{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T09:14:32Z","timestamp":1782638072233,"version":"3.54.5"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01EY022051"],"award-info":[{"award-number":["R01EY022051"]}]},{"name":"National Institute of Health","award":["R01EY029778"],"award-info":[{"award-number":["R01EY029778"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glaucoma represents a group of diseases where the unifying theme is the progressive degeneration of retinal ganglion cells (RGCs), causing irreversible vision loss. Mutations in the myocilin (MYOC) gene represent one of the most common genetic factors associated with primary open-angle glaucoma (POAG). However, the mechanism underlying MYOC mutation-associated POAG is poorly understood. Here, using human disease modeling of MYOC mutation (A445V)-dependent POAG, which is usually without ocular hypertension, we have tested a hypothesis that human RGCs (hRGCs) are the target of the mutant protein, making them vulnerable to degenerative changes. Examination of hRGCs generated from MYOCA445V POAG patient-specific induced pluripotent stem cells (iPSCs) revealed that their differentiation is adversely affected, compared to those generated from isogenic control iPSCs. Retinal ganglion cells regulatory and axon growth and guidance gene expression is decreased in patient-specific hRGCs vs isogenic controls. Consequently, the former display immature neurites and their ability to form synapses with the target cells and regenerate are compromised. Furthermore, they display immature networking physiology compared to isogenic controls. The pathological burden of the mutant protein is reflected in their preferential retention in the endoplasmic reticulum (ER) of patient-specific hRGCs, activating the unfolded protein response (UPR) toward mutation-associated developmental phenotype. Furthermore, we demonstrate that REDD1, a stress-induced factor, is a mechanistic link between the MYOCA445V-activated UPR axis and inhibited mTOR signaling, a critical regulator of RGC development and function. Ours is the first demonstration of MYOC mutation-dependent hRGC phenotype and posits a mechanism for hRGC susceptibility toward degeneration independent of ocular hypertension.<\/jats:p>","DOI":"10.1093\/stmcls\/sxag009","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:41:56Z","timestamp":1771418516000},"source":"Crossref","is-referenced-by-count":1,"title":["Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling"],"prefix":"10.1093","volume":"44","author":[{"given":"Subrata Kumar","family":"Shil","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center , Omaha, NE 68198,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Subramani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center , Omaha, NE 68198,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Van Hook","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center , Omaha, NE 68198,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health, University of Nebraska Medical Center , Omaha, NE 68198,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-9381","authenticated-orcid":false,"given":"Iqbal","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, College of Medicine, University of Nebraska Medical Center , Omaha, NE 68198,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"2026031001070622100_sxag009-B1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0161-6420(00)00518-2","article-title":"Natural history of normal-tension glaucoma","volume":"108","author":"Anderson","year":"2001","journal-title":"Ophthalmology."},{"key":"2026031001070622100_sxag009-B2","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/stem.2513","article-title":"Generation of functional human retinal ganglion cells with target specificity from pluripotent stem cells by chemically defined recapitulation of developmental mechanism","volume":"35","author":"Teotia","year":"2017","journal-title":"Stem Cells."},{"key":"2026031001070622100_sxag009-B3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/humu.20634","article-title":"Myocilin allele-specific glaucoma phenotype database","volume":"29","author":"Hewitt","year":"2008","journal-title":"Hum Mutat."},{"key":"2026031001070622100_sxag009-B4","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/hmg\/8.5.899","article-title":"Analysis of myocilin mutations in 1703 glaucoma patients from five different populations","volume":"8","author":"Fingert","year":"1999","journal-title":"Hum Mol Genet."},{"key":"2026031001070622100_sxag009-B5","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1056\/NEJMra0804630","article-title":"Primary open-angle glaucoma","volume":"360","author":"Kwon","year":"2009","journal-title":"N Engl J Med."},{"key":"2026031001070622100_sxag009-B6","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1056\/NEJM199804093381503","article-title":"Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)","volume":"338","author":"Alward","year":"1998","journal-title":"N Engl J Med."},{"key":"2026031001070622100_sxag009-B7","doi-asserted-by":"publisher","first-page":"101188","DOI":"10.1016\/j.preteyeres.2023.101188","article-title":"Myocilin misfolding and glaucoma: a 20-year update","volume":"95","author":"Saccuzzo","year":"2023","journal-title":"Prog Retin Eye Res."},{"key":"2026031001070622100_sxag009-B8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/s0039-6257(02)00353-3","article-title":"Myocilin glaucoma","volume":"47","author":"Fingert","year":"2002","journal-title":"Surv Ophthalmol."},{"key":"2026031001070622100_sxag009-B9","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1038\/s41467-020-19352-1","article-title":"ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load","volume":"11","author":"Kasetti","year":"2020","journal-title":"Nat Commun."},{"key":"2026031001070622100_sxag009-B10","doi-asserted-by":"publisher","first-page":"11903","DOI":"10.1523\/JNEUROSCI.3020-06.2006","article-title":"Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice","volume":"26","author":"Senatorov","year":"2006","journal-title":"J Neurosci."},{"key":"2026031001070622100_sxag009-B11","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.1172\/JCI58183","article-title":"Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma","volume":"121","author":"Zode","year":"2011","journal-title":"J Clin Invest."},{"key":"2026031001070622100_sxag009-B12","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1167\/iovs.07-1339","article-title":"Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma","volume":"49","author":"Zhou","year":"2008","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"2026031001070622100_sxag009-B13","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1086\/338709","article-title":"Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene","volume":"70","author":"Vincent","year":"2002","journal-title":"Am J Hum Genet."},{"key":"2026031001070622100_sxag009-B14","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1093\/hmg\/11.18.2077","article-title":"Founder TIGR\/myocilin mutations for glaucoma in the Quebec population","volume":"11","author":"Faucher","year":"2002","journal-title":"Hum Mol Genet."},{"key":"2026031001070622100_sxag009-B15","first-page":"862","article-title":"Role of MYOC and OPTN sequence variations in Spanish patients with primary open-angle glaucoma","volume":"13","author":"Lopez-Martinez","year":"2007","journal-title":"Mol Vis"},{"key":"2026031001070622100_sxag009-B16","first-page":"284","article-title":"Prevalence of myocilin and optineurin sequence variants in German normal tension glaucoma patients","volume":"11","author":"Weisschuh","year":"2005","journal-title":"Mol Vis."},{"key":"2026031001070622100_sxag009-B17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.20344\/amp.14922","article-title":"MYOC gene sequencing analysis in primary open-angle glaucoma patients from the centre region of Portugal","volume":"34","author":"Silva","year":"2021","journal-title":"Acta Med Port."},{"key":"2026031001070622100_sxag009-B18","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00335-001-2101-3","article-title":"Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development","volume":"13","author":"Brown","year":"2002","journal-title":"Mamm Genome."},{"key":"2026031001070622100_sxag009-B19","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.neuron.2009.01.020","article-title":"Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells","volume":"61","author":"Badea","year":"2009","journal-title":"Neuron."},{"key":"2026031001070622100_sxag009-B20","doi-asserted-by":"publisher","first-page":"6942","DOI":"10.1073\/pnas.0802627105","article-title":"Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2","volume":"105","author":"Mu","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026031001070622100_sxag009-B21","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1523\/JNEUROSCI.16-07-02261.1996","article-title":"Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells","volume":"16","author":"Zhou","year":"1996","journal-title":"J Neurosci."},{"key":"2026031001070622100_sxag009-B22","first-page":"1540","article-title":"Gamma-synuclein as a marker of retinal ganglion cells","volume":"14","author":"Surgucheva","year":"2008","journal-title":"Mol Vis."},{"key":"2026031001070622100_sxag009-B23","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/0306-4522(84)90195-7","article-title":"Thy-1 antigen: a ganglion cell specific marker in rodent retina","volume":"11","author":"Barnstable","year":"1984","journal-title":"Neuroscience."},{"key":"2026031001070622100_sxag009-B24","doi-asserted-by":"publisher","first-page":"1214104","DOI":"10.3389\/fcell.2023.1214104","article-title":"Reproducible generation of human retinal ganglion cells from banked retinal progenitor cells: analysis of target recognition and IGF-1-mediated axon regeneration","volume":"11","author":"Subramani","year":"2023","journal-title":"Front Cell Dev Biol."},{"key":"2026031001070622100_sxag009-B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1759091414562107","article-title":"Connecting the retina to the brain","volume":"6","author":"Erskine","year":"2014","journal-title":"ASN Neuro."},{"key":"2026031001070622100_sxag009-B26","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1523\/JNEUROSCI.09-03-00893.1989","article-title":"Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons","volume":"9","author":"Hoffman","year":"1989","journal-title":"J Neurosci."},{"key":"2026031001070622100_sxag009-B27","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/dneu.20934","article-title":"Multiple transcription factor families regulate axon growth and regeneration","volume":"71","author":"Moore","year":"2011","journal-title":"Dev Neurobiol."},{"key":"2026031001070622100_sxag009-B28","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3389\/fgene.2018.00633","article-title":"Different effect of Sox11 in retinal ganglion cells survival and axon regeneration","volume":"9","author":"Li","year":"2018","journal-title":"Front Genet."},{"key":"2026031001070622100_sxag009-B29","doi-asserted-by":"publisher","first-page":"dev178012","DOI":"10.1242\/dev.178012","article-title":"Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway","volume":"146","author":"Teotia","year":"2019","journal-title":"Development."},{"key":"2026031001070622100_sxag009-B30","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1093\/stmcls\/sxad061","article-title":"Human retinal ganglion cells respond to evolutionarily conserved chemotropic cues for intra retinal guidance and regeneration","volume":"41","author":"Subramani","year":"2023","journal-title":"Stem Cells."},{"key":"2026031001070622100_sxag009-B31","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA."},{"key":"2026031001070622100_sxag009-B32","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"2026031001070622100_sxag009-B33","doi-asserted-by":"publisher","first-page":"203781","DOI":"10.1016\/j.cdev.2022.203781","article-title":"Emerging roles of endoplasmic reticulum proteostasis in brain development","volume":"170","author":"Vasquez","year":"2022","journal-title":"Cells Dev"},{"key":"2026031001070622100_sxag009-B34","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1017\/S0021932025000252","article-title":"Menstrual hygiene practices, determinants, and association with reproductive tract infection in India: a large repeated cross-sectional analysis (2015-2021)","volume":"57","author":"Zode","year":"2025","journal-title":"J Biosoc Sci."},{"key":"2026031001070622100_sxag009-B35","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.tins.2016.04.002","article-title":"Emerging roles for the unfolded protein response in the developing nervous system","volume":"39","author":"Godin","year":"2016","journal-title":"Trends Neurosci."},{"key":"2026031001070622100_sxag009-B36","doi-asserted-by":"publisher","first-page":"5824","DOI":"10.1021\/bi200231x","article-title":"The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder","volume":"50","author":"Burns","year":"2011","journal-title":"Biochemistry."},{"key":"2026031001070622100_sxag009-B37","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1038\/s12276-023-01056-3","article-title":"The stress-responsive protein REDD1 and its pathophysiological functions","volume":"55","author":"Kim","year":"2023","journal-title":"Exp Mol Med."},{"key":"2026031001070622100_sxag009-B38","doi-asserted-by":"publisher","first-page":"3792","DOI":"10.1038\/onc.2011.102","article-title":"TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1","volume":"30","author":"Jin","year":"2011","journal-title":"Oncogene."},{"key":"2026031001070622100_sxag009-B39","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41419-021-04417-w","article-title":"Amino acid deprivation induces AKT activation by inducing GCN2\/ATF4\/REDD1 axis","volume":"12","author":"Jin","year":"2021","journal-title":"Cell Death Dis."},{"key":"2026031001070622100_sxag009-B40","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.bbrc.2008.12.079","article-title":"ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression","volume":"379","author":"Whitney","year":"2009","journal-title":"Biochem Biophys Res Commun."},{"key":"2026031001070622100_sxag009-B41","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1101\/gad.1617608","article-title":"Hypoxia regulates TSC1\/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling","volume":"22","author":"DeYoung","year":"2008","journal-title":"Genes Dev."},{"key":"2026031001070622100_sxag009-B42","doi-asserted-by":"publisher","first-page":"ra68","DOI":"10.1126\/scisignal.2005103","article-title":"REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling","volume":"7","author":"Dennis","year":"2014","journal-title":"Sci Signal."},{"key":"2026031001070622100_sxag009-B43","doi-asserted-by":"publisher","first-page":"794580","DOI":"10.3389\/fimmu.2021.794580","article-title":"Endoplasmic reticulum stress-associated neuronal death and innate immune response in neurological diseases","volume":"12","author":"Shi","year":"2021","journal-title":"Front Immunol."},{"key":"2026031001070622100_sxag009-B44","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.omtn.2023.07.015","article-title":"RGC-specific ATF4 and\/or CHOP deletion rescues glaucomatous neurodegeneration and visual function","volume":"33","author":"Fang","year":"2023","journal-title":"Mol Ther Nucleic Acids."},{"key":"2026031001070622100_sxag009-B45","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3389\/fnins.2014.00423","article-title":"Revealing neuronal function through microelectrode array recordings","volume":"8","author":"Obien","year":"2014","journal-title":"Front Neurosci."},{"key":"2026031001070622100_sxag009-B46","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1016\/j.stemcr.2021.07.001","article-title":"Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro","volume":"16","author":"Mossink","year":"2021","journal-title":"Stem Cell Reports."},{"key":"2026031001070622100_sxag009-B47","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3390\/biology11020316","article-title":"Multielectrode arrays for functional phenotyping of neurons from induced pluripotent stem cell models of neurodevelopmental disorders","volume":"11","author":"McCready","year":"2022","journal-title":"Biology (Basel)"},{"key":"2026031001070622100_sxag009-B48","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.stemcr.2024.06.009","article-title":"Human microglia-derived proinflammatory cytokines facilitate human retinal ganglion cell development and regeneration","volume":"19","author":"Subramani","year":"2024","journal-title":"Stem Cell Reports."},{"key":"2026031001070622100_sxag009-B49","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1167\/iovs.15-17511","article-title":"siRNA-Mediated knockdown of the mTOR inhibitor RTP801 promotes retinal ganglion cell survival and axon elongation by direct and indirect mechanisms","volume":"57","author":"Morgan-Warren","year":"2016","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"2026031001070622100_sxag009-B50","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science."},{"key":"2026031001070622100_sxag009-B51","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1086\/302098","article-title":"Prevalence of mutations in TIGR\/myocilin in patients with adult and juvenile primary open-angle glaucoma","volume":"63","author":"Wiggs","year":"1998","journal-title":"Am J Hum Genet."},{"key":"2026031001070622100_sxag009-B52","doi-asserted-by":"publisher","first-page":"1595121","DOI":"10.3389\/fcell.2025.1595121","article-title":"Protein misfolding and mitochondrial dysfunction in glaucoma","volume":"13","author":"Venkatesan","year":"2025","journal-title":"Front Cell Dev Biol."},{"key":"2026031001070622100_sxag009-B53","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3892\/ijmm.2018.3992","article-title":"Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (review)","volume":"43","author":"Wang","year":"2019","journal-title":"Int J Mol Med."},{"key":"2026031001070622100_sxag009-B54","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/humu.24238","article-title":"Common and rare myocilin variants: predicting glaucoma pathogenicity based on genetics, clinical, and laboratory misfolding data","volume":"42","author":"Scelsi","year":"2021","journal-title":"Hum Mutat."},{"key":"2026031001070622100_sxag009-B55","doi-asserted-by":"publisher","first-page":"7707","DOI":"10.1128\/MCB.21.22.7707-7713.2001","article-title":"Targeted disruption of the myocilin gene (myoc) suggests that human glaucoma-causing mutations are gain of function","volume":"21","author":"Kim","year":"2001","journal-title":"Mol Cell Biol."},{"key":"2026031001070622100_sxag009-B56","doi-asserted-by":"publisher","first-page":"9019","DOI":"10.1128\/MCB.24.20.9019-9025.2004","article-title":"Genetically increasing MYOC expression supports a necessary pathologic role of abnormal proteins in glaucoma","volume":"24","author":"Gould","year":"2004","journal-title":"Mol Cell Biol."},{"key":"2026031001070622100_sxag009-B57","doi-asserted-by":"publisher","first-page":"8427","DOI":"10.1128\/MCB.01127-06","article-title":"Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma","volume":"26","author":"Gould","year":"2006","journal-title":"Mol Cell Biol."},{"key":"2026031001070622100_sxag009-B58","doi-asserted-by":"publisher","first-page":"7639","DOI":"10.1523\/JNEUROSCI.22-17-07639.2002","article-title":"Local and target-derived brain-derived neurotrophic factor exert opposing effects on the dendritic arborization of retinal ganglion cells in vivo","volume":"22","author":"Lom","year":"2002","journal-title":"J Neurosci."},{"key":"2026031001070622100_sxag009-B59","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1167\/iovs.11-8484","article-title":"Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats","volume":"41","author":"Quigley","year":"2000","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"2026031001070622100_sxag009-B60","doi-asserted-by":"publisher","first-page":"875662","DOI":"10.3389\/fphar.2022.875662","article-title":"Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art","volume":"13","author":"Lambuk","year":"2022","journal-title":"Front Pharmacol."},{"key":"2026031001070622100_sxag009-B61","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/379830a0","article-title":"Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system","volume":"379","author":"von Bartheld","year":"1996","journal-title":"Nature."},{"key":"2026031001070622100_sxag009-B62","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.tins.2018.05.009","article-title":"ER proteostasis control of neuronal physiology and synaptic function","volume":"41","author":"Martinez","year":"2018","journal-title":"Trends Neurosci"},{"key":"2026031001070622100_sxag009-B63","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3858\/emm.2009.41.6.049","article-title":"Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells","volume":"41","author":"Cho","year":"2009","journal-title":"Exp Mol Med."},{"key":"2026031001070622100_sxag009-B64","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1002\/jnr.23389","article-title":"Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress","volume":"92","author":"Kawada","year":"2014","journal-title":"J Neurosci Res."},{"key":"2026031001070622100_sxag009-B65","doi-asserted-by":"publisher","first-page":"33324","DOI":"10.1074\/jbc.M110.140699","article-title":"Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis","volume":"285","author":"Frank","year":"2010","journal-title":"J Biol Chem."},{"key":"2026031001070622100_sxag009-B66","doi-asserted-by":"publisher","first-page":"e06963","DOI":"10.7554\/eLife.06963","article-title":"The unfolded protein response is required for dendrite morphogenesis","volume":"4","author":"Wei","year":"2015","journal-title":"Elife."},{"key":"2026031001070622100_sxag009-B67","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.brainres.2016.03.029","article-title":"The UPR and synaptic dysfunction in neurodegeneration","volume":"1648","author":"Freeman","year":"2016","journal-title":"Brain Res."},{"key":"2026031001070622100_sxag009-B68","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1016\/j.cell.2022.08.025","article-title":"ER stress transforms random olfactory receptor choice into axon targeting precision","volume":"185","author":"Shayya","year":"2022","journal-title":"Cell."},{"key":"2026031001070622100_sxag009-B69","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1523\/JNEUROSCI.4011-10.2011","article-title":"RTP801\/REDD1 regulates the timing of cortical neurogenesis and neuron migration","volume":"31","author":"Malagelada","year":"2011","journal-title":"J Neurosci."},{"key":"2026031001070622100_sxag009-B70","doi-asserted-by":"publisher","first-page":"113755","DOI":"10.1016\/j.expneurol.2021.113755","article-title":"RTP801 regulates motor cortex synaptic transmission and learning","volume":"342","author":"P\u00e9rez-Sisqu\u00e9s","year":"2021","journal-title":"Exp Neurol"},{"key":"2026031001070622100_sxag009-B71","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nm.3513","article-title":"REDD1 is essential for stress-induced synaptic loss and depressive behavior","volume":"20","author":"Ota","year":"2014","journal-title":"Nat Med."},{"key":"2026031001070622100_sxag009-B72","doi-asserted-by":"publisher","first-page":"16938","DOI":"10.1523\/JNEUROSCI.1598-10.2010","article-title":"Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA","volume":"30","author":"Galehdar","year":"2010","journal-title":"J Neurosci."},{"key":"2026031001070622100_sxag009-B73","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","article-title":"TUNEL-positive ganglion cells in human primary open-angle glaucoma","volume":"115","author":"Kerrigan","year":"1997","journal-title":"Arch Ophthalmol."},{"key":"2026031001070622100_sxag009-B74","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1093\/brain\/awx088","article-title":"Real-time imaging of single neuronal cell apoptosis in patients with glaucoma","volume":"140","author":"Cordeiro","year":"2017","journal-title":"Brain."},{"key":"2026031001070622100_sxag009-B75","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/70265","article-title":"Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response","volume":"1","author":"Katayama","year":"1999","journal-title":"Nat Cell Biol."},{"key":"2026031001070622100_sxag009-B76","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/jnr.10312","article-title":"Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-golgi stress","volume":"69","author":"Terro","year":"2002","journal-title":"J Neurosci Res."},{"key":"2026031001070622100_sxag009-B77","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/s0092-8674(01)00407-x","article-title":"An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin","volume":"105","author":"Imai","year":"2001","journal-title":"Cell."},{"key":"2026031001070622100_sxag009-B78","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1101\/gad.1640108","article-title":"ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1","volume":"22","author":"Nishitoh","year":"2008","journal-title":"Genes Dev."},{"key":"2026031001070622100_sxag009-B79","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1101\/gad.1673408","article-title":"Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity","volume":"22","author":"Duennwald","year":"2008","journal-title":"Genes Dev."},{"key":"2026031001070622100_sxag009-B80","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrneurol.2017.99","article-title":"ER stress and the unfolded protein response in neurodegeneration","volume":"13","author":"Hetz","year":"2017","journal-title":"Nat Rev Neurol."},{"key":"2026031001070622100_sxag009-B81","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.stem.2014.03.004","article-title":"Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1","volume":"14","author":"Kiskinis","year":"2014","journal-title":"Cell Stem Cell."},{"key":"2026031001070622100_sxag009-B82","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41419-020-2312-8","article-title":"Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling","volume":"11","author":"Ke","year":"2020","journal-title":"Cell Death Dis."},{"key":"2026031001070622100_sxag009-B83","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3390\/biom10081090","article-title":"The UPR in neurodegenerative disease: not just an inside job","volume":"10","author":"van Ziel","year":"2020","journal-title":"Biomolecules."}],"container-title":["Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/stmcls\/advance-article-pdf\/doi\/10.1093\/stmcls\/sxag009\/66993708\/sxag009.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/44\/3\/sxag009\/66993708\/sxag009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stmcls\/article-pdf\/44\/3\/sxag009\/66993708\/sxag009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:07:13Z","timestamp":1773119233000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stmcls\/article\/doi\/10.1093\/stmcls\/sxag009\/8490779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,23]]}},"URL":"https:\/\/doi.org\/10.1093\/stmcls\/sxag009","relation":{},"ISSN":["1066-5099","1549-4918"],"issn-type":[{"value":"1066-5099","type":"print"},{"value":"1549-4918","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,19]]},"article-number":"sxag009"}}