{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:01:13Z","timestamp":1790233273445,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"President Foundation of The Fifth Affiliated Hospital, Southern Medical University","award":["YZ2023ZX05"],"award-info":[{"award-number":["YZ2023ZX05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The management of severe diabetic foot ulcers (DFUs) remains a major clinical challenge. Tibial cortex transverse transport (TTT) has emerged as an effective surgical intervention, but its underlying mechanism, particularly concerning stem cell mobilization and signaling pathways, is largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A diabetic DFU model was established in New Zealand white rabbits using Streptozotocin (STZ), followed by TTT surgery. Wound healing was evaluated through photography, H&amp;E, and Masson\u2019s trichrome staining. Angiogenesis was assessed by high-resolution X-ray angiography and immunofluorescence. Bone marrow-derived mesenchymal stem cell (BMSC) mobilization was analyzed via CFU-F assays and flow cytometry. Serum levels of SDF-1\u03b1, CXCR4, VEGF, and Ang2 were measured by enzyme-linked immunosorbent assay and quantitative real-time polymerase chain reaction. The activity of the Wnt\/\u03b2-catenin pathway was determined by Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tibial cortex transverse transport significantly accelerated wound closure and enhanced tissue regeneration, with improved epidermal\/dermal restoration and collagen deposition. Consistently, neovascularization in wounds was markedly promoted. Mechanistically, TTT activated the Wnt\/\u03b2\u2011catenin signaling pathway in BMSCs, which was associated with enhanced BMSC quantity, mobilization, and migration capacity. Inhibition of this pathway attenuated the TTT\u2011induced pro\u2011healing effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tibial cortex transverse transport promotes healing of DFUs primarily by activating the Wnt\/\u03b2-catenin pathway in BMSCs, thereby enhancing their mobilization, homing, and pro-angiogenic capacity. This study reveals a key molecular mechanism underlying TTT\u2019s efficacy and supports its therapeutic potential for refractory Diabetic foot ulcer (DFU).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/stmcls\/sxag049","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:51:25Z","timestamp":1788353485000},"source":"Crossref","is-referenced-by-count":0,"title":["Transverse tibial transport accelerated of diabetic wound healing via enhanced Wnt\/\u03b2-catenin-driven BMSCs mobilization and angiogenesis"],"prefix":"10.1093","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4316-0751","authenticated-orcid":false,"given":"Baoping","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Interventional Vascular Surgery, The Fifth Affiliated Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Surgery, The Fifth Affiliated Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Vascular Surgery, The Fifth Affiliated Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shenzhen Longhua District Central Hospital , Shenzhen 518110, 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