{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:24:19Z","timestamp":1790036659940,"version":"4.0.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The use of hyaluronic acid as a nonsurgical treatment for various conditions within urology has been of great interest in recent literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In this study, we aimed to provide an updated review and analysis of the current state of hyaluronic acid use in urology, characterize its adverse effects, and briefly discuss future directions of research for hyaluronic acid in urology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PubMed searches were run utilizing multiple terms, including \u201chyaluronic acid,\u201d \u201cpenile,\u201d \u201caugmentation,\u201d \u201cPeyronie disease,\u201d \u201cpremature ejaculation,\u201d and \u201ccosmetic urology,\u201d among other related iterations. Relevant data extracted included International Index of Erectile Function score, intravaginal ejaculatory latency, glans circumference, penile girth, and plaque size. We also included studies which reported on complications of hyaluronic acid injections. Aggregated analysis was performed on studies with complete pre and post injection data at time closest to 6\u00a0months postinjection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 33 studies met our inclusion criteria. Studies had marked heterogeneity in design, but most reported positive results. A total of 16 studies were included in our analysis. Intravaginal ejaculatory latency, penile girth, glans circumference, and International Index of Erectile Function were all increased on a fixed-effects model. Reduction in plaque size was not significant (P = .069). Complications were rare.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Literature on hyaluronic acid for urologic issues demonstrates promising results; however, the quality of studies was variable. Our analysis of these studies largely corroborates these findings; however, the results are limited by the data available. Hyaluronic acid may be promising, but we highly implore standardization of study regimens in randomized controlled trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeae060","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:10:20Z","timestamp":1725610220000},"page":"52-61","source":"Crossref","is-referenced-by-count":7,"title":["Hyaluronic acid and urology: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"13","author":[{"given":"Bradley J","family":"Roth","sequence":"first","affiliation":[{"name":"University of California, Irvine, School of Medicine , Irvine, CA 92617,","place":["United States"]},{"name":"Department of Urology, University of California , Irvine, Irvine, CA 92868,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-1364","authenticated-orcid":false,"given":"Muhammed A M","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Urology, University of California , Irvine, Irvine, CA 92868,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Urology, University of California , Irvine, Irvine, CA 92868,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Abou Chawareb","sequence":"additional","affiliation":[{"name":"Department of Urology, University of California , Irvine, Irvine, CA 92868,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Banton","sequence":"additional","affiliation":[{"name":"NYIT College of Osteopathic Medicine\u2013Arkansas , Jonesboro, AR 72401,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean Sung Hun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Urology, Sewum Prosthetic Urology , Seoul,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E","family":"Perito","sequence":"additional","affiliation":[{"name":"Perito Urology, Coral Cables , FL 33146,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faysal A","family":"Yafi","sequence":"additional","affiliation":[{"name":"Department of Urology, University of California , Irvine, Irvine, CA 92868,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Raheem","sequence":"additional","affiliation":[{"name":"Department of Urology, Cleveland Clinic Abu Dhabi , Abu Dhabi,","place":["United Arab 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