{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:58:39Z","timestamp":1779249519523,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0030286"],"award-info":[{"award-number":["NNF18OC0030286"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSCReconstruct","award":["874758"],"award-info":[{"award-number":["874758"]}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R336-2019-2927"],"award-info":[{"award-number":["R336-2019-2927"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF21CC0073729"],"award-info":[{"award-number":["NNF21CC0073729"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cell replacement therapies using human pluripotent stem cell-derived ventral midbrain (VM) dopaminergic (DA) progenitors are currently in clinical trials for treatment of Parkinson\u2019s disease (PD). Recapitulating developmental patterning cues, such as fibroblast growth factor 8 (FGF8), secreted at the midbrain-hindbrain boundary (MHB), is critical for the in vitro production of authentic VM DA progenitors. Here, we explored the application of alternative MHB-secreted FGF-family members, FGF17 and FGF18, for VM DA progenitor patterning. We show that while FGF17 and FGF18 both recapitulated VM DA progenitor patterning events, FGF17 induced expression of key VM DA progenitor markers at higher levels than FGF8 and transplanted FGF17-patterned progenitors fully reversed motor deficits in a rat PD model. Early activation of the cAMP pathway mimicked FGF17-induced patterning, although strong cAMP activation came at the expense of EN1 expression. In summary, we identified FGF17 as a promising alternative FGF candidate for robust VM DA progenitor patterning.<\/jats:p>","DOI":"10.1093\/stmcls\/sxaf004","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T23:17:12Z","timestamp":1739834232000},"source":"Crossref","is-referenced-by-count":4,"title":["Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson\u2019s disease"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4376-8679","authenticated-orcid":false,"given":"Amalie","family":"Holm Nygaard","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alrik L","family":"Sch\u00f6rling","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]},{"name":"Department of Experimental Medical Sciences, Wallenberg Center for Molecular Medicine (WCMM) and Lund Stem Cell Center, Lund University , SE-221 84 Lund,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Abay-N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erno","family":"H\u00e4nninen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Sciences, Wallenberg Center for Molecular Medicine (WCMM) and Lund Stem Cell Center, Lund University , SE-221 84 Lund,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ram\u00f3n Santonja","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav Singh","family":"Rathore","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Salvador","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Rusimbi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine Bech","family":"Lauritzen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Sciences, Wallenberg Center for Molecular Medicine (WCMM) and Lund Stem Cell Center, Lund University , SE-221 84 Lund,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-6901","authenticated-orcid":false,"given":"Agnete","family":"Kirkeby","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Department of Biomedical Sciences,\u00a0Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]},{"name":"Department of Experimental Medical Sciences, Wallenberg Center for Molecular Medicine (WCMM) and Lund Stem Cell Center, Lund University , SE-221 84 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