{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:07:07Z","timestamp":1771218427523,"version":"3.50.1"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260555"],"award-info":[{"award-number":["82260555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Innovation and Development Project of Lanzhou University","award":["lzuyxcx-2022-177"],"award-info":[{"award-number":["lzuyxcx-2022-177"]}]},{"name":"Major Science and Technology Projects of Gansu Province","award":["22ZD6FA021-4"],"award-info":[{"award-number":["22ZD6FA021-4"]}]},{"name":"Joint Research Fund General Projects of Gansu Province","award":["23JRRA1508"],"award-info":[{"award-number":["23JRRA1508"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis comprehensively evaluates the therapeutic efficacy and mechanisms of mesenchymal stem cells (MSCs) and their exosomes in rodent models of hepatic ischemia-reperfusion injury (HIRI), providing preclinical support for future clinical translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In accordance with the PRISMA guidelines, we systematically searched PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov for studies published from inception to January 13, 2025, and identified 64 eligible studies. Risk of bias was evaluated using the SYRCLE tool, and Review Manager 5.4.1 was employed for meta-analysis, calculating SMD and 95%CI. Primary outcomes included liver function (ALT\/AST), histopathological scores (Suzuki\u2019s score, necrotic area ratio), inflammatory cytokines (TNF-\u03b1), and apoptosis markers (c-caspase 3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MSCs and their exosomes significantly ameliorated HIRI. In the 60-minute ischemia group, ALT (SMD\u2009=\u20093.49, P &amp;lt; .00001) and AST (SMD\u2009=\u20093.86, P &amp;lt; .00001) decreased, along with lower Suzuki scores (SMD\u2009=\u20093.12), necrotic area ratios (SMD\u2009=\u20093.56), and TNF-\u03b1 levels (SMD\u2009=\u20092.83). In the 90-minute group, ALT (SMD\u2009=\u20094.09, P &amp;lt; .00001) and AST (SMD\u2009=\u20093.78, P &amp;lt; .00001) were also reduced. Mechanistically, MSCs exert therapeutic effects through antioxidative, anti-inflammatory, anti-apoptotic, and pro-regenerative pathways. Considerable heterogeneity (I2 = 52\u201386%) was observed, likely due to variations in dosage (1\u2009\u00d7\u2009105-1\u2009\u00d7\u2009109 cells), administration routes (intravenous\/portal vein), and reperfusion durations (3\u201324\u2009hours). Genetic modifications (e.g., HO-1 overexpression) further enhanced therapeutic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MSCs and their exosomes mitigate HIRI through multi-target mechanisms but requires standardized protocols. Future studies should prioritize large-animal validation and translational research to facilitate precision clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stcltm\/szaf078","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:31:30Z","timestamp":1768912290000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of MSCs and their exosomes in hepatic Ischaemia-Reperfusion injury: a systematic review and meta-analysis of rodent studies"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-766X","authenticated-orcid":false,"given":"Yanxi","family":"Mu","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ren","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]},{"name":"Department of General Surgery, Biotherapy, Lanzhou University Second Hospital , Lanzhou, 730000,","place":["China"]},{"name":"Gansu Province Precision Diagnosis and Treatment Engineering Research Center of Hepatobiliary Pancreatic Diseases, Gansu Province Key Laboratory of Environmental Oncology , Lanzhou, 730000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wence","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou, 730000,","place":["China"]},{"name":"Department of General Surgery, Biotherapy, Lanzhou University Second Hospital , Lanzhou, 730000,","place":["China"]},{"name":"Gansu Province Precision Diagnosis and Treatment Engineering Research Center of Hepatobiliary Pancreatic Diseases, Gansu Province Key Laboratory of Environmental Oncology , Lanzhou, 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