{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:21:38Z","timestamp":1793449298654,"version":"4.5.0"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL146128"],"award-info":[{"award-number":["R01 HL146128"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 AI134025"],"award-info":[{"award-number":["R21 AI134025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the past decades, substantial advances in neonatal medical care have increased the survival of extremely premature infants. However, there continues to be significant morbidity associated with preterm birth with common complications including bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), neuronal injury such as intraventricular hemorrhage (IVH) or hypoxic ischemic encephalopathy (HIE), as well as retinopathy of prematurity (ROP). Common developmental immune and inflammatory pathways underlie the pathophysiology of such complications providing the opportunity for multisystem therapeutic approaches. To date, no single therapy has proven to be effective enough to prevent or treat the sequelae of prematurity. In the past decade mesenchymal stem\/stromal cell (MSC)\u2014based therapeutic approaches have shown promising results in numerous experimental models of neonatal diseases. It is now accepted that the therapeutic potential of MSCs is comprised of their secretome, and several studies have recognized the small extracellular vesicles (sEVs) as the paracrine vector. Herein, we review the current literature on the MSC-EVs as potential therapeutic agents in neonatal diseases and comment on the progress and challenges of their translation to the clinical setting.<\/jats:p>","DOI":"10.1093\/stmcls\/sxac062","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T16:38:27Z","timestamp":1661963907000},"page":"991-1007","source":"Crossref","is-referenced-by-count":21,"title":["Mesenchymal Stromal\/Stem Cell Extracellular Vesicles and Perinatal Injury: One Formula for Many Diseases"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-4854","authenticated-orcid":false,"given":"Eleni","family":"Delavogia","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, MA , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P","family":"Ntentakis","sequence":"additional","affiliation":[{"name":"Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Cortinas","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, MA , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-9128","authenticated-orcid":false,"given":"Angeles","family":"Fernandez-Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, MA , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Alex Mitsialis","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, MA , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Kourembanas","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics, Boston Children\u2019s Hospital , Boston, MA , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"issue":"1","key":"2022112912202820100_CIT0001","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and 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