{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:15:36Z","timestamp":1788225336602,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["CIRM; DISC2-14083"],"award-info":[{"award-number":["CIRM; DISC2-14083"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation therapy is a standard-of-care oncological treatment for central nervous system (CNS) malignancies. However, as survival outcomes improve, radiation-induced injury to normal brain tissue has increased in clinical significance. CNS radiation injury is a delayed, multifactorial process characterized by impaired neurogenesis, reactive gliosis, and persistent functional deficits. Mechanistic exploration and development of effective radiation mitigators have been limited by the lack of scalable, human-relevant models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mature human iPSC-derived cortical organoids were exposed to single-dose or clinically relevant fractionated radiation (5 \u00d7 2\u2009Gy). DNA damage, apoptosis, and growth dynamics were assessed longitudinally. Structural organization, synaptic integrity, and neuroinflammatory responses were evaluated by immunofluorescence and real-time PCR. Transcriptomic profiling was performed at 72\u2009hours and 2\u2009weeks after fractionated radiation to capture acute and delayed effects. Two candidate radiation mitigators, NSPP and amisulpride, were tested for their therapeutic effects within the organoid system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cortical organoids exhibited partial recovery following single doses up to 4\u2009Gy or fractioned irradiation. Transcriptomic analyses revealed that radiation not only reduced overall cell viability but also reshaped lineage trajectories, characterized by depletion of neural stem\/progenitor populations, loss of neuronal identity, enhanced gliogenesis, increased inflammatory cytokines, and disrupted cortical layering and synaptic integrity. Treatment with NSPP or amisulpride attenuated injury-associated transcriptional and structural alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Human cortical organoids recapitulate key features of radiation-induced neural injury, recovery, and therapeutic modulation, providing a robust, scalable, and human-relevant platform for studying CNS radiation biology and preclinical screening of candidate radiation mitigators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stcltm\/szag071","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:39:43Z","timestamp":1784893183000},"source":"Crossref","is-referenced-by-count":0,"title":["Temporal mapping of radiation-induced neural injury and mitigation in human cortical organoids"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-7530","authenticated-orcid":false,"given":"Ling","family":"He","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-4540","authenticated-orcid":false,"given":"Harley I","family":"Kornblum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Human Behavior, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]},{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-6899","authenticated-orcid":false,"given":"Aparna","family":"Bhaduri","sequence":"additional","affiliation":[{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]},{"name":"Department of Biological Chemistry, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-9751","authenticated-orcid":false,"given":"Frank","family":"Pajonk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]},{"name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]},{"name":"Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA 90095,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026083120521133900_szag071-B1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fonc.2012.00073","article-title":"Radiation-induced brain injury: a review","volume":"2","author":"Greene-Schloesser","year":"2012","journal-title":"Front Oncol"},{"key":"2026083120521133900_szag071-B2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1667\/0033-7587(2000)153[0357:TROTCN]2.0.CO;2","article-title":"The radioresponse of the central nervous system: a dynamic process","volume":"153","author":"Tofilon","year":"2000","journal-title":"Radiat Res"},{"key":"2026083120521133900_szag071-B3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(94)92997-1","article-title":"Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. ISPACC. International Study Group on Psychosocial Aspects of Childhood Cancer","volume":"344","author":"Jankovic","year":"1994","journal-title":"Lancet"},{"key":"2026083120521133900_szag071-B4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1182\/blood-2013-03-487744","article-title":"Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation","volume":"122","author":"Krull","year":"2013","journal-title":"Blood"},{"key":"2026083120521133900_szag071-B5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jagp.2017.04.001","article-title":"Cognitive effects of chemotherapy and cancer-related treatments in older adults","volume":"25","author":"Vega","year":"2017","journal-title":"Am J Geriatr Psychiatry"},{"key":"2026083120521133900_szag071-B6","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2147\/CMAR.S441360","article-title":"Radiation-induced cognitive decline: challenges and solutions","volume":"16","author":"Shamsesfandabadi","year":"2024","journal-title":"Cancer Manag Res"},{"key":"2026083120521133900_szag071-B7","doi-asserted-by":"crossref","first-page":"312","DOI":"10.21037\/apm-20-2284","article-title":"Mitigation of acute radiation-induced brain injury in a mouse model using anlotinib","volume":"10","author":"Gao","year":"2021","journal-title":"Ann Palliat Med"},{"key":"2026083120521133900_szag071-B8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1667\/RR14847.1","article-title":"Behavioral effects of focal irradiation in a juvenile murine model","volume":"189","author":"Alexander","year":"2018","journal-title":"Radiat Res"},{"key":"2026083120521133900_szag071-B9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.18632\/aging.100587","article-title":"Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production","volume":"5","author":"Suman","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"2026083120521133900_szag071-B10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3390\/ijms25010337","article-title":"Delayed reaction of radiation on the central nervous system and bone system in C57BL\/6J mice","volume":"25","author":"Ru","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026083120521133900_szag071-B11","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.ijrobp.2006.06.043","article-title":"Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes","volume":"66","author":"Yuan","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026083120521133900_szag071-B12","doi-asserted-by":"crossref","first-page":"100245","DOI":"10.1016\/j.ynirp.2025.100245","article-title":"Radiation-induced brain injury in non-human primates: a dual tracer PET study with [(11)C]MPC-6827 and [(11)C]PiB","volume":"5","author":"Damuka","year":"2025","journal-title":"Neuroimage Rep"},{"key":"2026083120521133900_szag071-B13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/17460441.2017.1323863","article-title":"Nonhuman primates as models for the discovery and development of radiation countermeasures","volume":"12","author":"Singh","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"2026083120521133900_szag071-B14","first-page":"9","article-title":"Nonhuman primate models in the study of spaceflight stressors: past contributions and future directions","volume":"30","author":"Desai","year":"2021","journal-title":"Life Sci Space Res (Amst)"},{"key":"2026083120521133900_szag071-B15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1667\/RR2497.1","article-title":"A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates","volume":"175","author":"Robbins","year":"2011","journal-title":"Radiat Res"},{"key":"2026083120521133900_szag071-B16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41586-019-1506-7","article-title":"Conserved cell types with divergent features in human versus mouse cortex","volume":"573","author":"Hodge","year":"2019","journal-title":"Nature"},{"key":"2026083120521133900_szag071-B17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41580-024-00804-1","article-title":"Modelling human brain development and disease with organoids","volume":"26","author":"Birtele","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026083120521133900_szag071-B18","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1038\/nprot.2014.158","article-title":"Generation of cerebral organoids from human pluripotent stem cells","volume":"9","author":"Lancaster","year":"2014","journal-title":"Nat Protoc"},{"key":"2026083120521133900_szag071-B19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"2026083120521133900_szag071-B20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-020-1962-0","article-title":"Cell stress in cortical organoids impairs molecular subtype specification","volume":"578","author":"Bhaduri","year":"2020","journal-title":"Nature"},{"key":"2026083120521133900_szag071-B21","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2019.01.017","article-title":"Establishing cerebral organoids as models of human-specific brain evolution","volume":"176","author":"Pollen","year":"2019","journal-title":"Cell"},{"key":"2026083120521133900_szag071-B22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41586-019-1289-x","article-title":"Individual brain organoids reproducibly form cell diversity of the human cerebral cortex","volume":"570","author":"Velasco","year":"2019","journal-title":"Nature"},{"key":"2026083120521133900_szag071-B23","doi-asserted-by":"crossref","first-page":"20284","DOI":"10.1073\/pnas.1315710110","article-title":"Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex","volume":"110","author":"Kadoshima","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026083120521133900_szag071-B24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.stem.2019.11.015","article-title":"Outer radial glia-like cancer stem cells contribute to heterogeneity of glioblastoma","volume":"26","author":"Bhaduri","year":"2020","journal-title":"Cell Stem Cell"},{"key":"2026083120521133900_szag071-B25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat Biotechnol"},{"key":"2026083120521133900_szag071-B26","doi-asserted-by":"publisher","author":"Fazzari","year":"2024","DOI":"10.1101\/2024.07.24.604840"},{"key":"2026083120521133900_szag071-B27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"key":"2026083120521133900_szag071-B28","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/s41467-025-57047-7","article-title":"Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy","volume":"16","author":"Sanborn","year":"2025","journal-title":"Nat Commun"},{"key":"2026083120521133900_szag071-B29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-025-02375-9","article-title":"Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs","volume":"10","author":"Shang","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026083120521133900_szag071-B30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/neuonc\/nox195","article-title":"Radiation-induced cognitive toxicity: pathophysiology and interventions to reduce toxicity in adults","volume":"20","author":"Wilke","year":"2018","journal-title":"Neuro Oncol"},{"key":"2026083120521133900_szag071-B31","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat Biotechnol"},{"key":"2026083120521133900_szag071-B32","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/neuonc\/noaa095","article-title":"1-[(4-Nitrophenyl)sulfonyl]-4-phenylpiperazine treatment after brain irradiation preserves cognitive function in mice","volume":"22","author":"Bhat","year":"2020","journal-title":"Neuro Oncol"},{"key":"2026083120521133900_szag071-B33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/sctm.19-0136","article-title":"Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine","volume":"9","author":"Duhachek-Muggy","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"2026083120521133900_szag071-B34","doi-asserted-by":"crossref","first-page":"110562","DOI":"10.1016\/j.radonc.2024.110562","article-title":"Effects of dopamine receptor antagonists and radiation on mouse neural stem\/progenitor cells","volume":"201","author":"He","year":"2024","journal-title":"Radiother Oncol"},{"key":"2026083120521133900_szag071-B35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.rpor.2011.06.001","article-title":"Radiobiology of the acute radiation syndrome","volume":"16","author":"Macia","year":"2011","journal-title":"Rep Pract Oncol Radiother"},{"key":"2026083120521133900_szag071-B36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm749","article-title":"Irradiation induces neural precursor-cell dysfunction","volume":"8","author":"Monje","year":"2002","journal-title":"Nat Med"},{"key":"2026083120521133900_szag071-B37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.radonc.2016.10.003","article-title":"Dose-dependent white matter damage after brain radiotherapy","volume":"121","author":"Connor","year":"2016","journal-title":"Radiother Oncol"},{"key":"2026083120521133900_szag071-B38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11060-012-0821-8","article-title":"Changes in neurocognitive functioning and quality of life in adult patients with brain tumors treated with radiotherapy","volume":"108","author":"Scoccianti","year":"2012","journal-title":"J Neurooncol"},{"key":"2026083120521133900_szag071-B39","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/dmm.026120","article-title":"Rodent models in neuroscience research: is it a rat race?","volume":"9","author":"Ellenbroek","year":"2016","journal-title":"Dis Model Mech"},{"key":"2026083120521133900_szag071-B40","doi-asserted-by":"crossref","DOI":"10.1242\/dev.166074","article-title":"Brain organoids: advances, applications and challenges","volume":"146","author":"Qian","year":"2019","journal-title":"Development"},{"key":"2026083120521133900_szag071-B41","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn.2017.107","article-title":"The use of brain organoids to investigate neural development and disease","volume":"18","author":"Di Lullo","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"2026083120521133900_szag071-B42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.stemcr.2020.12.019","article-title":"Cell-to-cell adhesion and neurogenesis in human cortical development: a study comparing 2D monolayers with 3D organoid cultures","volume":"16","author":"Scuderi","year":"2021","journal-title":"Stem Cell Rep"},{"key":"2026083120521133900_szag071-B43","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2014.12.060","article-title":"The outer subventricular zone and primate-specific cortical complexification","volume":"85","author":"Dehay","year":"2015","journal-title":"Neuron"},{"key":"2026083120521133900_szag071-B44","doi-asserted-by":"crossref","first-page":"102777","DOI":"10.1016\/j.stemcr.2025.102777","article-title":"Differential synaptic signaling responses in human cortical organoids after photon and proton irradiation","volume":"21","author":"Jiang","year":"2026","journal-title":"Stem Cell Rep"},{"key":"2026083120521133900_szag071-B45","doi-asserted-by":"crossref","first-page":"1335849","DOI":"10.3389\/fncel.2024.1335849","article-title":"Reactive gliosis in traumatic brain injury: a comprehensive review","volume":"18","author":"Amlerova","year":"2024","journal-title":"Front Cell Neurosci"},{"key":"2026083120521133900_szag071-B46","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4103\/NRR.NRR-D-23-02091","article-title":"Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury","volume":"20","author":"Cieri","year":"2025","journal-title":"Neural Regen Res"},{"key":"2026083120521133900_szag071-B47","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s12035-013-8460-4","article-title":"Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury","volume":"48","author":"Gao","year":"2013","journal-title":"Mol Neurobiol"},{"key":"2026083120521133900_szag071-B48","doi-asserted-by":"crossref","first-page":"e1481","DOI":"10.1038\/cddis.2014.446","article-title":"A smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury","volume":"5","author":"Chechneva","year":"2014","journal-title":"Cell Death Dis"},{"key":"2026083120521133900_szag071-B49","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/1673-5374.153677","article-title":"Empowering sonic hedgehog to rescue brain cells after ischemic stroke","volume":"10","author":"Chechneva","year":"2015","journal-title":"Neural Regen Res"},{"key":"2026083120521133900_szag071-B50","doi-asserted-by":"crossref","first-page":"e71187","DOI":"10.1096\/fj.202502571R","article-title":"Smoothened agonist treatment mitigates vasogenic edema, neuroinflammation, and neurological dysfunction following traumatic brain injury in mice","volume":"39","author":"Michinaga","year":"2025","journal-title":"FASEB J"},{"key":"2026083120521133900_szag071-B51","doi-asserted-by":"crossref","first-page":"9762592","DOI":"10.1155\/2021\/9762592","article-title":"Neuroprotective effects of the sonic hedgehog signaling pathway in ischemic injury through promotion of synaptic and neuronal health","volume":"2021","author":"Yin","year":"2021","journal-title":"Neural Plast"},{"key":"2026083120521133900_szag071-B52","doi-asserted-by":"crossref","first-page":"104418","DOI":"10.1016\/j.etap.2024.104418","article-title":"Role of prolactin in the protective effect of amisulpride against 1,2-Diacetylbenzene\u2019s neurotoxicity","volume":"107","author":"Hoang","year":"2024","journal-title":"Environ Toxicol Pharmacol"},{"key":"2026083120521133900_szag071-B53","doi-asserted-by":"crossref","first-page":"614811","DOI":"10.3389\/fphar.2021.614811","article-title":"Cannabidiol and amisulpride improve cognition in acute schizophrenia in an explorative, double-blind, active-controlled, randomized clinical trial","volume":"12","author":"Leweke","year":"2021","journal-title":"Front Pharmacol"},{"key":"2026083120521133900_szag071-B54","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1002\/alz.13090","article-title":"Amisulpride as a potential disease-modifying drug in the treatment of tauopathies","volume":"19","author":"Jahreis","year":"2023","journal-title":"Alzheimers Dement"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/15\/9\/szag071\/70885448\/szag071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/15\/9\/szag071\/70885448\/szag071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:52:26Z","timestamp":1788223946000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/doi\/10.1093\/stcltm\/szag071\/8777126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,18]]}},"URL":"https:\/\/doi.org\/10.1093\/stcltm\/szag071","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,18]]},"article-number":"szag071"}}