{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:44:47Z","timestamp":1767962687735,"version":"3.49.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Don Anderson GVHD fund and Crystal Carney Fund for Leukemia Research","award":["NIH\/NHLBI R01 HL153721"],"award-info":[{"award-number":["NIH\/NHLBI R01 HL153721"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Whole-body exposure to ionizing radiation can lead to cellular DNA damage to bone marrow (BM), causing lethal hematopoietic acute radiation syndrome (H-ARS). Extracellular vesicles (EVs) from human BM-derived mesenchymal stromal cells were primed with CRX-527 (CRX), a synthetic TLR4 agonist, characterized and tested as a radiomitigator therapy. Using a xenogeneic H-ARS mouse model, a single in vivo treatment with CRX-EVs administered 4 or 24\u2009hours after lethal irradiation significantly improved weight loss, clinical scores and prolonged survival compared to control treatments. Ex vivo generation of CRX-EV educated monocytes (CRX-EEMos) were also effective in a H-ARS model when administered 24\u2009hours after lethal irradiation. CRX-EVs or CRX-EEMos significantly promoted hematopoiesis in BM and potentially the spleen, leading to restoration of peripheral complete blood counts. CRX-EEMos showed increased gene expression of IL-6 and IL-10: enriched for PD-L1 but low for CD16 in CD14-expressing monocytes. Antisense inhibition of Let-7 microRNAs in CRX-EEMos suppressed IL-10 gene expression and protein secretion, implicating a novel role for Let-7 in radioprotection. CRX-EVs can effectively treat H-ARS by increasing the secretion of anti-inflammatory molecules while stimulating monocytes to promote hematopoiesis in BM. The potential for large-scale production of CRX-EVs as an \u201coff-the-shelf\u201d treatment for H-ARS makes them a potential medical countermeasure for radiological and nuclear threats.<\/jats:p>","DOI":"10.1093\/stcltm\/szaf068","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T12:54:05Z","timestamp":1763470445000},"source":"Crossref","is-referenced-by-count":0,"title":["Extracellular vesicles from mesenchymal stromal cells primed with synthetic toll-like receptor 4 agonists treat hematopoietic acute radiation syndrome"],"prefix":"10.1093","volume":"15","author":[{"given":"John A","family":"Kink","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]},{"name":"University of Wisconsin Carbone Cancer Center , Madison, WI 53705,","place":["United States"]},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek M","family":"Krismer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S","family":"Thickens","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1877-8975","authenticated-orcid":false,"given":"Raghavan","family":"Chinnadurai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Mercer University School of Medicine , Savannah, GA 31404,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"Chacko","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Graham","sequence":"additional","affiliation":[{"name":"The Comparative Pathology Laboratory, Research Animal Resource Center, University of Wisconsin , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiman","family":"Hematti","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Medical College of Wisconsin , Milwaukee, WI 53226,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-6731","authenticated-orcid":false,"given":"Christian M","family":"Capitini","sequence":"additional","affiliation":[{"name":"University of Wisconsin Carbone Cancer Center , Madison, WI 53705,","place":["United States"]},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2026010905594714700_szaf068-B1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/s0140-6736","article-title":"Nuclear disasters and health: lessons learned, challenges, and proposals","volume":"386","author":"Ohtsuru","year":"2015","journal-title":"Lancet (London, England)"},{"key":"2026010905594714700_szaf068-B2","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1667\/rr14810.1","article-title":"Cellular therapies for treatment of radiation injury: report from a NIH\/NIAID and IRSN workshop","volume":"188","author":"DiCarlo","year":"2017","journal-title":"Radiat Res."},{"key":"2026010905594714700_szaf068-B3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/rpd\/ncw233","article-title":"Protecting public health in nuclear emergencies-the need to broaden the process","volume":"171","author":"Carr","year":"2016","journal-title":"Radiat Prot Dosimetry."},{"key":"2026010905594714700_szaf068-B4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/hp.0000000000000747","article-title":"How prepared are the public and responders for nuclear terrorism?","volume":"114","author":"Buddemeier","year":"2018","journal-title":"Health Phys."},{"key":"2026010905594714700_szaf068-B5","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1093\/pubmed\/fdz102","article-title":"Nuclear war and public health: preparedness, protection and the case for prevention","volume":"42","author":"Boulton","year":"2020","journal-title":"J Public Health (Oxf)"},{"key":"2026010905594714700_szaf068-B6","doi-asserted-by":"publisher","first-page":"966","DOI":"10.3357\/amhp.5370.2019","article-title":"Challenges in clinical management of radiation-induced illnesses during exploration spaceflight","volume":"90","author":"Blue","year":"2019","journal-title":"Aerosp Med Hum Perform."},{"key":"2026010905594714700_szaf068-B7","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1088\/1361-6498\/ac2678","article-title":"Review of engagement activities to promote awareness of radiation and its associated risk amongst the Japanese public before and after the Fukushima Daiichi nuclear power plant accident","volume":"41","author":"Sakoda","year":"2021","journal-title":"J Radiol Prot"},{"key":"2026010905594714700_szaf068-B8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1093\/rpd\/ncy144","article-title":"Coordination of management of the acute radiation syndrome","volume":"182","author":"Stenke","year":"2018","journal-title":"Radiat Prot Dosimetry."},{"key":"2026010905594714700_szaf068-B9","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1080\/09553002.2021.1969054","article-title":"Radiation countermeasures for hematopoietic acute radiation syndrome: growth factors, cytokines and beyond","volume":"97","author":"Singh","year":"2021","journal-title":"Int J Radiat Biol."},{"key":"2026010905594714700_szaf068-B10","doi-asserted-by":"publisher","first-page":"ii54","DOI":"10.1093\/jrr\/rry004","article-title":"Medical management of acute radiation syndrome and associated infections in a high-casualty incident","volume":"59","author":"Dainiak","year":"2018","journal-title":"J Radiat Res."},{"key":"2026010905594714700_szaf068-B11","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.rpor.2011.05.001","article-title":"Medical management of the acute radiation syndrome","volume":"16","author":"L\u00f3pez","year":"2011","journal-title":"Rep Pract Oncol Radiother."},{"key":"2026010905594714700_szaf068-B12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cyto.2014.08.003","article-title":"Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review","volume":"71","author":"Singh","year":"2015","journal-title":"Cytokine."},{"key":"2026010905594714700_szaf068-B13","doi-asserted-by":"publisher","first-page":"741485","DOI":"10.3389\/fphar.2021.634477","article-title":"Polypharmacy to mitigate acute and delayed radiation syndromes","volume":"12","author":"Gasperetti","year":"2021","journal-title":"Front Pharmacol."},{"key":"2026010905594714700_szaf068-B14","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1080\/17460441.2019.1604674","article-title":"Drug discovery strategies for acute radiation syndrome","volume":"14","author":"Singh","year":"2019","journal-title":"Expert Opin Drug Discov."},{"key":"2026010905594714700_szaf068-B15","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J Proteomics."},{"key":"2026010905594714700_szaf068-B16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3390\/ijms21030727","article-title":"Current knowledge and future perspectives on mesenchymal stem Cell-Derived exosomes as a new therapeutic agent","volume":"21","author":"Joo","year":"2020","journal-title":"Int J Mol Sci."},{"key":"2026010905594714700_szaf068-B17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1080\/14653240903193806","article-title":"Mesenchymal stem cells in hematopoietic stem cell transplantation","volume":"11","author":"Battiwalla","year":"2009","journal-title":"Cytotherapy."},{"key":"2026010905594714700_szaf068-B18","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jcyt.2015.11.008","article-title":"International society for cellular therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials","volume":"18","author":"Galipeau","year":"2016","journal-title":"Cytotherapy."},{"key":"2026010905594714700_szaf068-B19","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1016\/j.bbmt.2019.07.026","article-title":"Macrophages educated with exosomes from primed mesenchymal stem cells treat acute radiation syndrome by promoting hematopoietic recovery","volume":"25","author":"Kink","year":"2019","journal-title":"Biol Blood Marrow Transplant."},{"key":"2026010905594714700_szaf068-B20","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s13287-021-02491-7","article-title":"Exosomes from primed MSCs can educate monocytes as a cellular therapy for hematopoietic acute radiation syndrome","volume":"12","author":"Forsberg","year":"2021","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13287-024-03688-2","article-title":"Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome","volume":"15","author":"Kink","year":"2024","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B22","doi-asserted-by":"publisher","first-page":"4440","DOI":"10.1074\/jbc.M310760200","article-title":"Structure-activity relationship of synthetic toll-like receptor 4 agonists","volume":"279","author":"St\u00f6ver","year":"2004","journal-title":"J Biol Chem."},{"key":"2026010905594714700_szaf068-B23","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1093\/stmcls\/sxae028","article-title":"Modulating the mesenchymal stromal cell microenvironment alters exosome RNA content and ligament healing capacity","volume":"42","author":"Chamberlain","year":"2024","journal-title":"Stem Cells (Dayton, Ohio)"},{"key":"2026010905594714700_szaf068-B24","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.exphem.2009.09.004","article-title":"Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages","volume":"37","author":"Kim","year":"2009","journal-title":"Exp Hematol."},{"key":"2026010905594714700_szaf068-B25","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"30","author":"Thery","year":"2006","journal-title":"CP Cell Biol"},{"key":"2026010905594714700_szaf068-B26","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230","article-title":"An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin","volume":"88","author":"Cooke","year":"1996","journal-title":"Blood"},{"key":"2026010905594714700_szaf068-B27","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1177\/0192623310396907","article-title":"Best practices for evaluation of bone marrow in nonclinical toxicity studies","volume":"39","author":"Reagan","year":"2011","journal-title":"Toxicol Pathol."},{"key":"2026010905594714700_szaf068-B28","doi-asserted-by":"publisher","first-page":"78","DOI":"10.30802\/aalas-cm-21-000082","article-title":"Effect of antimicrobial prophylaxis on Corynebacterium bovis infection and the skin microbiome of immunodeficient mice","volume":"72","author":"Manuel","year":"2022","journal-title":"Comp Med."},{"key":"2026010905594714700_szaf068-B29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s40778-020-00176-0","article-title":"Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome","volume":"6","author":"Chinnadurai","year":"2020","journal-title":"Curr Stem Cell Rep."},{"key":"2026010905594714700_szaf068-B30","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1017\/s1462399411001943","article-title":"Inflammation and wound healing: the role of the macrophage","volume":"13","author":"Koh","year":"2011","journal-title":"Expert Rev Mol Med."},{"key":"2026010905594714700_szaf068-B31","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/wrr.12444","article-title":"Macrophages: a review of their role in wound healing and their therapeutic use","volume":"24","author":"Snyder","year":"2016","journal-title":"Wound Repair Regen."},{"key":"2026010905594714700_szaf068-B32","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.bbmt.2017.02.018","article-title":"Human mesenchymal stem cell-educated macrophages are a distinct high IL-6-producing subset that confer protection in graft-versus-host-disease and radiation injury models","volume":"23","author":"Bouchlaka","year":"2017","journal-title":"Biol Blood Marrow Transplant."},{"key":"2026010905594714700_szaf068-B33","doi-asserted-by":"publisher","first-page":"676356","DOI":"10.3389\/fcell.2021.676356","article-title":"Priming with Toll-Like receptor 3 agonist poly(I: C) enhances content of innate immune defense proteins but not microRNAs in human mesenchymal stem cell-derived extracellular vesicles","volume":"9","author":"Pierce","year":"2021","journal-title":"Front Cell Dev Biol."},{"key":"2026010905594714700_szaf068-B34","first-page":"267","article-title":"Pathogenic effects of endotoxin","volume":"3","author":"Zivot","year":"1995","journal-title":"New Horiz"},{"key":"2026010905594714700_szaf068-B35","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.coi.2020.08.008","article-title":"New horizons in adjuvants for vaccine development","volume":"65","author":"Reed","year":"2020","journal-title":"Curr Opin Immunol."},{"key":"2026010905594714700_szaf068-B36","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/eji.200939992","article-title":"CD14-independent responses induced by a synthetic lipid a mimetic","volume":"40","author":"Legat","year":"2010","journal-title":"Eur J Immunol."},{"key":"2026010905594714700_szaf068-B37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13287-019-1215-z","article-title":"Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes","volume":"10","author":"Ragni","year":"2019","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B38","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1146\/annurev.cellbio.23.090506.123337","article-title":"Hyaluronan in tissue injury and repair","volume":"23","author":"Jiang","year":"2007","journal-title":"Annu Rev Cell Dev Biol."},{"key":"2026010905594714700_szaf068-B39","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s13287-021-02329-2","article-title":"Role of CD44 in increasing the potency of mesenchymal stem cell extracellular vesicles by hyaluronic acid in severe pneumonia","volume":"12","author":"Zhou","year":"2021","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B40","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1126\/science.aai8132","article-title":"Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells","volume":"356","author":"Bosurgi","year":"2017","journal-title":"Science (New York, N.Y.)"},{"key":"2026010905594714700_szaf068-B41","doi-asserted-by":"publisher","first-page":"1434872","DOI":"10.1155\/2017\/1434872","article-title":"Chemokines (CCL3, CCL4, and CCL5) inhibit ATP-induced release of IL-1beta by monocytic cells","volume":"2017","author":"Amati","year":"2017","journal-title":"Mediators Inflamm."},{"key":"2026010905594714700_szaf068-B42","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s41232-019-0101-5","article-title":"The role of interleukin-1 in general pathology","volume":"39","author":"Kaneko","year":"2019","journal-title":"Inflamm Regen."},{"key":"2026010905594714700_szaf068-B43","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1254\/jphs.crj06010x","article-title":"Systemic inflammatory response syndrome (SIRS): molecular pathophysiology and gene therapy","volume":"101","author":"Matsuda","year":"2006","journal-title":"J Pharmacol Sci."},{"key":"2026010905594714700_szaf068-B44","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1667\/rr3031.1","article-title":"Cytokines in radiobiological responses: a review","volume":"178","author":"Schaue","year":"2012","journal-title":"Radiat Res."},{"key":"2026010905594714700_szaf068-B45","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nm.2106","article-title":"Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection","volume":"16","author":"Said","year":"2010","journal-title":"Nat Med."},{"key":"2026010905594714700_szaf068-B46","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"Roush","year":"2008","journal-title":"Trends Cell Biol."},{"key":"2026010905594714700_szaf068-B47","doi-asserted-by":"publisher","first-page":"359","DOI":"10.4049\/jimmunol.2200467","article-title":"MicroRNAs in macrophages: regulators of activation and function","volume":"210","author":"Sprenkle","year":"2023","journal-title":"J Immunol"},{"key":"2026010905594714700_szaf068-B48","doi-asserted-by":"publisher","first-page":"6542","DOI":"10.4049\/jimmunol.1202496","article-title":"MicroRNA let-7c regulates macrophage polarization","volume":"190","author":"Banerjee","year":"2013","journal-title":"J Immunol"},{"key":"2026010905594714700_szaf068-B49","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.4049\/jimmunol.1502599","article-title":"TLR10 is a negative regulator of both MyD88-dependent and -independent TLR signaling","volume":"196","author":"Jiang","year":"2016","journal-title":"J Immunol"},{"key":"2026010905594714700_szaf068-B50","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1038\/emboj.2011.94","article-title":"Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family","volume":"30","author":"Schulte","year":"2011","journal-title":"EMBO J."},{"key":"2026010905594714700_szaf068-B51","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1667\/rr1931.1","article-title":"Links between innate immunity and normal tissue radiobiology","volume":"173","author":"Schaue","year":"2010","journal-title":"Radiat Res."},{"key":"2026010905594714700_szaf068-B52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1093\/procel\/pwad044","article-title":"Radiation injury and gut microbiota-based treatment","volume":"15","author":"Wang","year":"2024","journal-title":"Protein Cell."},{"key":"2026010905594714700_szaf068-B53","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40164-023-00410-5","article-title":"The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury","volume":"12","author":"Yi","year":"2023","journal-title":"Exp Hematol Oncol."},{"key":"2026010905594714700_szaf068-B54","doi-asserted-by":"publisher","first-page":"e21615","DOI":"10.1016\/j.heliyon.2023.e21615","article-title":"The potential role of miRNA in regulating macrophage polarization","volume":"9","author":"Khayati","year":"2023","journal-title":"Heliyon."},{"key":"2026010905594714700_szaf068-B55","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s13287-024-04005-7","article-title":"Different storage and freezing protocols for extracellular vesicles: a systematic review","volume":"15","author":"Ahmadian","year":"2024","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B56","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.3390\/cells10061320","article-title":"MSC manufacturing for academic clinical trials: from a clinical-grade to a full GMP-compliant process","volume":"10","author":"Lechanteur","year":"2021","journal-title":"Cells."},{"key":"2026010905594714700_szaf068-B57","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13287-021-02190-3","article-title":"Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell","volume":"12","author":"Gobin","year":"2021","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B58","doi-asserted-by":"publisher","first-page":"e128","DOI":"10.1002\/cpsc.128","article-title":"Scaled isolation of mesenchymal stem\/stromal cell-derived extracellular vesicles","volume":"55","author":"B\u00f6rger","year":"2020","journal-title":"Curr Protoc Stem Cell Biol."},{"key":"2026010905594714700_szaf068-B59","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13287-017-0559-5","article-title":"The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response","volume":"8","author":"Han","year":"2017","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B60","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1111\/ajt.15819","article-title":"Xenogeneic transplantation of human WJ-MSCs rescues mice from acute radiation syndrome via Nrf-2-dependent regeneration of damaged tissues","volume":"20","author":"Bandekar","year":"2020","journal-title":"Am J Transplant."},{"key":"2026010905594714700_szaf068-B61","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/jcsm.12342","article-title":"Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells","volume":"9","author":"Pinzur","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle."},{"key":"2026010905594714700_szaf068-B62","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s13287-020-01887-1","article-title":"Extracellular vesicles derived from mesenchymal stromal cells mitigate intestinal toxicity in a mouse model of acute radiation syndrome","volume":"11","author":"Accarie","year":"2020","journal-title":"Stem Cell Res Ther."},{"key":"2026010905594714700_szaf068-B63","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1021\/acs.molpharmaceut.4c00298","article-title":"Investigating the in vivo biodistribution of extracellular vesicles isolated from various human cell sources using positron emission tomography","volume":"21","author":"Rosenkrans","year":"2024","journal-title":"Mol Pharm."}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/15\/1\/szaf068\/66321286\/szaf068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/15\/1\/szaf068\/66321286\/szaf068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:59:52Z","timestamp":1767956392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/doi\/10.1093\/stcltm\/szaf068\/8417862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szaf068","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]},"article-number":"szaf068"}}