{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:38:14Z","timestamp":1791999494348,"version":"4.4.0"},"reference-count":335,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n There is no ideal treatment for Peyronie\u2019s Disease (PD) since every patient has different needs with varying perceived risks versus benefits of individual treatment options, coupled with the degree of impact relating to PD on sexual function and beyond.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n The 5th International Consultation on Sexual Medicine (ICSM) guideline on PD provides an update to the previous ICSM with an aim to provide a clinical framework and best-evidenced consensus recommendations to assist clinicians in managing PD.<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n Available literature was reviewed, and a modified Delphi consensus was undertaken by leading sexual medicine experts to achieve a set of Quality of Evidence and strength of recommendations. This guideline was developed as an authoritative best-evidenced consensus incorporating state-of-the-art knowledge and contemporary literature.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of thirty-one recommendations were made on PD guidelines. New updates to the 4th ICSM on PD have been made in definition, pathophysiology, and treatment strategies. The presence of penile pain with erection could occur in the chronic phase due to torque or stretch on the penile scar and surrounding tissue. Oral therapy works best during the acute phase and should be provided concurrently with other treatment modalities. Penile traction therapy can reduce penile deformity as monotherapy or may be offered as part of a multimodal therapy approach. There is no convincing evidence supporting cellular-based therapy. The type of plication procedure used depends on the surgeon and patient preference, although excision of the tunica followed by plication may have a higher complication rate. There is currently no ideal graft, and graft contracture can occur postoperatively. Adjunctive procedures such as penile modeling, tunical plication, plaque incision\/excision and grafting can be performed when penile deformity and\/or penile curvature persist following penile prosthesis implantation.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The management of PD should be individualized based on the patient\u2019s needs and preferences while balancing the benefits and risks of each treatment option.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeaf068","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T12:56:58Z","timestamp":1763211418000},"source":"Crossref","is-referenced-by-count":8,"title":["Management of Peyronie\u2019s disease: recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024)"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-3668","authenticated-orcid":false,"given":"Eric","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Urology, Princess Alexandra Hospital, University of Queensland , Brisbane, QLD 4000 ,","place":["Australia"]},{"name":"AndroUrology Centre , Brisbane, QLD 4000 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Ziegelmann","sequence":"additional","affiliation":[{"name":"Department of Urology, Mayo Clinic , Rochester, MN 55905 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Third Hospital , Beijing, 100191 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