{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:17:38Z","timestamp":1764569858166},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Living kidney donations (LKDs) face a persistent demand for patients with end-stage renal disease, emphasizing the importance of LKDs\u2019 growth and success. Although living kidney donors generally exhibit excellent survival rates, little research has explored the development of long-term sexual dysfunction following LKD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to analyze differences in 5-year sexual dysfunction outcomes between male and female living kidney donors, utilizing the TriNetX database, a federated network of electronic medical records from multiple U.S. healthcare organizations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A propensity score\u2013matched cohort study compared 45-year sexual dysfunction outcomes in adult male and female living kidney donors from December 2013 to December 2022. Cohorts were matched on age; sex; race and ethnicity; diabetes, cardiovascular, genitourinary, and psychiatric comorbidities; lifestyle-related factors; and medications that may impact normal sexual functioning. Primary outcomes included hazard ratio (HR) for decreased libido, sexual dysfunction (composite of male erectile dysfunction, ejaculatory disorders, vaginismus\/dyspareunia, infertility, orgasmic disorders, arousal\/desire disorders), and sexually transmitted diseases. Secondary outcomes assessed sex counseling and interpersonal relationship issues with spouses or partners.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The matched cohorts included 2315 patients each (male, female), and the mean age was 42.3\u2009\u00b1\u200912.5\u00a0years. At 5 years, male donors had a significantly higher HR for sexual dysfunction (HR, 3.768; 95% confidence interval, 1.929-7.358). Erectile dysfunction occurred in 1% of male patients, while vaginismus\/dyspareunia affected &amp;lt;1% of female patients. Other sexual disorders, decreased libido, sexually transmitted diseases, and incidences of sexual and interspousal counseling were not significantly different.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Male living kidney donors faced a higher risk of developing sexual dysfunction 5 years after donation. While LKD remains a safe and viable alternative, clinicians and donors should be mindful of the potential association with sexual dysfunction postdonation. Further research may enhance support for the well-being of living kidney donors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeae003","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T22:38:43Z","timestamp":1708123123000},"page":"183-191","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of sexual dysfunction development among male and female living kidney donors"],"prefix":"10.1093","volume":"12","author":[{"given":"John C","family":"Johnson","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine , Department of Surgery, , 301 University Boulevard, Galveston, TX 77555-0655 , United States"},{"name":"University of Texas Medical Branch , Department of Surgery, , 301 University Boulevard, Galveston, TX 77555-0655 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Venna","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine , Department of Surgery, , 301 University Boulevard, Galveston, TX 77555-0655 , United States"},{"name":"University of Texas Medical Branch , Department of Surgery, , 301 University Boulevard, Galveston, TX 77555-0655 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laith","family":"Alzweri","sequence":"additional","affiliation":[{"name":"John Sealy School of Medicine , Department of Surgery, , 301 University Boulevard, Galveston, TX 77555-0655 , United States"},{"name":"University of Texas Medical Branch , Department of Surgery, , 301 University Boulevard, Galveston, TX 77555-0655 , United States"},{"name":"Division of Urology , Department of Surgery, , Galveston, TX 77555-0655 , United States"},{"name":"University of Texas Medical Branch , Department of Surgery, , Galveston, TX 77555-0655 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"issue":"4","key":"2024040212021127800_ref1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0272-6386(03)00826-6","article-title":"Proteinuria and other markers of chronic kidney disease: a position statement of the National Kidney Foundation (NKF) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","volume":"42","author":"Eknoyan","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"2024040212021127800_ref2","article-title":"Impact of the COVID-19 pandemic on organ donation from deceased donors in the United States","volume":"7","author":"Zhu","year":"2021","journal-title":"J Alcohol Drug Abuse Subst Depend"},{"issue":"2","key":"2024040212021127800_ref3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/TP.0000000000004464","article-title":"Achieving equity in organ transplantation: recommendations for action based on the National Academies of sciences, engineering, and medicine report","volume":"107","author":"Dageforde","year":"2023","journal-title":"Transplantation"},{"issue":"4","key":"2024040212021127800_ref4","doi-asserted-by":"crossref","first-page":"e12182","DOI":"10.5812\/numonthly.12182","article-title":"Does kidney transplantation with deceased or living donor affect graft survival?","volume":"6","author":"Nemati","year":"2014","journal-title":"Nephro Urol Mon"},{"issue":"1","key":"2024040212021127800_ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12939-020-01200-9","article-title":"Living or deceased-donor kidney transplant: the role of psycho-socioeconomic factors and outcomes associated with each type of transplant","volume":"19","author":"Basiri","year":"2020","journal-title":"Int J Equity Health"},{"issue":"3","key":"2024040212021127800_ref6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1600-6143.2010.03424.x","article-title":"The long-term quality of life of living kidney donors: a multicenter cohort study","volume":"11","author":"Clemens","year":"2011","journal-title":"Am J Transplant"},{"issue":"5","key":"2024040212021127800_ref7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/00007890-199903150-00013","article-title":"Long-term follow-up of living kidney donors: quality of life after donation","volume":"67","author":"Johnson","year":"1999","journal-title":"Transplantation"},{"issue":"6","key":"2024040212021127800_ref8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1399-0012.2009.01196.x","article-title":"Psychosocial evaluation of Chinese living related kidney donors","volume":"24","author":"Zhao","year":"2010","journal-title":"Clin Transpl"},{"issue":"12","key":"2024040212021127800_ref9","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1111\/j.1600-6143.2006.01567.x","article-title":"Psychosocial health of living kidney donors: a systematic review","volume":"6","author":"Clemens","year":"2006","journal-title":"Am J Transplant"},{"issue":"11","key":"2024040212021127800_ref10","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1111\/ajt.12906","article-title":"Emotional well-being of living kidney donors: findings from the RELIVE study","volume":"14","author":"Jowsey","year":"2014","journal-title":"Am J Transplant"},{"issue":"1","key":"2024040212021127800_ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.transproceed.2010.12.028","article-title":"Depression and anxiety in living kidney donation: evaluation of donors and recipients","volume":"43","author":"Lopes","year":"2011","journal-title":"Transplant Proc"},{"issue":"2","key":"2024040212021127800_ref12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/152692480901900206","article-title":"Psychiatric disorders: are they an absolute contraindication to living donation?","volume":"19","author":"Rowley","year":"2009","journal-title":"Prog Transpl"},{"issue":"2","key":"2024040212021127800_ref13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4103\/1319-2442.256848","article-title":"Short- and long-term follow-up of living kidney donors","volume":"30","author":"Abdellaoui","year":"2019","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"4","key":"2024040212021127800_ref14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.7326\/M17-1235","article-title":"Mid- and long-term health risks in living kidney donors: a systematic review and meta-analysis","volume":"168","author":"O\u2019Keeffe","year":"2018","journal-title":"Ann Intern Med"},{"issue":"10","key":"2024040212021127800_ref15","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/sj.ki.5001819","article-title":"Proteinuria and reduced kidney function in living kidney donors: a systematic review, meta-analysis, and meta-regression","volume":"70","author":"Garg","year":"2006","journal-title":"Kidney Int"},{"issue":"6","key":"2024040212021127800_ref16","doi-asserted-by":"crossref","first-page":"537-544","DOI":"10.1001\/jama.281.6.537","article-title":"Sexual dysfunction in the United States: prevalence and predictors","volume":"281","author":"Laumann","year":"1999","journal-title":"JAMA"},{"issue":"2","key":"2024040212021127800_ref17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.maturitas.2009.04.002","article-title":"Epidemiology of female sexual dysfunction","volume":"63","author":"Palacios","year":"2009","journal-title":"Maturitas"},{"key":"2024040212021127800_ref18","doi-asserted-by":"crossref","first-page":"2054358118760833","DOI":"10.1177\/2054358118760833","article-title":"Validation of living donor nephrectomy codes","volume":"5","author":"Lam","year":"2018","journal-title":"Can J Kidney Health Dis"},{"issue":"2","key":"2024040212021127800_ref19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.18773\/austprescr.2013.021","article-title":"Drug-induced sexual dysfunction in men and women","volume":"36","author":"Conaglen","year":"2013","journal-title":"Aust Prescr"},{"issue":"6","key":"2024040212021127800_ref20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00345-006-0136-5","article-title":"Adverse effects of drug therapies on male and female sexual function","volume":"24","author":"Stadler","year":"2006","journal-title":"World J Urol"},{"issue":"1","key":"2024040212021127800_ref21","doi-asserted-by":"crossref","first-page":"c83","DOI":"10.1159\/000324758","article-title":"Survival analysis I: the Kaplan-Meier method","volume":"119","author":"Stel","year":"2011","journal-title":"Nephron Clin Pract"},{"issue":"1","key":"2024040212021127800_ref22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5152\/tud.2019.19169","article-title":"Informing patients about the negative effect of nephrectomy on sexual function","volume":"46","author":"Christiansen","year":"2020","journal-title":"Turk J Urol"},{"issue":"3 Pt B","key":"2024040212021127800_ref23","article-title":"Does radical nephrectomy increase the risk of erectile dysfunction compared with partial nephrectomy? A cohort analysis","volume":"111","author":"Kopp","year":"2013","journal-title":"BJU Int"},{"key":"2024040212021127800_ref24","doi-asserted-by":"crossref","first-page":"205435811985771","DOI":"10.1177\/2054358119857718","article-title":"Perioperative complications during living donor nephrectomy: results from a multicenter cohort study","volume":"6","author":"Garcia-Ochoa","year":"2019","journal-title":"Can J Kidney Health Dis"},{"key":"2024040212021127800_ref25","first-page":"9326975","article-title":"Nerve surgery to treat intractable genitofemoral neuropathic pain following laparoscopic live kidney donation","volume":"2018","author":"Ramdhani","year":"2018","journal-title":"Case Rep Transplant"},{"issue":"9","key":"2024040212021127800_ref26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11906-016-0676-z","article-title":"Renal afferents","volume":"18","author":"Frame","year":"2016","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"2024040212021127800_ref27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.15424\/bioelectronmed.2015.00003","article-title":"Impact of bioelectronic medicine on the neural regulation of pelvic visceral function","volume":"2","author":"de Groat","year":"2015","journal-title":"Bioelectron Med"},{"issue":"3","key":"2024040212021127800_ref28","first-page":"206","article-title":"Age-related changes in the innervation of the prostate gland: implications for prostate cancer initiation and progression","volume":"9","author":"White","year":"2013","journal-title":"Organ"},{"key":"2024040212021127800_ref29","first-page":"647","volume-title":"Tubbs RS, Rizk E, Shoja MM, Loukas M, Barbaro N, Spinner RJ, eds. Nerves and Nerve Injuries. Vol. 1: History, Anatomy, Imaging, and Diagnostics","author":"Tubbs","year":"2015"},{"issue":"8","key":"2024040212021127800_ref30","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00276-010-0677-6","article-title":"Quantitative anatomical study of male pelvic autonomic plexus and its clinical potential in rectal resection","volume":"32","author":"He","year":"2010","journal-title":"Surg Radiol Anat"},{"issue":"2","key":"2024040212021127800_ref31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.urology.2010.03.079","article-title":"Prevalence of erectile dysfunction in living donors before and after nephrectomy in China","volume":"76","author":"Guo","year":"2010","journal-title":"Urology"},{"issue":"2","key":"2024040212021127800_ref32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ekir.2021.11.003","article-title":"Female reproductive and gynecologic considerations in chronic kidney disease: adolescence and young adulthood","volume":"7","author":"Chang","year":"2021","journal-title":"Kidney Int Rep"},{"issue":"10","key":"2024040212021127800_ref33","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1111\/ajt.15350","article-title":"Chronic pain following laparoscopic living-donor nephrectomy: prevalence and impact on quality of life","volume":"19","author":"Bruintjes","year":"2019","journal-title":"Am J Transplant"},{"issue":"2","key":"2024040212021127800_ref34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/pm\/pnac117","article-title":"Sexual functioning among adults with chronic pain: prevalence and association with pain-related outcomes","volume":"24","author":"Flegge","year":"2023","journal-title":"Pain Med"},{"issue":"2","key":"2024040212021127800_ref35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00002508-200106000-00006","article-title":"Sexual difficulties of chronic pain patients","volume":"17","author":"Ambler","year":"2001","journal-title":"Clin J Pain"},{"issue":"6","key":"2024040212021127800_ref36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ejpain.2004.12.008","article-title":"Sexual dysfunction and chronic pain: the role of psychological variables and impact on quality of life","volume":"9","author":"Kwan","year":"2005","journal-title":"Eur J Pain"},{"issue":"9","key":"2024040212021127800_ref37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/09638289809166089","article-title":"Sexuality and sexual adjustment of patients with chronic pain","volume":"20","author":"Monga","year":"1998","journal-title":"Disabil Rehabil"},{"issue":"9","key":"2024040212021127800_ref38","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.jsxm.2016.07.003","article-title":"Opioids increase sexual dysfunction in patients with non-cancer pain","volume":"13","author":"Ajo","year":"2016","journal-title":"J Sex Med"},{"issue":"6","key":"2024040212021127800_ref39","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/pm\/pny122","article-title":"Chronic pain, opioid therapy, sexual desire, and satisfaction in sexual life: a population-based survey","volume":"20","author":"Birke","year":"2019","journal-title":"Pain Med"},{"issue":"1","key":"2024040212021127800_ref40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.2013.460","article-title":"Long-term risks for kidney donors","volume":"86","author":"Mj\u00f8en","year":"2014","journal-title":"Kidney Int"},{"issue":"4","key":"2024040212021127800_ref41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1432-2277.2012.01439.x","article-title":"Very long-term follow-up of living kidney donors: living kidney donors in the very long term","volume":"25","author":"Fournier","year":"2012","journal-title":"Transpl Int"},{"issue":"11","key":"2024040212021127800_ref42","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1111\/j.1600-6143.2009.02795.x","article-title":"How do living kidney donors develop end-stage renal disease?","volume":"9","author":"Kido","year":"2009","journal-title":"Am J Transplant"},{"issue":"3","key":"2024040212021127800_ref43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.7326\/0003-4819-145-3-200608010-00006","article-title":"Meta-analysis: risk for hypertension in living kidney donors","volume":"145","author":"Boudville","year":"2006","journal-title":"Ann Intern Med"},{"issue":"12","key":"2024040212021127800_ref44","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1097\/01.tp.0000250728.73268.e3","article-title":"Incidence of end-stage renal disease among live kidney donors","volume":"82","author":"Fehrman-Ekholm","year":"2006","journal-title":"Transplantation"},{"issue":"1","key":"2024040212021127800_ref45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12882-023-03208-z","article-title":"Long-term end-stage renal disease risks after living kidney donation: a systematic review and meta-analysis","volume":"24","author":"Park","year":"2023","journal-title":"BMC Nephrol"},{"issue":"6","key":"2024040212021127800_ref46","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1001\/jama.2013.285141","article-title":"Risk of end-stage renal disease following live kidney donation","volume":"311","author":"Muzaale","year":"2014","journal-title":"JAMA"},{"issue":"8","key":"2024040212021127800_ref47","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016490","article-title":"Lifetime risks of kidney donation: a medical decision analysis","volume":"7","author":"Kiberd","year":"2017","journal-title":"BMJ Open"},{"issue":"3","key":"2024040212021127800_ref48","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.ijir.3901527","article-title":"Erectile dysfunction and hypertension","volume":"19","author":"Kloner","year":"2007","journal-title":"Int J Impot Res"},{"issue":"10","key":"2024040212021127800_ref49","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000000939","article-title":"Blood pressure and living kidney donors: a clinical perspective","volume":"5","author":"Rastogi","year":"2019","journal-title":"Transplant Direct"},{"issue":"1","key":"2024040212021127800_ref50","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-228","article-title":"Feeling well and talking about sex: psycho-social predictors of sexual functioning after cancer","volume":"14","author":"Perz","year":"2014","journal-title":"BMC Cancer"},{"issue":"4","key":"2024040212021127800_ref51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/NCC.0b013e31819b5a93","article-title":"Changes in sexuality and intimacy after the diagnosis and treatment of cancer: the experience of partners in a sexual relationship with a person with cancer","volume":"32","author":"Hawkins","year":"2009","journal-title":"Cancer Nurs"},{"issue":"Supplement_1","key":"2024040212021127800_ref52","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.jsxm.2016.11.169","article-title":"The comparison of post-operative erectile function after radical nephrectomy and partial nephrectomy","volume":"14","author":"Chiba","year":"2017","journal-title":"J Sex Med"},{"issue":"10","key":"2024040212021127800_ref53","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/j.1600-6143.2007.01932.x","article-title":"The medical evaluation of living kidney donors: a survey of US transplant centers","volume":"7","author":"Mandelbrot","year":"2007","journal-title":"Am J Transplant"}],"container-title":["Sexual Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/smr\/article-pdf\/12\/2\/183\/57133233\/qeae003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/smr\/article-pdf\/12\/2\/183\/57133233\/qeae003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T14:07:16Z","timestamp":1712066836000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/smr\/article\/12\/2\/183\/7606442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,12]]},"published-print":{"date-parts":[[2024,3,26]]}},"URL":"https:\/\/doi.org\/10.1093\/sxmrev\/qeae003","relation":{},"ISSN":["2050-0513","2050-0521"],"issn-type":[{"value":"2050-0513","type":"print"},{"value":"2050-0521","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,2,12]]}}}