{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:08:42Z","timestamp":1781089722897,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Research Program of Henan Province","award":["232102311073"],"award-info":[{"award-number":["232102311073"]}]},{"name":"Science and Technology Research Program of Henan Province","award":["232102310175"],"award-info":[{"award-number":["232102310175"]}]},{"name":"Science and Technology Research Program of Henan Province grants","award":["232102311040"],"award-info":[{"award-number":["232102311040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Myelodysplastic syndromes (MDS), an age-related hematological malignancy, involve dysfunctional bone marrow mesenchymal stromal cells (BM-MSCs). Our study reveals that BM-MSCs from young refractory anemia with excess of blasts-1 (RAEB-1)\/MDS patients exhibit impaired proliferation, altered immunophenotype, and reduced immunosuppressive capacity compared to healthy donor (HD)-MSCs. Notably, MDS-MSCs display a senescent state, distinct morphology, and elevated secretion of senescence-associated secretory phenotype (SASP) cytokines. Mechanistically, loss of programmed cell death ligand 1 (PDL1) in MDS-MSCs correlates with decreased SETDB1 levels and reduced H3K9me3-marked heterochromatin, leading to a more open chromatin state. This SETDB1\/H3K9me3 deficiency mediates the reduction in immunosuppressive function and the increase in SASP factors (e.g. IL-6, IL-8, MCP1), exacerbating inflamm-aging. Gene expression profiling showed stage-specific senescence and inflammation phenotypes across MDS-MSCs generations. Furthermore, H3K9me3 inhibition directly induced BM-MSC senescence. Our findings demonstrate that dysfunctional BM-MSCs, driven by PDL1-SETDB1-H3K9me3 axis disruption and consequent SASP, critically promote pathogenesis in young MDS-RAEB-1 patients.<\/jats:p>","DOI":"10.1093\/stcltm\/szag025","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:42:25Z","timestamp":1772109745000},"source":"Crossref","is-referenced-by-count":0,"title":["Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3"],"prefix":"10.1093","volume":"15","author":[{"given":"Pengju","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Zhengzhou Central Hospital Affiliated Zhengzhou University , Zhengzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Zhengzhou Central Hospital Affiliated 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