{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:08:58Z","timestamp":1778202538207,"version":"3.51.4"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["20210302123315"],"award-info":[{"award-number":["20210302123315"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["202303021221128"],"award-info":[{"award-number":["202303021221128"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disease, is characterized by disrupted intestinal barrier integrity and unresolved endoplasmic reticulum (ER) stress, which drives epithelial apoptosis and disease progression. While mesenchymal stem cells (MSCs), particularly human umbilical cord\u2013derived MSCs (hUC-MSCs), have shown therapeutic potential in UC, their mechanisms in modulating ER stress remain unclear. This study aimed to investigate the role of hUC-MSCs in alleviating ER stress\u2013induced epithelial damage and elucidate the underlying molecular pathways in a murine colitis model and in vitro systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraperitoneal administration of hUC-MSCs significantly attenuated dextran sulfate sodium (DSS)-induced colitis in mice. Histological analysis revealed restored crypt architecture and reduced epithelial apoptosis. Transcriptomic profiling demonstrated that hUC-MSCs reduced differentially expressed genes in inflammatory bowel disease\u2013related and ER stress response pathways in colon tissues. Mechanistically, hUC-MSCs activated the IRE1\/XBP1 axis, increasing Xbp1 splicing and suppressing pro-apoptotic Bcl2l11 expression. In vitro, hUC-MSC-conditioned medium protected colon epithelial cells from TNF-\u03b1-induced apoptosis via IRE1\/XBP1 activation, an effect abolished by the IRE1 inhibitor 4\u03bc8C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that hUC-MSCs alleviate UC by mitigating ER stress through IRE1-mediated Xbp1 splicing, thereby reducing epithelial apoptosis and promoting mucosal repair. This study provides a mechanistic foundation for MSC-based therapies targeting ER stress in inflammatory bowel diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stcltm\/szaf075","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:44:53Z","timestamp":1767098693000},"source":"Crossref","is-referenced-by-count":1,"title":["Human umbilical cord mesenchymal stem cells alleviate colon epithelial apoptosis in ulcerative colitis by activating inositol-requiring enzyme 1\/X-box binding protein 1 signaling"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9357-7928","authenticated-orcid":false,"given":"Taoran","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University , Taiyuan 030001,","place":["China"]},{"name":"Academy of Medical Sciences, Shanxi Medical University , Taiyuan 030001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyi","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University , Taiyuan 030001,","place":["China"]},{"name":"Academy of Medical Sciences, Shanxi Medical University , Taiyuan 030001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University , Taiyuan 030001,","place":["China"]},{"name":"Academy of Medical Sciences, Shanxi Medical University , Taiyuan 030001,","place":["China"]},{"name":"School of Public Health, Shanxi Medical University , Taiyuan 030001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Key Laboratory of Classical Prescription Strengthening Yang, Shanxi Hospital of Integrated Traditional and Western Medicine , Taiyuan 030001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoni","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanxi Hospital of Integrated Traditional and Western Medicine , Taiyuan 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