{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:50:14Z","timestamp":1790117414478,"version":"4.0.1"},"reference-count":138,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["#2020\/13467-8"],"award-info":[{"award-number":["#2020\/13467-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Poor sleep quality is closely associated with comorbidities affecting a multitude of organ systems. Among the sleep disorders in the population, there has recently been an increase in the prevalence of obstructive sleep apnea (OSA), which has particularly affected men. The intermittent hypoxia and sleep fragmentation associated with OSA can result in the manifestation or aggravation of a number of pathophysiologic conditions, including the impairment of reproductive function in men and women. In this context, erectile dysfunction (ED) is of particular concern. Other consequences of OSA are changes in the gastrointestinal microbiota, with the resultant dysbiosis having potentially harmful consequences that promote downstream exacerbation of various comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This narrative review aims to explore the potential relationships among ED, gut microbiota, and OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A search of the relevant literature was performed in the PubMed, Embase, Medline, and Web of Science databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sleep is important for regulating the body\u2019s functions, and sleep deprivation can negatively affect health. OSA can damage organic functions, including reproductive function, and can lead to ED. Restoring the microbiota and improving sleep can help to improve sexual function or reverse ED and enhance other associated conditions mediated through the gut-brain axis relationship. Probiotics and prebiotics can be used as supportive strategies in the prevention and treatment of OSA, as they help to reduce systemic inflammation and improve intestinal barrier function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A good diet, a healthy lifestyle, and proper bowel function are essential in controlling depression and several other pathologies. Modulating the gut microbiota through probiotics and prebiotics can provide a viable strategy for developing new therapeutic options in treating many conditions. A better understanding of these a priori unrelated phenomena would foster our understanding of the effects of OSA on human fertility and how changes in gut microbiota may play a role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sxmrev\/qead026","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:34:03Z","timestamp":1686141243000},"page":"76-86","source":"Crossref","is-referenced-by-count":19,"title":["Exploring the potential relationships among obstructive sleep apnea, erectile dysfunction, and gut microbiota: a narrative review"],"prefix":"10.1093","volume":"12","author":[{"given":"Monica Levy","family":"Andersen","sequence":"first","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo, 04024-002 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"Department of Child Health and the Child Health Research Institute, University of Missouri School of Medicine , Columbia, MO 65212 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Natan","family":"Pires","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo, 04024-002 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo, 04024-002 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"2026041420271716600_ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neures.2017.04.017","article-title":"Sleep in vertebrate and invertebrate animals, and insights into the function and evolution of sleep","volume":"118","author":"Miyazaki","year":"2017","journal-title":"Neurosci Res"},{"issue":"6","key":"2026041420271716600_ref2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.5665\/sleep.1846","article-title":"Sleep: a health imperative","volume":"35","author":"Luyster","year":"2012","journal-title":"Sleep"},{"issue":"6","key":"2026041420271716600_ref3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/1559827614544437","article-title":"The bidirectional relationship between exercise and sleep: implications for exercise adherence and sleep improvement","volume":"8","author":"Kline","year":"2014","journal-title":"Am J Lifestyle Med"},{"issue":"3","key":"2026041420271716600_ref4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1590\/S0001-37652009000300016","article-title":"Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. 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