{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:25:45Z","timestamp":1786116345774,"version":"build-2736575974"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82160178"],"award-info":[{"award-number":["82160178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82560185"],"award-info":[{"award-number":["82560185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Reserve Talents Project of Yunnan Provincial Health Commission","award":["H-2025058"],"award-info":[{"award-number":["H-2025058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The regeneration of a functional dentin-pulp complex represents a paramount objective in regenerative endodontics. However, current strategies reliant on scaffolds and growth factors are constrained by imprecise biological signaling and inefficient stem cell guidance. To address these limitations, this study aimed to develop a precise nanomaterial-based strategy. We investigated tetrahedral DNA nanostructures (TDNs) as bioactive nanocarriers to enhance the odontogenic differentiation of human dental pulp stem cell-derived induced pluripotent stem cells (hDPSC-iPSCs) within a gelatin methacryloyl (GelMA) hydrogel system. hDPSCs were isolated from young patients\u2019 teeth, reprogrammed into iPSCs, and characterized. TDNs were synthesized, characterized, and shown to be efficiently internalized by cells. In vitro, TDN treatment significantly upregulated key odontogenic markers (DSPP and DMP-1), promoted proliferation, and enhanced migration of hDPSC-iPSCs. For in vivo assessment, TDN-pretreated hDPSC-iPSCs encapsulated in GelMA were implanted into a tooth root canal regeneration model in nude mice. The TDN group regenerated well-structured, dentin-pulp-like tissues exhibiting strong dentin sialophosphoprotein (DSPP) expression, indicative of odontogenic differentiation. Collectively, these findings demonstrate that TDNs potently direct hDPSC-iPSCs toward an odontogenic lineage and support pulp-like tissue formation within a hydrogel niche. The integrated TDN\u2013cell\u2013GelMA platform presents a novel, precise, and minimally invasive strategy for early-stage pulp-like regeneration, with promising potential for clinical translation in regenerative endodontics.<\/jats:p>","DOI":"10.1093\/stcltm\/szag052","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:31:51Z","timestamp":1778585511000},"source":"Crossref","is-referenced-by-count":0,"title":["Synergistic regulation of hDPSC-iPSCs by tetrahedral DNA nanostructures for dentin-pulp complex regeneration"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5223-6612","authenticated-orcid":false,"given":"Qiong","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Stomatology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology , Kunming 650032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology , Kunming 650032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology , Kunming 650032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First People\u2019s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology , Kunming 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