{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:18:22Z","timestamp":1788779902043,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Kidney transplantation is a life-saving intervention for patients with end-stage renal disease (ESRD), significantly improving longevity and quality of life compared to dialysis. However, despite these benefits, a considerable proportion of male recipients (20%\u201350%) continue to experience erectile dysfunction (ED), highlighting an ongoing concern in post-transplant health management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this review is to examine the role of kidney transplantation in addressing erectile dysfunction, with a particular focus on the interplay between hormonal changes, specifically testosterone and thyroid hormones and psychosocial factors such as anxiety, depression, and overall quality of life, by analyzing the multifactorial etiology of ED, including neurovascular, hormonal, and psychological dimensions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive analysis of existing literature was conducted, focusing on studies that examine ED prevalence, underlying mechanisms, and treatment approaches in kidney transplant recipients. Articles were selected based on their relevance to hormonal, psychological, and metabolic factors contributing to post-transplant sexual dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Findings indicate that persistent hormonal imbalances, including altered testosterone and thyroid hormone levels, significantly contribute to ED post-transplant. Additionally, psychosocial factors such as anxiety, depression, and reduced quality of life exacerbate the condition. Current therapeutic approaches emphasize a multidisciplinary framework that integrates hormonal regulation, psychological support, and metabolic management to address ED effectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Addressing ED in kidney transplant recipients requires a comprehensive approach that considers both physiological and psychological factors. Future research may focus on refining treatment protocols by incorporating hormonal therapies, mental health interventions, and lifestyle modifications to optimize sexual health outcomes and overall well-being in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeaf079","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:02:03Z","timestamp":1765976523000},"source":"Crossref","is-referenced-by-count":1,"title":["The role of kidney transplantation in the management of erectile dysfunction: a review of hormonal changes and psychosocial impacts in male patients"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3028-4093","authenticated-orcid":false,"given":"Muhammad Adil","family":"Malik","sequence":"first","affiliation":[{"name":"Third Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"issue":"1","key":"2026032603453968500_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","volume":"2","author":"Yafi","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"2026032603453968500_ref2","doi-asserted-by":"crossref","first-page":"5229702","DOI":"10.1155\/2022\/5229702","article-title":"Prevalence, comorbidities, and risk factors of erectile dysfunction: results from a prospective real-world study in the United Kingdom","volume":"2022","author":"Li","year":"2022","journal-title":"Int J Clin Pract"},{"issue":"1","key":"2026032603453968500_ref3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41443-017-0001-7","article-title":"Sexual dysfunction as a determinant of cardiovascular outcome in patients undergoing chronic hemodialysis","volume":"30","author":"Premu\u017ei\u0107","year":"2018","journal-title":"Int J Impot Res"},{"issue":"3","key":"2026032603453968500_ref4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.5527\/wjn.v4.i3.379","article-title":"Erectile dysfunction in chronic kidney disease: from pathophysiology to management","volume":"4","author":"Papadopoulou","year":"2015","journal-title":"World J Nephrol"},{"issue":"1","key":"2026032603453968500_ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.diabet.2011.09.003","article-title":"Erectile dysfunction and diabetes: a review of the current evidence-based medicine and a synthesis of the main available therapies","volume":"38","author":"Ph\u00e9","year":"2012","journal-title":"Diabetes Metab"},{"issue":"4","key":"2026032603453968500_ref6","first-page":"1820","article-title":"Does metabolic syndrome increase erectile dysfunction and lower urinary tract symptoms?","volume":"11","author":"Coban","year":"2014","journal-title":"Urol J"},{"issue":"2","key":"2026032603453968500_ref7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/MNH.0b013e32835021bd","article-title":"New insights into hypertension-associated erectile dysfunction","volume":"21","author":"Nunes","year":"2012","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"6","key":"2026032603453968500_ref8","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1046\/j.1365-2605.1998.00081.x","article-title":"The epidemiology of erectile dysfunction and its risk factors","volume":"20","author":"Bortolotti","year":"1998","journal-title":"Int J Androl"},{"key":"2026032603453968500_ref9","doi-asserted-by":"publisher","first-page":"807","DOI":"10.2147\/PPA.S99544","article-title":"Association of psychological factors, patients\u2019 knowledge, and management among patients with erectile dysfunction","volume":"10","author":"Huri","year":"2016","journal-title":"Patient Preference and Adherence"},{"issue":"2","key":"2026032603453968500_ref10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.21037\/tau.2018.09.04","article-title":"Erectile dysfunction in renal failure and transplant patients","volume":"8","author":"Fiuk","year":"2019","journal-title":"Transl Androl Urol"},{"issue":"3","key":"2026032603453968500_ref11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.eururo.2021.06.007","article-title":"European Association of Urology guidelines on sexual and reproductive Health-2021 update: male sexual dysfunction","volume":"80","author":"Salonia","year":"2021","journal-title":"Eur Urol"},{"issue":"1","key":"2026032603453968500_ref12","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/ki.1996.307","article-title":"A study of the quality of life and cost-utility of renal transplantation","volume":"50","author":"Laupacis","year":"1996","journal-title":"Kidney Int"},{"issue":"5","key":"2026032603453968500_ref13","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/s41443-021-00419-6","article-title":"Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis","volume":"34","author":"Rahman","year":"2022","journal-title":"Int J Impot Res"},{"key":"2026032603453968500_ref14","doi-asserted-by":"publisher","volume-title":"Annals of Medicine and Surgery. Elsevier","author":"Jabali","DOI":"10.1016\/j.amsu.2020.04.038"},{"issue":"6","key":"2026032603453968500_ref15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/sj.ijir.3901056","article-title":"Factors associated with erectile dysfunction in male kidney transplant recipients","volume":"15","author":"Rebollo","year":"2003","journal-title":"Int J Impot Res"},{"key":"2026032603453968500_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.07.141","article-title":"Analysis of sexual function in kidney transplanted men","volume":"40","author":"Barroso","journal-title":"Transplantation Proceedings. Elsevier"},{"issue":"10","key":"2026032603453968500_ref17","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1097\/00007890-200005270-00027","article-title":"High prevalence of erectile dysfunction after renal transplantation","volume":"69","author":"Malavaud","year":"2000","journal-title":"Transplantation."},{"key":"2026032603453968500_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(96)00072-3","article-title":"Effect of kidney transplantation and cyclosporine treatment on male sexual performance and hormonal profile: a prospective study","volume":"29","author":"Burgos","journal-title":"Transplantation Proceedings. Elsevier"},{"issue":"3","key":"2026032603453968500_ref19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1046\/j.1464-410X.2003.04323.x","article-title":"Effect of renal transplantation on sperm quality and sex hormone levels","volume":"92","author":"Akbari","year":"2003","journal-title":"BJU Int"},{"key":"2026032603453968500_ref20","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1016\/s0041-1345(98)00930-0","volume-title":"Male Sexual Performance and Hormonal Studies in Uremic Patients and Renal Transplant Recipients","author":"Chu","year":"1998"},{"issue":"6","key":"2026032603453968500_ref21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/01485010290099381","article-title":"Effect of renal transplantation on sexual function","volume":"48","author":"Tsujimura","year":"2002","journal-title":"Arch Androl"},{"issue":"2","key":"2026032603453968500_ref22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000166785","article-title":"Disturbances in the hypothalamic-pituitary-gonadal axis in male patients with acute renal failure","volume":"4","author":"Levitan","year":"1984","journal-title":"Am J Nephrol"},{"issue":"3","key":"2026032603453968500_ref23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jsxm.2016.01.007","article-title":"Endocrinologic control of men\u2019s sexual desire and arousal\/erection","volume":"13","author":"Corona","year":"2016","journal-title":"J Sex Med"},{"issue":"6","key":"2026032603453968500_ref24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000180907","article-title":"Impotence in patients with uremia","volume":"19","author":"Massry","year":"1977","journal-title":"Nephron."},{"issue":"5","key":"2026032603453968500_ref25","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/S1072-7515(01)01060-2","article-title":"Improvement of sexual function in male patients after parathyroidectomy for secondary hyperparathyroidism","volume":"193","author":"Chou","year":"2001","journal-title":"J Am Coll Surg"},{"issue":"1","key":"2026032603453968500_ref26","first-page":"405","article-title":"The role of hypothyroidism in male infertility and erectile dysfunction","volume":"9","author":"Nikoobakht","year":"2012","journal-title":"Urol J"},{"key":"2026032603453968500_ref27","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3389\/fimmu.2018.01130","article-title":"Endothelial dysfunction in kidney transplantation","volume":"9","author":"Cardinal","year":"2018","journal-title":"Front Immunol"},{"issue":"12","key":"2026032603453968500_ref28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.amjcard.2005.10.007","article-title":"Sexual dysfunction and cardiovascular disease: integrative concepts and strategies","volume":"96","author":"Billups","year":"2005","journal-title":"Am J Cardiol"},{"issue":"5","key":"2026032603453968500_ref29","first-page":"239","article-title":"Cardiovascular disease and mortality in ESRD","volume":"11","author":"Foley","year":"1998","journal-title":"J Nephrol"},{"issue":"2 SUPPL. 1","key":"2026032603453968500_ref30","first-page":"i-ii+ S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"Levey","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"2026032603453968500_ref32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5534\/wjmh.190151","article-title":"Vitamin D and male erectile function: an updated review","volume":"39","author":"Onder Canguven","year":"2020","journal-title":"World J Men's Health"},{"issue":"16","key":"2026032603453968500_ref33","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.3390\/nu14163438","article-title":"Testosterone deficiency as one of the major endocrine disorders in chronic kidney disease","volume":"14","author":"Romejko","year":"2022","journal-title":"Nutrients."},{"key":"2026032603453968500_ref34","volume":"6","author":"Sen","journal-title":"Journal of the Islamic Academy of Sciences, Nephrology"},{"issue":"6","key":"2026032603453968500_ref35","doi-asserted-by":"publisher","first-page":"814","DOI":"10.21037\/tau.2016.07.09","article-title":"A case series of the safety and efficacy of testosterone replacement therapy in renal failure and kidney transplant patients","volume":"5","author":"Majzoub","year":"2016","journal-title":"Transl Androl Urol"},{"issue":"2","key":"2026032603453968500_ref36","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1056\/NEJMoa1000485","article-title":"Adverse events associated with testosterone administration","volume":"363","author":"Basaria","year":"2010","journal-title":"N Engl J Med"},{"issue":"5","key":"2026032603453968500_ref37","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1097\/JU.0000000000000396","article-title":"Long-term safety and efficacy of clomiphene citrate for the treatment of hypogonadism","volume":"202","author":"Krzastek","year":"2019","journal-title":"J Urol"},{"issue":"3","key":"2026032603453968500_ref38","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/sj.ijir.3900981","article-title":"Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit?","volume":"15","author":"Guay","year":"2003","journal-title":"Int J Impot Res"},{"key":"2026032603453968500_ref39","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fpsyt.2020.00106","article-title":"Psychological and psychopathological aspects of kidney transplantation: a systematic review","volume":"11","author":"De Pasquale","year":"2020","journal-title":"Front Psychiatry"},{"issue":"4","key":"2026032603453968500_ref40","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4103\/0971-5916.159268","article-title":"Organ transplant & the psychiatrist: an overview","volume":"141","author":"Kumar","year":"2015","journal-title":"Indian J Med Res"},{"key":"2026032603453968500_ref41","doi-asserted-by":"publisher","volume-title":"Cognitive-Behavioral Therapy for Sexual Dysfunction","author":"Metz","DOI":"10.4324\/9780203863459"},{"issue":"6","key":"2026032603453968500_ref42","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.eururo.2008.09.020","article-title":"Renal transplantation does not improve erectile function in hemodialysed patients","volume":"56","author":"Mirone","year":"2009","journal-title":"Eur Urol"},{"issue":"2","key":"2026032603453968500_ref43","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1399-0012.2010.01237.x","article-title":"Improved erectile function and sex hormone profiles in male Chinese recipients of kidney transplantation","volume":"25","author":"Teng","year":"2011","journal-title":"Clin Transpl"},{"issue":"3","key":"2026032603453968500_ref44","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.euf.2018.08.012","article-title":"Does solid organ transplantation affect male reproduction?","volume":"4","author":"Thirumavalavan","year":"2018","journal-title":"European Urol Focus"},{"issue":"1","key":"2026032603453968500_ref45","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1053\/j.ajkd.2006.04.061","article-title":"Treatment of erectile dysfunction with sildenafil citrate in renal allograft recipients: a randomized, double-blind, placebo-controlled, crossover trial","volume":"48","author":"Sharma","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"2026032603453968500_ref46","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1016\/j.transproceed.2024.05.020","article-title":"Renal transplantation enhances the sildenafil citrate effectiveness in patients with erectile dysfunction. A single-Center perspective","volume":"56","author":"El Hennawy","year":"2024","journal-title":"Elsevier"},{"key":"2026032603453968500_ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-024-04299-9","article-title":"Prevalence, risk factors, and severity of erectile dysfunction following renal transplantation","volume":"57","author":"Miron","journal-title":"Int Urol Nephrol."},{"issue":"3","key":"2026032603453968500_ref48","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/2090598X.2019.1600990","article-title":"The correlation between erectile dysfunction and metabolic syndrome in an Indian population: a cross-sectional observational study","volume":"17","author":"Sood","year":"2019","journal-title":"Arab J Urol"}],"container-title":["Sexual Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/smr\/article-pdf\/14\/1\/qeaf079\/67510857\/qeaf079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/smr\/article-pdf\/14\/1\/qeaf079\/67510857\/qeaf079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:45:43Z","timestamp":1774511143000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/smr\/article\/doi\/10.1093\/sxmrev\/qeaf079\/8540482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,5]]}},"URL":"https:\/\/doi.org\/10.1093\/sxmrev\/qeaf079","relation":{},"ISSN":["2050-0513","2050-0521"],"issn-type":[{"value":"2050-0513","type":"print"},{"value":"2050-0521","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]},"article-number":"qeaf079"}}