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We developed a pretreatment strategy for BMSCs to improve their viability. In a rat model of MPS-induced ONFH, we evaluated the effects of USP13 overexpression in BMSCs through micro-CT, HE staining, and TUNEL staining. USP13-overexpressing BMSCs significantly reduced ONFH severity compared to plain BMSCs and direct lentivirus injection. USP13 also protected BMSCs from MPS-induced apoptosis by modulating PTEN and reducing AKT phosphorylation. This led to decreased expression of apoptotic genes and proteins in USP13-overexpressing BMSCs. Our findings highlight USP13 as a promising target for enhancing BMSC survival and efficacy in treating MPS-induced ONFH.<\/jats:p>","DOI":"10.1093\/stmcls\/sxae069","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T10:26:02Z","timestamp":1729938362000},"source":"Crossref","is-referenced-by-count":4,"title":["USP13 overexpression in BMSCs enhances anti-apoptotic ability and guards against methylprednisolone-induced osteonecrosis in rats"],"prefix":"10.1093","volume":"43","author":[{"given":"Yixin","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Nanjing Agricultural University Department of Veterinary Clinical Sciences, , Nanjing 210095 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Nanjing Agricultural University Department of Veterinary 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