{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:15:39Z","timestamp":1777626939288,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The University of Jordan\/Deanship of Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Knee osteoarthritis (KOA) is a progressive degenerative joint disease with limited treatment options that effectively modify disease progression. This study evaluates the safety and efficacy of allogeneic adipose-derived mesenchymal stromal cells (ADMSCs) injected under ultrasound guidance in patients with symptomatic stage III KOA. In this single-site, randomized, double-blind, placebo-controlled trial, patients were assigned to receive either 2 doses of allogeneic expanded ADMSCs, administered 2 weeks apart (Arm A, mean total dose: 69.58\u2009\u00d7\u2009106 ADMSCs), or 2 equal-volume normal saline injections (Arm B). Blinding was maintained for 12 months, after which follow-up of Arm A continued to 60 months. Treatment efficacy was assessed using normalized Knee Injury and Osteoarthritis Outcome Score and Western Ontario and McMaster Universities Osteoarthritis Index at 6, 12, 24, 36, 48, and 60 months, while magnetic resonance imaging (MRI) evaluations were performed at baseline and 12 months. A total of 29 subjects (21 in Arm A, 8 in Arm B) completed the study. Adverse events in Arm A were mild and transient, including localized pain and swelling. Patients in Arm A demonstrated significant improvements in clinical scores compared to baseline, with highly significant differences at 6, 12, 24, and 36 months (P\u2009&amp;lt;\u2009.0001). MRI assessments at 12 months revealed structural improvement (P\u2009&amp;lt;\u2009.02). However, clinical improvements declined steadily after 36 months, with scores nearing baseline at 60 months. These findings suggest that allogeneic ADMSC therapy is safe and provides sustained clinical and structural benefits for up to 3 years. Larger trials are needed to optimize dosing and assess long-term efficacy.<\/jats:p>","DOI":"10.1093\/stcltm\/szag018","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:33:43Z","timestamp":1770726823000},"source":"Crossref","is-referenced-by-count":0,"title":["Intra-articular allogeneic adipose-derived mesenchymal stromal cell injections for stage III knee osteoarthritis: a double-blind placebo-controlled trial with 60-month follow-up"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-8783","authenticated-orcid":false,"given":"Hanan","family":"Jafar","sequence":"first","affiliation":[{"name":"Cell Therapy Center (CTC), The University of Jordan , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Samara","sequence":"additional","affiliation":[{"name":"Department of Radiology & Nuclear Medicine, School of Medicine, The University of Jordan , Amman 11942,","place":["Jordan"]},{"name":"Department of Radiology, Jordan University Hospital , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Shahin","sequence":"additional","affiliation":[{"name":"Cell Therapy Center (CTC), The University of Jordan , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadwa","family":"Daoud","sequence":"additional","affiliation":[{"name":"Cell Therapy Center (CTC), The University of Jordan , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Al-Hattab","sequence":"additional","affiliation":[{"name":"Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology , Thuwal 23955-6900,","place":["Saudi Arabia"]},{"name":"KAUST Center of Excellence for Smart Health (KCSH), King Abdullah University of Science and Technology , Thuwal 23955-6900,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aseel","family":"Samara","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Jordan , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Al Lawama","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jordan University Hospital , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Department of Special Surgery, School of Medicine, The University of Jordan , Amman 11942,","place":["Jordan"]},{"name":"Department of Orthopedic Surgery, Jordan University Hospital , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Qubbaj","sequence":"additional","affiliation":[{"name":"Cell Therapy Center (CTC), The University of Jordan , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bareqa","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of General Surgery, School of Medicine, The University of Jordan , Amman 11942,","place":["Jordan"]},{"name":"Department of General Surgery, Plastic & Reconstructive, Jordan University Hospital , Amman 11942,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-948X","authenticated-orcid":false,"given":"Abdalla","family":"Awidi","sequence":"additional","affiliation":[{"name":"Cell Therapy Center (CTC), The University of Jordan , Amman 11942,","place":["Jordan"]},{"name":"Department of Internal Medicine, Hematology-Oncology, School of Medicine, The University of Jordan , Amman 11942,","place":["Jordan"]},{"name":"Department of Hematology-Oncology, Jordan University Hospital , Amman 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adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial","volume":"14","author":"Sadri","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"2026042820453217500_szag018-B4","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.3390\/biomedicines11071781","article-title":"Adipose-derived mesenchymal stromal cells: a tool for bone and cartilage repair","volume":"11","author":"Romano","year":"2023","journal-title":"Biomedicines"},{"key":"2026042820453217500_szag018-B5","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1302\/0301-620X.85B5.13587","article-title":"Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads","volume":"85-B","author":"Dragoo","year":"2003","journal-title":"J Bone Jt Surg Br"},{"key":"2026042820453217500_szag018-B6","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.14336\/AD.2019.1104","article-title":"Chondroprotective effects of combination therapy of acupotomy and human adipose mesenchymal stem cells in knee osteoarthritis rabbits via the gsk3\u03b2-cyclin D1-CDK4\/CDK6 signaling pathway","volume":"11","author":"An","year":"2020","journal-title":"Aging Dis"},{"key":"2026042820453217500_szag018-B7","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/stem.1634","article-title":"Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial","volume":"32","author":"Jo","year":"2014","journal-title":"Stem Cells"},{"key":"2026042820453217500_szag018-B8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.arthro.2012.11.017","article-title":"Mesenchymal stem cell injections improve symptoms of knee osteoarthritis","volume":"29","author":"Koh","year":"2013","journal-title":"Arthroscopy"},{"key":"2026042820453217500_szag018-B9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13287-025-04252-2","article-title":"Efficacy and 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