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Currently, IFN-\u03b3 licensing received the most attention in comparison with other cytokines.<\/jats:p>\n               <jats:p>After licensing human bone marrow-derived MSCs with pro-\/anti-inflammatory cytokines IFN-\u03b3, IL-1\u03b2, TNF-\u03b1, TGF-\u03b21 alone or in combination, the in vitro immunomodulatory potency of these MSCs was studied by incubating with allogeneic T cells and macrophage-like THP-1 cells. In addition, immunomodulation-related molecules filtered by bioinformatics, complement 1 subcomponent (C1s), and interferon-induced GTP-binding protein Mx2 (MX2), were studied to verify whether to reflect the immunomodulatory potency.<\/jats:p>\n               <jats:p>Herein, we reported that different cytokines cause different effects on the function of MSC. While TGF-\u03b21 licensing enhances the capacity of MSCs to induce T cells with an immunosuppressive phenotype, IFN-\u03b3-licensing strengthens the inhibitory effect of MSC on T cell proliferation. Both TGF-\u03b21 and IFN-\u03b3 licensing can enhance the effect of MSC on reducing the expression of pro-inflammatory cytokines by M1 macrophage-like THP-1 cells. Interestingly, IFN-\u03b3 upregulates potential potency markers extracellular C1s and kynurenine (KYN) and intracellular MX2. These 3 molecules have the potential to reflect mesenchymal stromal cell immunomodulatory potency. In addition, we reported that there is a synergistic effect of TGF-\u03b21 and IFN-\u03b3 in immunomodulation.<\/jats:p>","DOI":"10.1093\/stmcls\/sxae053","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T22:10:54Z","timestamp":1724969454000},"page":"1040-1054","source":"Crossref","is-referenced-by-count":18,"title":["Immunomodulatory potential of cytokine-licensed human bone marrow-derived mesenchymal stromal cells correlates with potency marker expression profile"],"prefix":"10.1093","volume":"42","author":[{"given":"Jiemin","family":"Wang","sequence":"first","affiliation":[{"name":"Regenerative Medicine Institute, School of Medicine, University of Galway , Galway H91FD82 ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Changsha Centre for Disease Control and Prevention , Changsha, Hunan Province 410011 ,","place":["People\u2019s 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