{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:07:18Z","timestamp":1788898038600,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Republic of Korea","award":["NRF-2021R1A2C1007054"],"award-info":[{"award-number":["NRF-2021R1A2C1007054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mesenchymal stem cells (MSCs) have been widely studied for treating immune-mediated diseases due to their immunomodulatory abilities. Recent studies have shown that priming MSCs with inflammatory cytokines can enhance these functions, yet the optimal priming conditions for canine MSCs remain poorly defined. In this study, we investigated the effects of priming canine adipose tissue-derived MSCs (cAMSCs) with inflammatory cytokines IFN-\u03b3, TNF-\u03b1, and IL-17 at various concentrations (10, 20, and 50\u00a0ng\/mL) to evaluate their immunomodulatory and migratory capacities. Of the 3 cytokines evaluated, only IFN-\u03b3 priming significantly enhanced the expression of immunosuppressive genes IDO and PD-L1, and robustly suppressed T-cell proliferation across all concentrations compared to na\u00efve cAMSCs in both direct co-culture and indirect (conditioned medium) assays. TNF-\u03b1 priming significantly increased HGF expression and promoted cell cycle progression, while IL-17 priming upregulated COX2 and TGF-\u03b2 expression; however, both exhibited limited immunomodulatory effects compared to IFN-\u03b3. In addition, IFN-\u03b3 induced strong expression of adhesion and migration-related genes, including E-CADHERIN, ICAM1, and VCAM1, and promoted cAMSCs migration in a wound healing assay. Despite increasing MHC II, IFN-\u03b3 did not induce CD80, preserving the low immunogenic profile of cAMSCs. These findings support IFN-\u03b3 priming as the most effective strategy to enhance the immunomodulatory and migratory functions of cAMSCs, offering substantial potential for MSC-based therapies in veterinary medicine.<\/jats:p>","DOI":"10.1093\/stmcls\/sxaf044","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:57:11Z","timestamp":1752073031000},"source":"Crossref","is-referenced-by-count":2,"title":["Differential effects of various cytokine priming on T-cell suppression and migration in canine mesenchymal stem cells"],"prefix":"10.1093","volume":"43","author":[{"given":"Chan-Hee","family":"Jo","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 52828,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Gyeongsang National University , Jinju 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