{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T18:04:40Z","timestamp":1779732280054,"version":"3.53.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"R-Bio Co., Ltd","award":["NCT04427930"],"award-info":[{"award-number":["NCT04427930"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to assess the outcomes of intra-articular injection of adipose-derived mesenchymal stem cells (ADMSC) in osteoarthritis (OA) of knee joint up to 3-year follow-up and evaluate possible factors related to the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective observational follow-up of participants from the ADMSC treatment arm of a prior phase III clinical trial. A total of 104 patients were assessed through the follow-up study for 3 years after ADMSC injection. We assessed the WOMAC and VAS for pain at 1-, 2-, and 3-year post\u2013injection and compared with baseline values. Minimal clinically important difference (MCID) was calculated, and the proportion of patients achieving MCID was evaluated at each time point. Finally, we assessed which factors may affect the outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significant improvements in WOMAC and VAS scores were observed after ADMSC injection, with these benefits sustained throughout the 1-, 2-, and 3-year follow-up. The proportion achieving MCID slightly decreased over time without statistical significance. Significant factors affecting the favorable outcomes were lower body mass index (BMI) (&amp;lt;25), higher baseline clinical scores up to 3 years after the injection. Other variables did not show the significant relation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intra-articular injection of autologous, culture-expanded ADMSC in patient with knee OA was sustained improvements observed up to 3 years in terms of WOMAC and VAS values. Moreover, patient BMI and baseline WOMAC were related to the outcomes after a single injection. Patient condition including severity of pain may affect the effect of ADMSC injection in OA knee. Clinical trial registration number: NCT04427930. This study was retrospectively registered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stcltm\/szag027","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:51:03Z","timestamp":1772283063000},"source":"Crossref","is-referenced-by-count":0,"title":["Factors affecting outcomes of intra-articular injection of autologous, culture-expanded, adipose-derived mesenchymal stem cells in knee osteoarthritis"],"prefix":"10.1093","volume":"15","author":[{"given":"Jun Bum","family":"Park","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong , Seoul 05278,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong , Seoul 05278,","place":["Korea"]},{"name":"Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University , Seoul 02447,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye-Youl","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong , Seoul 05278,","place":["Korea"]},{"name":"Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University , Seoul 02447,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3334-9180","authenticated-orcid":false,"given":"Hyobeom","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong , Seoul 05278,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4010-1063","authenticated-orcid":false,"given":"Kang-Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong , Seoul 05278,","place":["Korea"]},{"name":"Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University , Seoul 02447,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"2026052513530421400_szag027-B1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/sctm.19-0202","article-title":"Trends in mesenchymal stem cell clinical trials 2004\u20132018: is efficacy optimal in a narrow dose range?","volume":"9","author":"Kabat","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"2026052513530421400_szag027-B2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1177\/03635465211053893","article-title":"Intra-articular injection of autologous adipose-derived stem cells or stromal vascular fractions: are they effective for patients with knee osteoarthritis? 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