{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T12:28:50Z","timestamp":1744979330997,"version":"3.37.3"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Deputy of Research of Tabriz University of Medical Sciences","award":["72832"],"award-info":[{"award-number":["72832"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Iontophoresis therapy (IPT) is a noninvasive technique that uses electrical impulses to deliver charged molecules into the skin for controlled and targeted drug delivery. IPT has been explored as a noninvasive treatment option for Peyronie\u2019s disease (PD), but the current literature in this regard is still scarce.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to systematically review the current literature on the application of IPT in the management of PD to provide a comprehensive evaluation and holistic outlook on the subject.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>A comprehensive search strategy was implemented in the following databases to retrieve research articles: PubMed (MEDLINE), Scopus, and Web of Science. Google Scholar was also manually searched. The search results were imported into Rayyan reference management for assessment based on the predefined inclusion criteria. The quality of the articles was evaluated by the proper JBI checklist (ie, per the study design), and the JBI grades of recommendation were used for grading the evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A systematic search yielded 451 publications, 11 of which met the criteria to be included in this systematic review. The results demonstrated that IPT, usually with verapamil and dexamethasone, has shown promising results in treating PD. These methods can reduce pain, plaque size, and penile curvature while improving sexual function and quality of life with no serious adverse events. However, most studies had moderate to low quality, indicating a weak recommendation for a certain health management strategy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Based on the extant literature, there is currently insufficient evidence to support the use of IPT for the management of PD. Placing it in the forefront of research can facilitate the management choices for PD even further, given its therapeutic potential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeae058","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T23:05:26Z","timestamp":1724713526000},"page":"41-51","source":"Crossref","is-referenced-by-count":0,"title":["Investigating iontophoresis as a therapeutic approach for Peyronie\u2019s disease: a systematic review"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6200-1728","authenticated-orcid":false,"given":"Sahand","family":"Eslami","sequence":"first","affiliation":[{"name":"Research Center for Evidence-Based Medicine , Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, , Tabriz ,","place":["Iran"]},{"name":"Tabriz University of Medical Sciences , Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, , Tabriz ,","place":["Iran"]},{"name":"Immunology Research Center, Tabriz University of Medical Sciences , Tabriz ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-7693","authenticated-orcid":false,"given":"Fateme","family":"Tahmasbi","sequence":"additional","affiliation":[{"name":"Research Center for Evidence-Based Medicine , Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, , Tabriz ,","place":["Iran"]},{"name":"Tabriz University of Medical Sciences , Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, , Tabriz ,","place":["Iran"]},{"name":"Social Determinants of Health Research Center , Health Management and Safety Promotion Research Institute, , Tabriz ,","place":["Iran"]},{"name":"Tabriz University of Medical Sciences , Health Management and Safety Promotion Research Institute, , Tabriz ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8020-2697","authenticated-orcid":false,"given":"Alireza","family":"Rahimi-Mamaghani","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit of Tabriz Valiasr Hospital, University of Medical Sciences , Tabriz ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-5631","authenticated-orcid":false,"given":"Sarvin","family":"Sanaie","sequence":"additional","affiliation":[{"name":"Research Center for Integrative Medicine in Aging , Aging Research Institute, , Tabriz ,","place":["Iran"]},{"name":"Tabriz University of Medical Sciences , Aging Research Institute, , Tabriz ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-3059","authenticated-orcid":false,"given":"Carlo","family":"Bettocchi","sequence":"additional","affiliation":[{"name":"Department of Andrology and Male Genitalia Reconstructive Surgery, University of Foggia , Foggia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-2152","authenticated-orcid":false,"given":"Omid","family":"Sedigh","sequence":"additional","affiliation":[{"name":"Urology and Reconstructive Andrology Department, Humanitas Gradenigo Hospital , Torino, 10125410158 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-8819","authenticated-orcid":false,"given":"Farzin","family":"Soleimanzadeh","sequence":"additional","affiliation":[{"name":"Research Center for Evidence-Based Medicine , Iranian EBM Centre: A JBI Centre of 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