{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:55:13Z","timestamp":1792853713488,"version":"4.5.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01s: HL114120"],"award-info":[{"award-number":["R01s: HL114120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL131017"],"award-info":[{"award-number":["HL131017"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL 149137"],"award-info":[{"award-number":["HL 149137"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH U01 HL134764"],"award-info":[{"award-number":["NIH U01 HL134764"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH P01 HL160476"],"award-info":[{"award-number":["NIH P01 HL160476"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01s: HL147954"],"award-info":[{"award-number":["NIH R01s: HL147954"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL164584"],"award-info":[{"award-number":["HL164584"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL169432"],"award-info":[{"award-number":["HL169432"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>When pigs underwent apical resection (AR) on postnatal day (P) 1 (ARP1) followed by myocardial infarction (MI) on P28, the hearts had little evidence of scarring; meanwhile, hearts underwent MI on P28 without ARP1 showed large infarcts on P56; and the improvement of ARP1 hearts was driven primarily by cardiomyocyte proliferation. AR and MI were performed ~5\u00a0mm (AR) and ~20\u00a0mm (MI) above the heart apex; thus, we hypothesize that ARP1 preserved the cardiomyocytes cell-cycle throughout the left ventricle, rather than only near the resection site.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sections of cardiac tissue were collected from the left ventricle of uninjured pigs and from both the border zone (BZ) of AR and uninjured regions (remote zone, [RZ]) in ARP1 hearts. Cardiomyocyte proliferation was evaluated via immunofluorescence analysis of phosphorylated histone 3 [PH3] and symmetric Aurora B (sAuB). Single nucleus RNA sequencing (snRNAseq) data collected from the hearts of fetal pigs, uninjured pigs, and the BZ and RZ of ARP1 pigs was evaluated via our cell-cycle-specific autoencoder to identify proliferating cardiomyocytes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cardiomyocyte PH3 and sAuB expression, and percentage of proliferating cardiomyocytes in snRNA data was significantly more common in both BZ and RZ of ARP1 than uninjured hearts but did not differ significantly between the ARP1-BZ and ARP1-RZ at any time point. Heat shock proteins HSPA5 and HSP90B1 were overexpressed at both ARP1-BZ and ARP1-RZ. In AC16 cell, overexpression (and knockdown) of HSPA5-HSP90B1 increased (and decrease) cell-cycle activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>ARP1 preserved proliferative capacity of cardiomyocytes located throughout the left ventricle.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/stmcls\/sxaf018","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T04:52:41Z","timestamp":1744692761000},"source":"Crossref","is-referenced-by-count":2,"title":["Newborn apical resection preserves the proliferative capacity of cardiomyocytes located throughout the left ventricle"],"prefix":"10.1093","volume":"43","author":[{"given":"Kaili","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8440-1594","authenticated-orcid":false,"given":"Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Walcott","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8970-7365","authenticated-orcid":false,"given":"Daniel J","family":"Garry","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of Minnesota , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-3967","authenticated-orcid":false,"given":"Peng","family":"Yao","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Biochemistry & Biophysics, The Center for RNA Biology, School of Medicine, University of Rochester , Rochester, NY 14642 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3955-6554","authenticated-orcid":false,"given":"Jianyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]},{"name":"Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham , Birmingham, AL 35294 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"2025052712182468400_CIT0001","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1161\/CIRCULATIONAHA.121.056995","article-title":"Single nucleus transcriptomics: apical resection in newborn pigs extends the time window of cardiomyocyte proliferation and myocardial regeneration","volume":"145","author":"Nakada","year":"2022","journal-title":"Circulation."},{"key":"2025052712182468400_CIT0002","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1161\/CIRCULATIONAHA.118.034886","article-title":"Regenerative potential of neonatal porcine hearts","volume":"138","author":"Zhu","year":"2018","journal-title":"Circulation."},{"key":"2025052712182468400_CIT0003","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","article-title":"Early regenerative capacity in the porcine heart","volume":"138","author":"Ye","year":"2018","journal-title":"Circulation."},{"key":"2025052712182468400_CIT0004","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1161\/CIRCULATIONAHA.119.044619","article-title":"Apical resection prolongs the cell cycle activity and promotes myocardial regeneration after left ventricular injury in neonatal pig","volume":"142","author":"Zhao","year":"2020","journal-title":"Circulation."},{"key":"2025052712182468400_CIT0005","doi-asserted-by":"publisher","first-page":"914450","DOI":"10.3389\/fbioe.2022.914450","article-title":"Cardiomyocyte cell-cycle regulation in neonatal large mammals: single nucleus RNA-sequencing data analysis via an artificial-intelligence-based pipeline","volume":"10","author":"Nguyen","year":"2022","journal-title":"Front Bioeng Biotechnol."},{"key":"2025052712182468400_CIT0006","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/stmcls\/sxae016","article-title":"Cell-cycle\u2013specific autoencoding improves cluster analysis of cycling cardiomyocytes","volume":"42","author":"Nguyen","year":"2024","journal-title":"Stem Cells."},{"key":"2025052712182468400_CIT0007","doi-asserted-by":"publisher","first-page":"6821","DOI":"10.1038\/s41598-023-32293-1","article-title":"Analysis of cardiac single-cell RNA-sequencing data can be improved by the use of artificial-intelligence-based tools","volume":"13","author":"Nguyen","year":"2023","journal-title":"Sci Rep."},{"key":"2025052712182468400_CIT0008","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.devcel.2020.11.006","article-title":"Dynamic transcriptional responses to injury of regenerative and non-regenerative cardiomyocytes revealed by single-nucleus RNA sequencing","volume":"55","author":"Cui","year":"2020","journal-title":"Dev Cell."},{"key":"2025052712182468400_CIT0009","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science."},{"key":"2025052712182468400_CIT0010","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.yjmcc.2014.12.011","article-title":"A systematic analysis of neonatal mouse heart regeneration after apical resection","volume":"79","author":"Bryant","year":"2015","journal-title":"J Mol Cell Cardiol."},{"key":"2025052712182468400_CIT0011","author":"Gene Ontology: Chromosome, Centromeric Region","year":"2024"},{"key":"2025052712182468400_CIT0012","author":"Gene Ontology: Kinetochore","year":"2024"},{"key":"2025052712182468400_CIT0013","author":"Gene Ontology: Midbody","year":"2024"},{"key":"2025052712182468400_CIT0014","author":"Gene Ontology: Chromatin Remodeling","year":"2024"},{"key":"2025052712182468400_CIT0015","doi-asserted-by":"publisher","first-page":"101109","DOI":"10.1016\/j.redox.2019.101109","article-title":"HIF-1alpha protects against oxidative stress by directly targeting mitochondria","volume":"25","author":"Li","year":"2019","journal-title":"Redox Biol."},{"key":"2025052712182468400_CIT0016","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature."},{"key":"2025052712182468400_CIT0017","doi-asserted-by":"publisher","first-page":"108089","DOI":"10.1016\/j.celrep.2020.108089","article-title":"Tp53 suppression promotes cardiomyocyte proliferation during zebrafish heart regeneration","volume":"32","author":"Shoffner","year":"2020","journal-title":"Cell Rep"},{"key":"2025052712182468400_CIT0018","doi-asserted-by":"publisher","first-page":"480","DOI":"10.33594\/000000152","article-title":"C-Terminal HSP90 inhibitors block the HIF-1 hypoxic response by degrading HIF-1alpha through the oxygen-dependent degradation pathway","volume":"53","author":"Kataria","year":"2019","journal-title":"Cell Physiol Biochem."},{"key":"2025052712182468400_CIT0019","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/s0014-5793(99)01359-9","article-title":"Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction","volume":"460","author":"Minet","year":"1999","journal-title":"FEBS Lett."},{"key":"2025052712182468400_CIT0020","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3892\/ijmm.2016.2482","article-title":"HSP90 inhibits apoptosis and promotes growth by regulating HIF-1alpha abundance in hepatocellular carcinoma","volume":"37","author":"Liu","year":"2016","journal-title":"Int J Mol Med."},{"key":"2025052712182468400_CIT0021","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/s41417-021-00316-6","article-title":"Heat shock protein-90alpha (Hsp90alpha) stabilizes hypoxia-inducible factor-1alpha (HIF-1alpha) in support of spermatogenesis and tumorigenesis","volume":"28","author":"Tang","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"2025052712182468400_CIT0022","doi-asserted-by":"publisher","first-page":"26480","DOI":"10.18632\/oncotarget.8419","article-title":"FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation","volume":"7","author":"Luo","year":"2016","journal-title":"Oncotarget"},{"key":"2025052712182468400_CIT0023","doi-asserted-by":"publisher","first-page":"626836","DOI":"10.3389\/fonc.2020.626836","article-title":"FOXM1 and cancer: faulty cellular signaling derails homeostasis","volume":"10","author":"Kalathil","year":"2020","journal-title":"Front Oncol."},{"key":"2025052712182468400_CIT0024","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3892\/or.2019.7248","article-title":"Transcriptional regulation of FoxM1 by HIF-1alpha mediates hypoxia\u2011induced EMT in prostate cancer","volume":"42","author":"Tang","year":"2019","journal-title":"Oncol Rep."},{"key":"2025052712182468400_CIT0025","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.3390\/ijms24065144","article-title":"HSPA5 promotes the proliferation, metastasis and regulates ferroptosis of bladder cancer","volume":"24","author":"Wang","year":"2023","journal-title":"Int J Mol Sci."},{"key":"2025052712182468400_CIT0026","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 regulates ferroptotic cell death in cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"key":"2025052712182468400_CIT0027","author":"Interpreting Results: Mann-Whitney Test","year":"2024"},{"key":"2025052712182468400_CIT0028","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1161\/CIRCULATIONAHA.120.049497","article-title":"Cyclin D2 overexpression enhances the efficacy of human induced pluripotent stem cell-derived cardiomyocytes for myocardial repair in a swine model of myocardial infarction","volume":"144","author":"Zhao","year":"2021","journal-title":"Circulation."},{"key":"2025052712182468400_CIT0029","doi-asserted-by":"publisher","first-page":"673621","DOI":"10.3389\/fphar.2021.673621","article-title":"miR-199a overexpression enhances the potency of human induced-pluripotent stem-cell-derived cardiomyocytes for myocardial repair","volume":"12","author":"Bian","year":"2021","journal-title":"Front Pharmacol."},{"key":"2025052712182468400_CIT0030","doi-asserted-by":"publisher","first-page":"1257669","DOI":"10.3389\/fbioe.2023.1257669","article-title":"Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal transition in regenerating pig hearts","volume":"11","author":"Nguyen","year":"2023","journal-title":"Front Bioeng Biotechnol."},{"key":"2025052712182468400_CIT0031","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.4103\/2153-3539.92034","article-title":"A comparison of sampling strategies for histological image analysis","volume":"2","author":"Homeyer","year":"2011","journal-title":"J Pathol Inform"},{"key":"2025052712182468400_CIT0032","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev-biophys-111622-091309","article-title":"Mechanisms of protein quality control in the endoplasmic reticulum by a coordinated Hsp40-Hsp70-Hsp90 system","volume":"52","author":"Kotler","year":"2023","journal-title":"Annu Rev Biophys."},{"key":"2025052712182468400_CIT0033","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/j.celrep.2016.06.084","article-title":"The cardiomyocyte RNA-binding proteome: links to intermediary metabolism and heart disease","volume":"16","author":"Liao","year":"2016","journal-title":"Cell Rep"},{"key":"2025052712182468400_CIT0034","doi-asserted-by":"publisher","first-page":"10127","DOI":"10.1038\/ncomms10127","article-title":"The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs","volume":"6","author":"Beckmann","year":"2015","journal-title":"Nat Commun."},{"key":"2025052712182468400_CIT0035","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1074\/mcp.M115.056564","article-title":"Identification of RNA-binding proteins in macrophages by interactome capture","volume":"15","author":"Liepelt","year":"2016","journal-title":"Mol Cell Proteomics."},{"key":"2025052712182468400_CIT0036","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1161\/CIRCRESAHA.119.315999","article-title":"Glutamyl-Prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis","volume":"127","author":"Wu","year":"2020","journal-title":"Circ Res."},{"key":"2025052712182468400_CIT0037","doi-asserted-by":"publisher","first-page":"6618","DOI":"10.1093\/nar\/gkac519","article-title":"Anatomy of four human argonaute proteins","volume":"50","author":"Nakanishi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2025052712182468400_CIT0038","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41435-023-00205-y","article-title":"Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease","volume":"24","author":"Rehati","year":"2023","journal-title":"Genes Immun."},{"key":"2025052712182468400_CIT0039","doi-asserted-by":"publisher","first-page":"36427","DOI":"10.1074\/jbc.M110.143263","article-title":"BiP modulates the affinity of its co-chaperone ERj1 for ribosomes","volume":"285","author":"Benedix","year":"2010","journal-title":"J Biol Chem."},{"key":"2025052712182468400_CIT0040","author":"Pig (Sscrofa11.1)","year":"2021"},{"key":"2025052712182468400_CIT0041","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst"},{"key":"2025052712182468400_CIT0042","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell."},{"key":"2025052712182468400_CIT0043","article-title":"UMAP: uniform manifold approximation and projection for dimension reduction","author":"McInnes","year":"2018","journal-title":"arXiv"},{"key":"2025052712182468400_CIT0044","author":"Meehan","year":"2021"},{"key":"2025052712182468400_CIT0045","first-page":"226","article-title":"A density-based algorithm for discovering clusters in large spatial databases with noise","author":"Ester","year":"1996"},{"key":"2025052712182468400_CIT0046","author":"dbscan","year":"2021"},{"key":"2025052712182468400_CIT0047","author":"Gene Ontology Annotations: Cell Cycle","year":"2022"},{"key":"2025052712182468400_CIT0048","author":"trainAutoencoder","year":"2021"},{"key":"2025052712182468400_CIT0049","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"2025052712182468400_CIT0050","doi-asserted-by":"publisher","first-page":"D1057","DOI":"10.1093\/nar\/gku1113","article-title":"The GOA database: gene ontology annotation updates for 2015","volume":"43","author":"Huntley","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2025052712182468400_CIT0051","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2025052712182468400_CIT0052","doi-asserted-by":"publisher","first-page":"D498","DOI":"10.1093\/nar\/gkz1031","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2025052712182468400_CIT0053","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/rssb.12298","article-title":"Multiple testing with the structure-adaptive Benjamini\u2013Hochberg algorithm","volume":"81","author":"Li","year":"2019","journal-title":"J R Stat Soc, B: Stat Methodol"},{"key":"2025052712182468400_CIT0054","article-title":".","year":"2024"},{"key":"2025052712182468400_CIT0055","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1253\/circj.cj-13-0176","article-title":"Regulation of chromatin structure in the cardiovascular system","volume":"77","author":"Rosa-Garrido","year":"2013","journal-title":"Circ J."},{"key":"2025052712182468400_CIT0056","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics."},{"key":"2025052712182468400_CIT0057","doi-asserted-by":"publisher","first-page":"e12710","DOI":"10.15252\/emmm.202012710","article-title":"MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling","volume":"13","author":"Wu","year":"2021","journal-title":"EMBO Mol Med."},{"key":"2025052712182468400_CIT0058","doi-asserted-by":"publisher","first-page":"6166","DOI":"10.1038\/s41467-023-41799-1","article-title":"Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy","volume":"14","author":"Hedaya","year":"2023","journal-title":"Nat Commun."},{"key":"2025052712182468400_CIT0059","doi-asserted-by":"publisher","first-page":"e0232963","DOI":"10.1371\/journal.pone.0232963","article-title":"Identifying the key regulators that promote cell-cycle activity in the hearts of early neonatal pigs after myocardial injury","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One."}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stmcls\/advance-article-pdf\/doi\/10.1093\/stmcls\/sxaf018\/62927829\/sxaf018.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/43\/5\/sxaf018\/62927829\/sxaf018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/43\/5\/sxaf018\/62927829\/sxaf018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:18:36Z","timestamp":1748362716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/doi\/10.1093\/stmcls\/sxaf018\/8113339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,15]]}},"URL":"https:\/\/doi.org\/10.1093\/stmcls\/sxaf018","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,15]]},"article-number":"sxaf018"}}