{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:05:39Z","timestamp":1771218339449,"version":"3.50.1"},"reference-count":147,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Royan Institute, Tehran, Iran"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The conserved, pluripotency-associated miR-302\/367 cluster coordinates cell fate and aging via epigenetic, cell cycle, and signaling regulation. Highly expressed in pluripotent stem cells and silenced during differentiation, it promotes efficient somatic cell reprogramming by suppressing senescence mediators (eg, p16INK4a, p21) and replacing oncogenes such as c-Myc to minimize tumorigenic risks. Beyond pluripotency, the miR-302\/367 cluster reduces oxidative stress, mitochondrial dysfunction, and fibrosis, indicating therapeutic potential in age-associated conditions such as neurodegenerative, ocular, and fibrotic diseases. This review summarizes the dual ability of miR-302\/367 cluster in promoting cell state transitions and transiently resetting cellular aging to enable healthspan extension. We critically discuss the pivotal role of miR-302\/367 cluster in pluripotency and reprogramming while countering aging hallmarks. Finally, we explore how combining single-miRNA therapeutics with clinically viable delivery systems (lipid nanoparticles and extracellular vesicles) can link cellular reprogramming with targeted rejuvenation therapies.<\/jats:p>","DOI":"10.1093\/stcltm\/szaf072","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:50:12Z","timestamp":1770209412000},"source":"Crossref","is-referenced-by-count":0,"title":["The harmonies played by miR-302\/367 cluster in pluripotency, reprogramming, and rejuvenation"],"prefix":"10.1093","volume":"15","author":[{"given":"Melika","family":"Zamanian","sequence":"first","affiliation":[{"name":"Department of Applied Cell Sciences, Faculty of Basic Sciences and Advanced Medical Technologies, Royan Institute, ACECR , Tehran 1665659911,","place":["Iran"]},{"name":"Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR , Tehran 1665659911,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2935-983X","authenticated-orcid":false,"given":"Sharif","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR , Tehran 1665659911,","place":["Iran"]},{"name":"Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture , Tehran 1461968151,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-3687","authenticated-orcid":false,"given":"Hossein","family":"Baharvand","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR , Tehran 1665659911,","place":["Iran"]},{"name":"Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture , Tehran 1461968151,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"2026021523224546800_szaf072-B1","doi-asserted-by":"crossref","first-page":"e0267291","DOI":"10.1371\/journal.pone.0267291","article-title":"Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: a study based on TCGA database","volume":"17","author":"Moradi","year":"2022","journal-title":"PLoS One"},{"key":"2026021523224546800_szaf072-B2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00439-019-02046-0","article-title":"MicroRNAs as modulators of longevity and the aging 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