{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:26:37Z","timestamp":1760747197371,"version":"build-2065373602"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases","award":["CXZX-202306"],"award-info":[{"award-number":["CXZX-202306"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Joint bone destruction in rheumatoid arthritis (RA) leads to poor prognosis, with current treatments mainly targeting inflammation and limited focus on bone damage. Mesenchymal stem cells (MSCs) offer anti-inflammatory and bone repair properties, but their clinical application is hindered by cellular heterogeneity. Induced pluripotent stem cell\u2013derived mesenchymal stem cells (iMSCs) present a promising alternative due to their lower heterogeneity and replicative senescence, although their potential in RA treatment remains underexplored.<\/jats:p>\n               <jats:p>Methods: iMSCs were injected intraarticularly in a collagen-induced arthritis (CIA) model. Treatment outcomes, including plantar swelling, joint score, histological and immunohistochemical staining, microCT imaging, and bone loss, were assessed. Single-cell RNA sequencing was employed to study iMSCs\u2019 effects on synovial macrophage subsets.<\/jats:p>\n               <jats:p>Results: In vivo, iMSCs significantly reduced systemic inflammation and joint bone damage. Analysis of macrophage subpopulations revealed that iMSCs shifted macrophages from a pro-inflammatory CD86hiIL1\u03b2hi cluster to an anti-inflammatory CD86hiIL1\u03b2lo cluster, leading to reduced inflammation and bone resorption.<\/jats:p>\n               <jats:p>Conclusions: iMSCs effectively alleviate inflammation and bone damage in CIA by modulating macrophage phenotypes, demonstrating potential for RA therapy.<\/jats:p>","DOI":"10.1093\/stcltm\/szaf045","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:05:57Z","timestamp":1760659557000},"source":"Crossref","is-referenced-by-count":0,"title":["iPSC-derived MSCs alleviate arthritis in collagen-induced arthritis mice by reducing synovial CD86h\n\u00a0iIL1\u03b2hi macrophage"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-4577","authenticated-orcid":false,"given":"Zewen","family":"Wu","sequence":"first","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital , Taiyuan 030032,","place":["China"]},{"name":"Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases , Taiyuan 030032,","place":["China"]},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic diseases) , Taiyuan 030032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhen","family":"Su","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital , Taiyuan 030032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital , Taiyuan 030032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinling","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanxi University of Chinese Medicine , Jinzhong 030619,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital , Taiyuan 030032,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanxi Medical University , Taiyuan 030001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LinXin","family":"Li","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji 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