{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T05:33:38Z","timestamp":1775108018076,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Qiantang Scholars Fund in Hangzhou City University","award":["210000-581835"],"award-info":[{"award-number":["210000-581835"]}]},{"name":"Zhejiang Province Basic Public Welfare Research Project","award":["LBY24H080001"],"award-info":[{"award-number":["LBY24H080001"]}]},{"name":"Ningbo Natural Science Foundation Project","award":["2024J306"],"award-info":[{"award-number":["2024J306"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely regarded as the most potent curative cell therapy for a range of malignancies, particularly hematologic cancers. However, its clinical application remains significantly constrained by acute graft-versus-host disease (aGVHD), a severe and potentially fatal complication. As such, developing more effective strategies to prevent and manage aGVHD has become an urgent priority in the field. In a groundbreaking study, the team led by Zhan Cheng and Zhu Xiaoyu introduced a novel time-based approach, revealing that the biological rhythm regulating the immune microenvironment can be harnessed to optimize the timing of hematopoietic stem cell infusion. Their findings demonstrate that this chronotherapeutic strategy can significantly reduce the incidence of aGVHD, offering a simple, drug-free, and cost-free innovation to improve outcomes in allo-HSCT.<\/jats:p>","DOI":"10.1093\/stmcls\/sxaf084","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T12:31:25Z","timestamp":1767357085000},"source":"Crossref","is-referenced-by-count":0,"title":["Circadian timing optimizes allo-HSCT to prevent aGVHD: a breakthrough in chrono-immunotherapy"],"prefix":"10.1093","volume":"44","author":[{"given":"Xiaguang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology, the Affiliated Yangming Hospital of Ningbo University , Yuyao, Zhejiang 315400,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hening","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Hangzhou City University , Hangzhou, Zhejiang 310015,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanru","family":"Xia","sequence":"additional","affiliation":[{"name":"School of mathematics and statistics, Donghua University , Shanghai, 201620,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeshan","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University , Hangzhou, Zhejiang 310000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-2877","authenticated-orcid":false,"given":"Shiwei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Hangzhou City University , Hangzhou, Zhejiang 310015,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology, the 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