{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:06:28Z","timestamp":1788815188356,"version":"build-2803163510"},"reference-count":111,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL166617"],"award-info":[{"award-number":["HL166617"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/13467-8"],"award-info":[{"award-number":["2020\/13467-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This review explores the interplay between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction (ED), 2 conditions that significantly impact men\u2019s health. COMISA, a recently recognized condition characterized by the coexistence of insomnia and obstructive sleep apnea, has been shown to disrupt sleep architecture and cause intermittent hypoxia. These disturbances are increasingly linked to the exacerbation of ED, a prevalent issue among men. Understanding the connection between COMISA and ED is crucial for developing integrated treatment approaches that address both sleep and sexual health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aim to explore the epidemiological, physiological, and potential therapeutic intersections of COMISA and ED. This review sets out to develop a better understanding of the relationship between these conditions and to emphasize the need for an integrated diagnostic and therapeutic approach that addresses both sleep and sexual health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Through a comprehensive analysis, including a detailed examination of extant studies, we address the hormonal imbalances and alterations in neural pathways that collectively contribute to the complex pathophysiology of ED and how these are particularly susceptible to the concurrent presence of COMISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our analysis indicates that disruptions in sleep architecture and intermittent hypoxia associated with COMISA can exacerbate ED. Hormonal imbalances, endothelial dysfunction, autonomic imbalance, and increased inflammation and oxidative stress are key mechanisms through which COMISA influences ED. These factors collectively impair vascular health, reduce testosterone levels, disrupt neural control of erections, and contribute to the severity of ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review underscores the necessity for an integrated approach to diagnosis and therapy that considers both sleep and sexual health to improve overall outcomes. These insights should foster a deeper understanding of the relationship between COMISA and ED, encourage further research in this area, and potentially lead to the development of innovative treatment strategies to manage these closely intertwined health concerns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeae068","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T07:14:26Z","timestamp":1727507666000},"page":"105-115","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the link between comorbid insomnia and sleep apnea (COMISA) and erectile dysfunction: implications for male sexual health"],"prefix":"10.1093","volume":"13","author":[{"given":"Monica Levy","family":"Andersen","sequence":"first","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo (UNIFESP) , S\u00e3o Paulo, 04024-002 ,","place":["Brazil"]},{"name":"Instituto do Sono , S\u00e3o Paulo, 04020-060 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"Joan C. Edwards School of Medicine, Marshall University , Huntington, WV 25701 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo (UNIFESP) , S\u00e3o Paulo, 04024-002 ,","place":["Brazil"]},{"name":"Instituto do Sono , S\u00e3o Paulo, 04020-060 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"issue":"4","key":"2026041420271621300_ref1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.sleep.2009.10.002","article-title":"Arousal threshold determination in 1862: Kohlsch\u00fctter's measurements on the firmness of sleep","volume":"11","author":"Basner","year":"2010","journal-title":"Sleep Med"},{"issue":"6","key":"2026041420271621300_ref2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.sleh.2018.09.008","article-title":"The sanctuary of sleep","volume":"4","author":"Kryger","year":"2018","journal-title":"Sleep Health."},{"issue":"1","key":"2026041420271621300_ref3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.5665\/sleep.3298","article-title":"Sleep health: can we define it? 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