{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:07:24Z","timestamp":1761955644622,"version":"build-2065373602"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Canada First Research Excellence Fund \u201cMedicine by Design\u201d Pivotal Experiment Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic compressive cervical spinal cord injury (cCSCI), a debilitating condition, lacks effective treatment options. Addressing this gap, our study introduces a novel rat model of cCSCI developed through spinal cord compression via synthetic polyether sheet implantation, closely mimicking human pathology. We evaluated the model\u2019s fidelity utilizing a comprehensive series of behavioral, electrophysiological, and histological assessments. Our research also explored the therapeutic potential of oligodendrogenic neural progenitor cells (oNPCs) derived from induced pluripotent stem cells. Transplanted oNPCs successfully integrated into the host spinal cord, differentiated into neurons, astrocytes, and oligodendrocytes, and demonstrated a remarkable capacity for enhancing neuroplasticity. Electrophysiological analyses revealed significant improvements in motor evoked potentials and a rectification of the excitability imbalance posttransplantation, indicating substantial recovery of motor circuits. Histological findings complemented these results, showing enhanced remyelination and a reduction in excitatory transmitter expression in the residual gray matter. Functionally, the transplantation of oNPCs led to marked improvements in grip strength, locomotor abilities, and sensory functions, surpassing those seen with standard treatments. This study not only provides a novel and reliable rat model of cCSCI for further research but also highlights the potential of oNPCs as a transformative approach for spinal cord injury therapy, suggesting their significant role in neural regeneration and repair.<\/jats:p>","DOI":"10.1093\/stcltm\/szaf047","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:52:23Z","timestamp":1758628343000},"source":"Crossref","is-referenced-by-count":0,"title":["Oligodendrogenic neural progenitors for treatment of chronic compressive cervical spinal cord injury"],"prefix":"10.1093","volume":"14","author":[{"given":"Zixiang","family":"Luo","sequence":"first","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]},{"name":"Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University , Changsha 410008, Hunan,","place":["China"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, ON M5S 3K3,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Lou","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, ON M5S 3K3,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Masoud","family":"Zavvarian","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, ON M5S 3K3,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sogolie","family":"Kouhzaei","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University , Changsha 410008, Hunan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-6364","authenticated-orcid":false,"given":"Michael G","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Division of Genetics and Development, Krembil Research Institute, University Health Network , Toronto, ON M5T 0S8,","place":["Canada"]},{"name":"Institute of Medical Science, University of Toronto , Toronto, ON M5S 3K3,","place":["Canada"]},{"name":"Department of Surgery and Spine Program, University of Toronto , Toronto, ON M5T 1P5,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2025103120023826100_szaf047-B1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41582-019-0303-0","article-title":"Degenerative cervical myelopathy\u2014update and future directions","volume":"16","author":"Badhiwala","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"2025103120023826100_szaf047-B2","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1136\/bmj.2.5373.1607","article-title":"Natural history and prognosis of cervical spondylosis","volume":"2","author":"Lees","year":"1963","journal-title":"Br Med 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