{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:31:33Z","timestamp":1791394293034,"version":"4.3.3"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 AG075573, R00 HL135740, RM1GM42002, R35 CA197442"],"award-info":[{"award-number":["R21 AG075573, R00 HL135740, RM1GM42002, R35 CA197442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Case Comprehensive Cancer Center Support Grant","award":["P30CA043703"],"award-info":[{"award-number":["P30CA043703"]}]},{"name":"Clinical and Translational Science Collaborative of Northern Ohio"},{"name":"National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health","award":["UM1TR004528"],"award-info":[{"award-number":["UM1TR004528"]}]},{"DOI":"10.13039\/100010257","name":"Ohio Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010257","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Valour Foundation, as the Rebecca E. Barchas, MD, University Professor in Translational Psychiatry of Case Western Reserve University"},{"name":"Morley-Mather Chair in Neuropsychiatry of University Hospitals of Cleveland Medical Center, and through the Louis Stokes VA Medical Center resources and facilities"},{"name":"NIDDK Innovative Science Accelerator Program","award":["DK128851"],"award-info":[{"award-number":["DK128851"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hematopoietic aging is characterized by diminished stem cell regenerative capacity and an increased risk of hematologic dysfunction. We previously identified that the prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) regulates hematopoietic stem cell (HSC) activity. Here, we expand on this work and demonstrate that in aged mice: (1) 15-PGDH expression and activity remain conserved in the bone marrow (BM) and spleen, suggesting that it remains a viable therapeutic target in aging; (2) prolonged PGDH inhibition (PGDHi) significantly increases the frequency and number of phenotypic hematopoietic stem and progenitor cells across multiple compartments, with transcriptional changes indicative of enhanced function; (3) PGDHi-treated BM enhances short-term hematopoietic recovery following transplantation, leading to improved peripheral blood output and accelerated multilineage reconstitution; and (4) PGDHi confers a competitive advantage in primary hematopoietic transplantation while mitigating age-associated myeloid bias in secondary transplants. Notably, these effects occur without perturbing steady-state blood production, suggesting that PGDHi enhances hematopoiesis under regenerative conditions while maintaining homeostasis. Our work identifies PGDHi as a translatable intervention to rejuvenate aged HSCs and mitigate hematopoietic decline.<\/jats:p>","DOI":"10.1093\/stmcls\/sxaf047","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:05:07Z","timestamp":1751443507000},"source":"Crossref","is-referenced-by-count":3,"title":["15-PGDH inhibition enhances hematopoietic regeneration during aging"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6183-9483","authenticated-orcid":false,"given":"Rahul","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany 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, Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyannah A","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritisha","family":"Rashmil","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Goshevski","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne N P","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Department of Pharmacology, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A","family":"Pieper","sequence":"additional","affiliation":[{"name":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center , Cleveland, OH io44106,","place":["United States"]},{"name":"Department of Psychiatry, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center , Cleveland, OH io44106,","place":["United States"]},{"name":"Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Department of Neuroscience, Case Western Reserve University , Cleveland, OH io44106,","place":["United States"]},{"name":"Department of Pathology, Case Western Reserve University , Cleveland, OH 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