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transplant"},{"key":"2025092415012144800_szaf035-B18","doi-asserted-by":"publisher","first-page":"17605","DOI":"10.1038\/s41598-022-21510-y","article-title":"Angiogenic stem cell delivery platform to augment Post-Infarction neovasculature and reverse ventricular remodeling","volume":"12","author":"Shin","year":"2022","journal-title":"Sci Rep"},{"key":"2025092415012144800_szaf035-B19","doi-asserted-by":"publisher","first-page":"ehw056","DOI":"10.1093\/eurheartj\/ehw056","article-title":"Intramyocardial stem cell injection: go(ne) with the flow","volume":"38","author":"Van Den Akker","year":"2017","journal-title":"Eur Heart J"},{"key":"2025092415012144800_szaf035-B20","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1161\/CIRCULATIONAHA.112.000368","article-title":"Normalization of postinfarct biomechanics using a novel tissue-engineered angiogenic construct","volume":"128","author":"Atluri","year":"2013","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B21","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jtcvs.2017.04.081","article-title":"Layered smooth muscle cell-endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function","volume":"154","author":"Shudo","year":"2017","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025092415012144800_szaf035-B22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1161\/CIRCHEARTFAILURE.113.001273","article-title":"A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy","volume":"7","author":"Cohen","year":"2014","journal-title":"Circ Heart Fail"},{"key":"2025092415012144800_szaf035-B23","doi-asserted-by":"publisher","first-page":"100098","DOI":"10.1016\/j.mtbio.2021.100098","article-title":"A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities","volume":"10","author":"Sarrigiannidis","year":"2021","journal-title":"Mater Today Bio"},{"key":"2025092415012144800_szaf035-B24","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/jcp.20270","article-title":"Smart materials as scaffolds for tissue engineering","volume":"203","author":"Rosso","year":"2005","journal-title":"J Cell Physiol"},{"key":"2025092415012144800_szaf035-B25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jcp.10471","article-title":"From cell-ECM interactions to tissue engineering","volume":"199","author":"Rosso","year":"2004","journal-title":"J Cell Physiol"},{"key":"2025092415012144800_szaf035-B26","first-page":"180","article-title":"Evaluating the effect of pH on mechanical strength and cell compatibility of nanostructured collagen hydrogel by the plastic compression method","volume":"5","author":"Karimizade","year":"2018","journal-title":"Nanomed J"},{"key":"2025092415012144800_szaf035-B27","doi-asserted-by":"publisher","first-page":"1804943","DOI":"10.1002\/adfm.201804943","article-title":"Advanced Collagen-Based biomaterials for regenerative biomedicine","volume":"29","author":"Lin","year":"2019","journal-title":"Adv Funct Materials"},{"key":"2025092415012144800_szaf035-B28","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1002\/adfm.200500042","article-title":"Ultrarapid engineering of biomimetic materials and tissues: Fabrication of nano- and microstructures by plastic compression","volume":"15","author":"Brown","year":"2005","journal-title":"Adv Funct Materials"},{"key":"2025092415012144800_szaf035-B29","first-page":"1863","article-title":"Collagen-based biomaterials for tissue engineering applications","volume":"3","author":"Parenteau-Bareil","year":"2010","journal-title":"Mater Basel"},{"key":"2025092415012144800_szaf035-B30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s10856-006-0685-1","article-title":"Effect of multiple unconfined compression on cellular dense collagen scaffolds for bone tissue engineering","volume":"18","author":"Bitar","year":"2007","journal-title":"J Mater Sci Mater Med"},{"key":"2025092415012144800_szaf035-B31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s10544-010-9415-4","article-title":"Compressed collagen gel as the scaffold for skin engineering","volume":"12","author":"Hu","year":"2010","journal-title":"Biomed Microdevices"},{"key":"2025092415012144800_szaf035-B32","doi-asserted-by":"publisher","first-page":"8915","DOI":"10.1016\/j.biomaterials.2011.08.016","article-title":"Accelerated mineralization of dense collagen-nano bioactive glass hybrid gels increases scaffold stiffness and regulates osteoblastic function","volume":"32","author":"Marelli","year":"2011","journal-title":"Biomaterials"},{"key":"2025092415012144800_szaf035-B33","doi-asserted-by":"publisher","first-page":"100322","DOI":"10.1016\/j.mtbio.2022.100322","article-title":"Collagen fibril formation in vitro: from origin to opportunities","volume":"15","author":"Darvish","year":"2022","journal-title":"Mater Today Bio"},{"key":"2025092415012144800_szaf035-B34","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1016\/j.actbio.2013.08.038","article-title":"Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales","volume":"10","author":"Walters","year":"2014","journal-title":"Acta Biomater"},{"key":"2025092415012144800_szaf035-B35","doi-asserted-by":"publisher","first-page":"3422","DOI":"10.1073\/pnas.97.7.3422","article-title":"Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization","volume":"97","author":"Kalka","year":"2000","journal-title":"Proc Natl Acad Sci"},{"key":"2025092415012144800_szaf035-B36","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jcyt.2016.01.012","article-title":"Isolation and trans-differentiation of mesenchymal stromal cells into smooth muscle cells: Utility and applicability for Cell-Sheet engineering","volume":"18","author":"Shudo","year":"2016","journal-title":"Cytotherapy"},{"key":"2025092415012144800_szaf035-B37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF03085963","article-title":"Regulation and characteristics of vascular smooth muscle cell phenotypic diversity","volume":"15","author":"Rensen","year":"2007","journal-title":"Neth Heart J"},{"key":"2025092415012144800_szaf035-B38","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/jmri.1218","article-title":"Serial cine-magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats","volume":"14","author":"Nahrendorf","year":"2001","journal-title":"J Magn Reson Imaging"},{"key":"2025092415012144800_szaf035-B39","doi-asserted-by":"crossref","first-page":"9641527","DOI":"10.1155\/2018\/9641527","article-title":"Manganese-enhanced T1 mapping in the myocardium of normal and infarcted hearts","volume":"2018","author":"Spath","year":"2018","journal-title":"Contrast Media Mol Imaging"},{"key":"2025092415012144800_szaf035-B40","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1038\/nprot.2008.138","article-title":"Measurement of cardiac function using pressure\u2013volume conductance catheter technique in mice and rats","volume":"3","author":"Pacher","year":"2008","journal-title":"Nat Protoc"},{"key":"2025092415012144800_szaf035-B41","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/mt.2014.225","article-title":"Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart","volume":"23","author":"Kainuma","year":"2015","journal-title":"Mol Ther"},{"key":"2025092415012144800_szaf035-B42","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1158\/1078-0432.CCR-08-0212","article-title":"Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs","volume":"14","author":"Bhattacharya","year":"2008","journal-title":"Clin Cancer Res"},{"key":"2025092415012144800_szaf035-B43","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2025092415012144800_szaf035-B44","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2025092415012144800_szaf035-B45","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2025092415012144800_szaf035-B46","doi-asserted-by":"publisher","first-page":"W317","DOI":"10.1093\/nar\/gkab447","article-title":"KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis","volume":"49","author":"Bu","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2025092415012144800_szaf035-B47","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1161\/CIRCULATIONAHA.107.759480","article-title":"Comparison of different adult stem cell types for treatment of myocardial ischemia","volume":"118","author":"van der Bogt","year":"2008","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B48","doi-asserted-by":"publisher","first-page":"1164166","DOI":"10.3389\/fcell.2023.1164166","article-title":"The role of the ERK signaling pathway in promoting angiogenesis for treating ischemic diseases","volume":"11","author":"Song","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"2025092415012144800_szaf035-B49","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/cr.2008.326","article-title":"Ten dijke P. TGF-\u03b2 signaling in vascular biology and dysfunction","volume":"19","author":"Goumans","year":"2009","journal-title":"Cell Res"},{"key":"2025092415012144800_szaf035-B50","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.clbc.2020.01.007","article-title":"Prognostic and predictive impact of beta-2 adrenergic receptor expression in HER2-Positive breast cancer","volume":"20","author":"Caparica","year":"2020","journal-title":"Clin Breast Cancer"},{"key":"2025092415012144800_szaf035-B51","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1161\/01.CIR.0000033971.56802.C5","article-title":"Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs","volume":"106","author":"Emanueli","year":"2002","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B52","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/abbs\/gmz012","article-title":"The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation","volume":"51","author":"Yang","year":"2019","journal-title":"Acta Biochim Biophys Sin"},{"key":"2025092415012144800_szaf035-B53","doi-asserted-by":"publisher","first-page":"7468","DOI":"10.1074\/jbc.M110.179242","article-title":"FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress","volume":"286","author":"Sengupta","year":"2011","journal-title":"J Biol Chem"},{"key":"2025092415012144800_szaf035-B54","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/path.3000","article-title":"Anoikis: an emerging hallmark in health and diseases","volume":"226","author":"Taddei","year":"2012","journal-title":"J Pathol"},{"key":"2025092415012144800_szaf035-B55","doi-asserted-by":"publisher","first-page":"8251","DOI":"10.1038\/s41467-023-43900-0","article-title":"Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis","volume":"14","author":"Chaube","year":"2023","journal-title":"Nat Commun"},{"key":"2025092415012144800_szaf035-B56","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.107.157586","article-title":"CIB1 regulates endothelial cells and Ischemia-Induced pathological and adaptive angiogenesis","volume":"101","author":"Zayed","year":"2007","journal-title":"Circ Res"},{"key":"2025092415012144800_szaf035-B57","doi-asserted-by":"publisher","first-page":"e16979","DOI":"10.1371\/journal.pone.0016979","article-title":"MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. Capogrossi M, ed","volume":"6","author":"Sabatel","year":"2011","journal-title":"PLoS ONE"},{"key":"2025092415012144800_szaf035-B58","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/MOH.0000000000000580","article-title":"ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis","volume":"27","author":"Fern\u00e1ndez-Hernando","year":"2020","journal-title":"Curr Opin Hematol"},{"key":"2025092415012144800_szaf035-B59","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1165\/rcmb.2007-0274OC","article-title":"Apoptotic sphingolipid signaling by ceramides in lung endothelial cells","volume":"38","author":"Medler","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2025092415012144800_szaf035-B60","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.cellsig.2009.08.001","article-title":"Evidence for the involvement of FAM110C protein in cell spreading and migration","volume":"21","author":"Hauge","year":"2009","journal-title":"Cell Signal"},{"key":"2025092415012144800_szaf035-B61","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.stem.2010.11.016","article-title":"Tissue-Resident adult stem cell populations of rapidly Self-Renewing organs","volume":"7","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2025092415012144800_szaf035-B62","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.atherosclerosis.2019.07.022","article-title":"Allograft inflammatory factor-1 supports macrophage survival and efferocytosis and limits necrosis in atherosclerotic plaques","volume":"289","author":"Ega\u00f1a-Gorro\u00f1o","year":"2019","journal-title":"Atherosclerosis"},{"key":"2025092415012144800_szaf035-B63","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1002\/hep.24598","article-title":"Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a Central activator of transforming growth factor beta","volume":"54","author":"Bourd-Boittin","year":"2011","journal-title":"Hepatol Baltim Md"},{"key":"2025092415012144800_szaf035-B64","doi-asserted-by":"publisher","first-page":"105881","DOI":"10.1016\/j.biocel.2020.105881","article-title":"The therapeutic potential of galectin-3 inhibition in fibrotic disease","volume":"130","author":"Slack","year":"2021","journal-title":"Int J Biochem Cell Biol"},{"key":"2025092415012144800_szaf035-B65","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting cardiac fibrosis with engineered T cells","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature"},{"key":"2025092415012144800_szaf035-B66","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.jid.2016.02.021","article-title":"Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix","volume":"136","author":"Schiavinato","year":"2016","journal-title":"J Invest Dermatol"},{"key":"2025092415012144800_szaf035-B67","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.3390\/ijms23084358","article-title":"IGFBP-6: At the crossroads of immunity, tissue repair and fibrosis","volume":"23","author":"Liso","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025092415012144800_szaf035-B68","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1161\/CIRCULATIONAHA.105.588954","article-title":"In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery","volume":"113","author":"Cao","year":"2006","journal-title":"Circulation"},{"key":"2025092415012144800_szaf035-B69","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ Res"},{"key":"2025092415012144800_szaf035-B70","doi-asserted-by":"publisher","first-page":"141","DOI":"10.15171\/apb.2015.021","article-title":"The effect of hypoxia on mesenchymal stem cell biology","volume":"5","author":"Ejtehadifar","year":"2015","journal-title":"Adv Pharm Bull"},{"key":"2025092415012144800_szaf035-B71","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.3892\/mmr.2015.4691","article-title":"Hypoxia induces the proliferation of endothelial progenitor cells via upregulation of apelin\/APLNR\/MAPK signaling","volume":"13","author":"Zhang","year":"2016","journal-title":"Mol Med Rep"},{"key":"2025092415012144800_szaf035-B72","doi-asserted-by":"publisher","first-page":"H812","DOI":"10.1152\/ajpheart.00335.2017","article-title":"Guidelines for experimental models of myocardial ischemia and infarction","volume":"314","author":"Lindsey","year":"2018","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"2025092415012144800_szaf035-B73","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s10456-023-09870-z","article-title":"The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions","volume":"26","author":"Fan","year":"2023","journal-title":"Angiogenesis"},{"key":"2025092415012144800_szaf035-B74","doi-asserted-by":"publisher","first-page":"896782","DOI":"10.3389\/fcvm.2022.896782","article-title":"Regulation of endothelial progenitor cell functions in ischemic heart disease: New therapeutic targets for cardiac remodeling and repair","volume":"9","author":"Huang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"2025092415012144800_szaf035-B75","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/CIRCRESAHA.115.307516","article-title":"A Large-Scale investigation of Hypoxia-Preconditioned allogeneic mesenchymal stem cells for myocardial repair in nonhuman primates","volume":"118","author":"Hu","year":"2016","journal-title":"Circ Res"},{"key":"2025092415012144800_szaf035-B76","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/sj.mt.6300374","article-title":"Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance","volume":"16","author":"Cheng","year":"2008","journal-title":"Mol Ther"},{"key":"2025092415012144800_szaf035-B77","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jcis.2015.04.005","article-title":"Controlled delivery of stromal derived factor-1\u03b1 from poly Lactic-Co-Glycolic acid core\u2013shell particles to recruit mesenchymal stem cells for cardiac regeneration","volume":"451","author":"Zamani","year":"2015","journal-title":"J Colloid Interface Sci"},{"key":"2025092415012144800_szaf035-B78","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","article-title":"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization","volume":"85","author":"Asahara","year":"1999","journal-title":"Circ Res"},{"key":"2025092415012144800_szaf035-B79","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1016\/j.biomaterials.2013.08.017","article-title":"The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction","volume":"34","author":"Serpooshan","year":"2013","journal-title":"Biomaterials"},{"key":"2025092415012144800_szaf035-B80","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-065x.2001.1840113.x","article-title":"The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?","volume":"184","author":"Rolstad","year":"2001","journal-title":"Immunol Rev"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/14\/9\/szaf035\/64326877\/szaf035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/14\/9\/szaf035\/64326877\/szaf035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T19:01:40Z","timestamp":1758740500000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/doi\/10.1093\/stcltm\/szaf035\/8258801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":80,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,11]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szaf035","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"type":"print","value":"2157-6564"},{"type":"electronic","value":"2157-6580"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,9]]},"article-number":"szaf035"}}