{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:50:18Z","timestamp":1792183818198,"version":"4.4.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018430","name":"IEO-CCM Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018430","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Considering the increasing women\u2019s awareness of health promotion and disease prevention programs, mutation carriers are inevitably asked to face important decisions concerning the possibility of undergoing prophylactic mastectomy. Risk-reducing mastectomy (RRM) has become increasingly more common, although it has a significant impact on women\u2019s quality of life and sexual well-being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The systematic review aims to evaluate the impact of RRM on the sexuality of women with breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>According to Cochrane Collaboration guidelines and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement, the study quantified the effects of frontline work on the mental health of healthcare workers. This review followed the PRISMA guidelines. Three databases were systematically searched from inception to December 2022. The expression (\u201csexuality\u201d OR \u201csexual\u201d OR \u201csex\u201d) AND (\u201cprophylactic mastectomy\u201d OR \u201crisk-reducing mastectomy\u201d) was searched in PubMed, Ovid Medline, and Embase. Twenty-two articles published in English until 2022 were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two studies investigated sexual experience after risk-reducing surgeries as a single outcome, while other studies analyzed the relationship between sexuality and psychosocial outcomes, risk perception, and satisfaction. In all of the included studies, significant findings in sexual dysfunction were found. The most reported problems were related to sexual satisfaction and attractiveness, body image, and loss of femininity. Last, women reported changes in the relationship with their partners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RRM has a major impact on body image that affects sexual functioning and quality of life. These implications must be considered during treatment selection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sxmrev\/qead054","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T17:41:41Z","timestamp":1701711701000},"page":"164-177","source":"Crossref","is-referenced-by-count":15,"title":["The impact of prophylactic mastectomy on sexual well-being: a systematic review"],"prefix":"10.1093","volume":"12","author":[{"given":"Ludovica","family":"Scotto","sequence":"first","affiliation":[{"name":"Applied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS , Via Ripamonti 435, 20141, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Francesca Maria","family":"Pizzoli","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato-Oncology, University of Milan , Via Festa del Perdono 7, 20122 Milan , Italy"},{"name":"Facolt\u00e0 di Psicologia, Universit\u00e0 Cattolica del Sacro Cuore , Largo A. Gemelli 1, 20123 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Marzorati","sequence":"additional","affiliation":[{"name":"Applied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS , Via Ripamonti 435, 20141, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketti","family":"Mazzocco","sequence":"additional","affiliation":[{"name":"Applied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS , Via Ripamonti 435, 20141, Milan , Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan , Via Festa del Perdono 7, 20122 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grabriella","family":"Pravettoni","sequence":"additional","affiliation":[{"name":"Applied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS , Via Ripamonti 435, 20141, Milan , Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan , Via Festa del Perdono 7, 20122 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"2024040211595872500_ref1","volume-title":"Associazione Italiana Oncologia Medica. 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