{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:56:36Z","timestamp":1786114596571,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Public cord blood (CB) banks face declining inventories worldwide, but the relative contributions of regulatory changes, declining birth rates, and infectious disease outbreaks remain unclear. We performed a retrospective analysis of 73\u00a0925 CB units submitted to a Korean public cord blood bank from 2006 to 2025, encompassing two regulatory transitions in total nucleated cell (TNC) criteria and three major outbreaks (H1N1, MERS, and COVID-19), using interrupted time series, correlation, and multivariable analyses. Of 73\u00a0925 submissions, 27\u00a0684 (37.4%) were banked. The 2011 TNC \u2265 8\u2009\u00d7\u2009108 criterion produced a moderate reduction in banking rate from 37.7% to 33.6%, while the 2021 TNC \u2265 11\u2009\u00d7\u2009108 revision caused an abrupt decline from 52.6% to 24.4%. H1N1 and MERS had minimal effects, whereas the COVID-19 period showed a sustained decline coinciding with the 2021 TNC revision. Birth decline correlated strongly with submissions (R2 = 0.94). Regulatory criteria changes were the primary driver of banking rate fluctuations, while declining births affected submission volume. Among three outbreaks, only the COVID-19 period overlapped with a sustained decline, likely reflecting concurrent regulatory change rather than the pandemic itself. CB quality and safety were maintained throughout all disruptions. These findings have direct translational implications for sustaining the global CB inventory as a critical source of hematopoietic stem cells for transplantation.<\/jats:p>","DOI":"10.1093\/stcltm\/szag059","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:26:47Z","timestamp":1781612807000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of infectious disease outbreaks and regulatory policies on cord blood banking: a two-decade single-center analysis in Korea"],"prefix":"10.1093","volume":"15","author":[{"given":"Sue","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]},{"name":"Seoul Metropolitan Government Public Cord Blood Bank (ALLCORD) , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Laboratory Medicine, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Laboratory Medicine, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Ryun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, National Medical Center , Seoul 04564,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]},{"name":"Seoul Metropolitan Government Public Cord Blood Bank (ALLCORD) , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Laboratory Medicine, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul Metropolitan Government Public Cord Blood Bank (ALLCORD) , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Obstetrics and Gynecology, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Woong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Laboratory Medicine, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1787-7509","authenticated-orcid":false,"given":"Eun Youn","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center , Seoul 07061,","place":["Republic of Korea"]},{"name":"Seoul Metropolitan Government Public Cord Blood Bank (ALLCORD) , Seoul 07061,","place":["Republic of Korea"]},{"name":"Department of Laboratory Medicine, Seoul National University College of Medicine , Seoul 03080,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026080517163779000_szag059-B1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1182\/blood-2013-02-453175","article-title":"Umbilical cord blood transplantation: the first 25 years and beyond","volume":"122","author":"Ballen","year":"2013","journal-title":"Blood"},{"key":"2026080517163779000_szag059-B2","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.bbmt.2010.08.011","article-title":"Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities","volume":"16","author":"Barker","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"2026080517163779000_szag059-B3","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1056\/NEJM198910263211707","article-title":"Hematopoietic reconstitution in a patient with Fanconi\u2019s anemia by 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