{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:34:19Z","timestamp":1787009659653,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Institutes of Health (NIH)\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["P01 AG066603"],"award-info":[{"award-number":["P01 AG066603"]}]},{"name":"National Institutes of Health (NIH)\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R01 AR079171"],"award-info":[{"award-number":["R01 AR079171"]}]},{"name":"National Institutes of Health (NIH)\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R21 AR078919"],"award-info":[{"award-number":["R21 AR078919"]}]},{"name":"National Institutes of Health (NIH)\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R21AR083544"],"award-info":[{"award-number":["R21AR083544"]}]},{"name":"NIH\/National Institute of Dental and Craniofacial Research","award":["R01 DE031488"],"award-info":[{"award-number":["R01 DE031488"]}]},{"name":"NIH\/National Institute of Dental and Craniofacial Research","award":["R01 DE031028"],"award-info":[{"award-number":["R01 DE031028"]}]},{"DOI":"10.13039\/100001445","name":"Alex\u2019s Lemonade Stand Foundation","doi-asserted-by":"crossref","award":["22-26743"],"award-info":[{"award-number":["22-26743"]}],"id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["DBG-23-1155131-01-IBCD"],"award-info":[{"award-number":["DBG-23-1155131-01-IBCD"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maryland Stem Cell Research Foundation","award":["2021-MSCRFD-5641"],"award-info":[{"award-number":["2021-MSCRFD-5641"]}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["USAMRAA HT9425-24-1-0051"],"award-info":[{"award-number":["USAMRAA HT9425-24-1-0051"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Growth plate injuries in pediatric patients can lead to serious musculoskeletal complications, such as bony bar formation and potential growth arrest. Current clinical treatments have significant limitations, necessitating improved research models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study developed a highly reproducible drill-hole injury model in the mouse distal femur and introduces a quantitative scoring system for assessing bony bar formation. Using micro-computed tomography (\u03bcCT) and histological analyses, we evaluated bone tissue formation over a 42-day period. A 5-point grading system was developed to evaluate bony bar extent, validated through radiological and histological comparisons. We further examine the utility of the model by injuring either transgenic mice with lineage tracing for platelet-derived growth factor receptor alpha (Pdgfra) or beta (Pdgfrb).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>we demonstrate a progressive increase in bone tissue formation over a 42-day period. While not present before injury, both Pdgfra and Pdgfrb reporter+ cells migrate into sites of growth plate injury and participate in bony bar formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This model offers a standardized, reproducible, and validated approach to quantitatively study growth plate injury mechanisms, facilitating the use of transgenic animal models or the development of new therapeutic strategies in pediatric orthopedics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stmcls\/sxag014","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:33:48Z","timestamp":1774182828000},"source":"Crossref","is-referenced-by-count":1,"title":["A mouse growth plate injury model identified contributions of\n                    <i>Pdgfra<\/i>\n                    and\n                    <i>Pdgfrb<\/i>\n                    cellular descendants to bony bar formation"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-9129","authenticated-orcid":false,"given":"Zhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beicheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Archer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University , Baltimore, MD 21205,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-622X","authenticated-orcid":false,"given":"Aaron W","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pathology, 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