{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:06:59Z","timestamp":1771218419978,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"GID Bio Company at the UPMC Health System"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pelvic radiotherapy can lead to loss of bladder compliance, detrusor overactivity, and superficial vascular proliferation. Animal studies have demonstrated a reduction in radiation-induced inflammation and fibrosis following administration of mesenchymal stem cell products. We performed a first-in-human pilot study to assess the safety and feasibility of intravesical adipose stromal vascular fraction injection in an 82-year-old man with a history of brachytherapy for prostate cancer. Following FDA and IRB approval, subcutaneous adipose tissue harvested under local anesthesia was immediately processed using the SVF-2 device (GID Bio). The cell product, consisting of 4.58 \u00d7 107 stromal vascular fraction cells resuspended in 20 cc\/s of lactated ringers, was injected into the bladder wall using a flexible cystoscope. Urinary symptoms, urologic flow parameters, repeat cystoscopy with bladder biopsy, and MRI were employed during the 16-month follow-up period. There were no postprocedural complications. The patient reported expected symptoms of self-limited dysuria, hematuria, and flank bruising in the 2 weeks following the procedure. Urinary symptoms and flow parameters remained stable for 6\u2009months but progressed slightly at 15\u2009months. A repeat cystoscopy with biopsy showed stabilization of disease without concern for secondary malignancy. The patient\u2019s 12-month postprocedural MRI and 15-month urodynamics study were unchanged from prior. This study demonstrates the safety and feasibility of adipose harvest under local anesthesia, followed by point-of-care isolation and administration of an adipose-derived cell product via cystoscopic-guided intravesical injection. This pilot is foundational for further clinical studies to elucidate effective dosing and patient selection in the treatment of bladder fibrosis with cell therapy.<\/jats:p>","DOI":"10.1093\/stcltm\/szag002","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:39:03Z","timestamp":1768394343000},"source":"Crossref","is-referenced-by-count":0,"title":["Adipose-derived stromal vascular fraction injection for radiation-induced bladder fibrosis: a first-in-human pilot study"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1792","authenticated-orcid":false,"given":"Roger","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Urology, University of Pittsburgh Medical Center , Pittsburgh, PA 15213,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerone","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asim","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213,","place":["United States"]},{"name":"The McGowan Institute of Regenerative Medicine, University of Pittsburgh , Pittsburgh, PA 15213,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Peter","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213,","place":["United States"]},{"name":"The McGowan Institute of Regenerative Medicine, University of Pittsburgh , Pittsburgh, PA 15213,","place":["United States"]},{"name":"Department of Bioengineering, University of Pittsburgh , Pittsburgh, PA 15213,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Rusilko","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Pittsburgh Medical Center , Pittsburgh, PA 15213,","place":["United States"]},{"name":"Department of Plastic Surgery, University of Pittsburgh Medical Center , Pittsburgh, PA 15213,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"2026021523265670300_szag002-B1","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.eururo.2018.12.003","article-title":"Pelvic complications after prostate cancer radiation therapy and their management: an international collaborative narrative review","volume":"75","author":"Matta","year":"2019","journal-title":"Eur 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