{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:14:31Z","timestamp":1788448471120,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss 3R Competence Center"},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSK-3_195902, PZ00P3_216225"],"award-info":[{"award-number":["CRSK-3_195902, PZ00P3_216225"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The integrity and function of the blood\u2011brain barrier (BBB) are largely regulated by pericytes. Pericyte deficiency leads to BBB breakdown and neurological dysfunction in major neurological disorders including stroke and Alzheimer\u2019s disease (AD). Transplantation of pericytes derived from induced pluripotent stem cells (iPSC\u2011PC) has been shown to restore the BBB and improve functional recovery in mouse models of stroke and pericyte deficiency. However, the molecular profile and functional properties of iPSC\u2011PC under hypoxic conditions, similar to those found in ischemic and neurodegenerative diseases remain largely unexplored.Methods: We examined iPSC\u2011PC under hypoxia to assess molecular marker expression, proliferation, ability to home to brain vessels, and uptake of amyloid beta (A\u03b2).Results: iPSC\u2011PC under severe hypoxia retain essential functional properties, including key molecular markers, proliferation rates, and the ability to migrate to host brain vessels via function\u2011associated PDGFRB\u2011PDGF\u2011BB signaling. Additionally, we show that iPSC\u2011PC exhibit similar clearance of A\u03b2 neurotoxins from AD mouse brain sections under both normoxic and hypoxic conditions.Conclusions: These findings suggest that iPSC\u2011PC functions are largely resilient to hypoxia, highlighting their potential as a promising cell source for treating ischemic and neurodegenerative disorders.<\/jats:p>","DOI":"10.1093\/stmcls\/sxaf055","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:06Z","timestamp":1753876206000},"source":"Crossref","is-referenced-by-count":8,"title":["Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia"],"prefix":"10.1093","volume":"43","author":[{"given":"Mingzi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Physiology and Neuroscience, University of Southern California , Los Angeles, CA 90033,","place":["United States"]},{"name":"Zilkha Neurogenetic 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