{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:49:02Z","timestamp":1780634942682,"version":"3.54.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502995"],"award-info":[{"award-number":["82502995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572467"],"award-info":[{"award-number":["82572467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Shaanxi Province","award":["2024JC-YBMS-735"],"award-info":[{"award-number":["2024JC-YBMS-735"]}]},{"name":"Key Research and Development Program of Shaanxi Province","award":["2025JC-QYCX-083"],"award-info":[{"award-number":["2025JC-QYCX-083"]}]},{"name":"Key Research and Development Program of Shaanxi Province","award":["2025JC-YBQN-1295"],"award-info":[{"award-number":["2025JC-YBQN-1295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adipose-derived stem cell exosome (ADSC-exo) has been reported to be effective in alleviating organ dysfunction in sepsis, including acute liver injury (ALI). Whether ADSC-exo protects the liver via suppression of vascular endothelial cell (VEC) ferroptosis is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the viability and migration of VECs and their ferroptosis-related indices. To further elucidate this mechanism, we examined the Nrf2\/GPX4 pathway. Cecal ligation and puncture (CLP) was performed to establish a sepsis model to observe the protective effect of ADSC-exo. The death rate and liver tissue injury were observed. We also evaluated inflammation- and ferroptosis-related indices. Next, we examined the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)\/glutathione peroxidase 4 (GPX4) pathway-related molecules to elucidate the underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ADSC-exo reduced cell injury and ferroptosis in VECs. ADSC-exo increased the expression and nuclear translocation of Nrf2. In the CLP-induced sepsis model, ADSC-exo relieved liver injury and reduced the death rate. Further observations showed that ADSC-exo significantly alleviated oxidative stress injury and ferroptosis in liver tissue, while remarkably increasing the expression of Nrf2 and GPX4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate the remarkable ability of ADSC-exo to alleviate sepsis-induced ALI by mitigating endothelial cell ferroptosis, providing evidence for the potential clinical application of ADSC-exo in ALI therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stmcls\/sxaf063","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:03:00Z","timestamp":1758801780000},"source":"Crossref","is-referenced-by-count":3,"title":["Exosomes derived from ADSC suppress endothelial cells ferroptosis and alleviate sepsis acute liver injury via regulation of Keap1\/Nrf2\/GPX4 axis"],"prefix":"10.1093","volume":"44","author":[{"given":"Xianqi","family":"Wang","sequence":"first","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine , Ji\u2019nan, Shandong 250013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Xu","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heliang","family":"Fu","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshou","family":"Liu","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]},{"name":"Emergency Department, Air Force Medical Center, The Fourth Military Medical University , Beijing 100142,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yin","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-6507","authenticated-orcid":false,"given":"Kuo","family":"Shen","sequence":"additional","affiliation":[{"name":"Emergency Department, Xijing Hospital, Fourth Military Medical University , Xi\u2019an, Shanxi 710032,","place":["China"]},{"name":"Air Force Hospital of Western Theater Command , Chengdu, Sichuan 610065,","place":["P.R. 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