{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:28:28Z","timestamp":1786321708760,"version":"build-2736575974"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fulbright Fellowship"},{"DOI":"10.13039\/100012256","name":"Research Foundation of Cerebral Palsy Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Cord blood infusion is an emerging treatment for cerebral palsy (CP) currently offered in the United States through clinical trials and an expanded access pathway. This study aimed to understand the barriers and facilitators influencing implementation of cord blood treatment for CP, to help inform future implementation efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Semi-structured interviews were conducted with US professionals involved in the cord blood treatment program for CP at Duke University and a collaborator site. Data were analyzed using reflexive thematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 16 interviews, 5 themes were identified capturing patterned barriers and enablers. Key facilitators included boundary-spanning clinical leadership, interprofessional coordination, dedicated resourcing, responsiveness to community demand, an established safety profile, and a strong research culture. Barriers included the need for cross-disciplinary expertise, uncertainty regarding efficacy evidence, funding and regulatory constraints, and system-level challenges. Participants described that many barriers were overcome to establish the program, while acknowledging that others may persist and are context dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings highlight that implementation of cord blood treatment for CP is feasible within specialized settings but contingent on local infrastructure, governance, and workforce capacity. Identified facilitators align with established implementation strategies and offer transferable insights, while underscoring the need for regulatory approval, ethical oversight, and system-level supports to enable equitable and sustainable access to emerging regenerative therapies for CP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stcltm\/szag074","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:18:01Z","timestamp":1785237481000},"source":"Crossref","is-referenced-by-count":0,"title":["From evidence to practice: factors influencing the implementation of cord blood treatment for cerebral palsy in the United States"],"prefix":"10.1093","volume":"15","author":[{"given":"Madison C B","family":"Paton","sequence":"first","affiliation":[{"name":"Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney Cerebral Palsy Alliance Research Institute, , Camperdown, NSW 2050,","place":["Australia"]},{"name":"Department of Paediatrics, School of Clinical Sciences at Monash Health, Monash University , Clayton, VIC 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-0703","authenticated-orcid":false,"given":"Joanne","family":"Kurtzberg","sequence":"additional","affiliation":[{"name":"The Marcus Center for Cellular Cures, Duke University School of Medicine , Durham, NC 27705,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Sun","sequence":"additional","affiliation":[{"name":"The Marcus Center for Cellular Cures, Duke University School of Medicine , Durham, NC 27705,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-5649","authenticated-orcid":false,"given":"Sarah","family":"Reedman","sequence":"additional","affiliation":[{"name":"Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney Cerebral Palsy Alliance Research Institute, , Camperdown, NSW 2050,","place":["Australia"]},{"name":"Queensland Cerebral Palsy and Rehabilitation Research Centre, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland , South Brisbane, QLD 4101,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Blatch-Williams","sequence":"additional","affiliation":[{"name":"Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney Cerebral Palsy Alliance Research Institute, , Camperdown, NSW 2050,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fahey","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, School of Clinical Sciences at Monash Health, Monash University , Clayton, VIC 3168,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona","family":"Novak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney , Camperdown, NSW 2006,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-5842","authenticated-orcid":false,"given":"Megan","family":"Finch-Edmondson","sequence":"additional","affiliation":[{"name":"Specialty of Child and Adolescent Health, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney Cerebral Palsy Alliance Research Institute, , Camperdown, NSW 2050,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"2026080919385876900_szag074-B1","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/dmcn.16274","article-title":"Proposed updated description of cerebral palsy","volume":"67","author":"Dan","year":"2025","journal-title":"Dev Med Child Neurol"},{"key":"2026080919385876900_szag074-B2","doi-asserted-by":"publisher","first-page":"7368","DOI":"10.3390\/jcm11247368","article-title":"Persistent inflammation in cerebral palsy: pathogenic mediator or comorbidity? 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