{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T19:59:10Z","timestamp":1771703950576,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rez\u016bm water vapor thermal therapy (WVTT) is a safe and effective treatment for lower urinary tract symptoms\/benign prostatic hyperplasia (BPH) in patients with prostate sizes between 30 and 80\u00a0cm3 and preserves sexual function. However, its effect on sexual function in patients with large prostate volumes (\u226580\u00a0cm3) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review aims to assess the association of prostate size with sexual function outcomes in lower urinary tract symptoms\/benign prostatic hyperplasia patients after treatment with WVTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medline and Embase were searched (2013-2024) to identify articles reporting sexual function outcomes for both average (\u226480\u00a0cm3) and large gland (&amp;gt;80\u00a0cm3) patients within the same study at baseline and \u226512\u00a0months. Adverse events impacting sexual function, postoperative benign prostatic hyperplasia medication usage, and baseline\/\u226512-month data for sexual function outcomes were extracted in DistillerSR. Outcomes were summarized for each subgroup (average gland, large gland). ROBINS-I was used to assess risk of bias, and the Grading of Recommendations, Assessment, Development and Evaluation system was used to assess certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 394 articles, 4 were included. Corresponding to three distinct studies reporting sexual function outcomes at baseline and \u226512\u00a0months post-WVTT (306 average and 85 large gland patients at baseline). Scales included International Index of Erectile Function (IIEF)-15, IIEF-5 (Sexual Health Inventory for Men-SHIM), IIEF-Ejaculatory Function (EF) Domain, Male Sexual Health Questionnaire-Ejaculatory Dysfunction (MSHQ-EjD) Bother, and MSHQ-EjD Function. At follow-up, all three studies reported no clinically significant associations between sexual function outcomes and prostate size for large gland and average gland patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite limited studies reporting sexual function outcomes in both average and large gland patients, this systematic review showed there was no clinically meaningful association between prostate size and erectile or ejaculatory function at \u226512\u00a0months after WVTT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeag007","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:48:46Z","timestamp":1770986926000},"source":"Crossref","is-referenced-by-count":0,"title":["A systematic review of associations\u2014exploring whether prostate size is related to sexual function outcomes following water vapor thermal therapy"],"prefix":"10.1093","volume":"14","author":[{"given":"Philip","family":"Westbrook","sequence":"first","affiliation":[{"name":"Center for Male Health, Loyola University Chicago, Stritch School of Medicine , Maywood, IL 60153 ,","place":["United States"]},{"name":"Loyola University Chicago , Chicago, IL 60660 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmer","family":"Farooq","sequence":"additional","affiliation":[{"name":"Center for Male Health, Loyola University Chicago, Stritch School of Medicine , Maywood, IL 60153 ,","place":["United States"]},{"name":"Loyola University Chicago , Chicago, IL 60660 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8882-4273","authenticated-orcid":false,"given":"Golnaz","family":"Venkatraman","sequence":"additional","affiliation":[{"name":"Boston Scientific , Marlborough, MA 01752 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Searcy","sequence":"additional","affiliation":[{"name":"Boston Scientific , Marlborough, MA 01752 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kerian","sequence":"additional","affiliation":[{"name":"Boston Scientific , Marlborough, MA 01752 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyson","family":"Rogers","sequence":"additional","affiliation":[{"name":"NAMSA , Minneapolis, MN 55433 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin T","family":"McVary","sequence":"additional","affiliation":[{"name":"Center for Male Health, Loyola University Chicago, Stritch School of Medicine , Maywood, IL 60153 ,","place":["United States"]},{"name":"Loyola University Chicago , Chicago, IL 60660 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"issue":"1","key":"2026022113594527700_ref1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/JU.0000000000003698","article-title":"Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA guideline (published 2021; amended 2023)","volume":"211","author":"Sandhu","year":"2023","journal-title":"J Urol"},{"issue":"3","key":"2026022113594527700_ref2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41391-023-00743-6","article-title":"Comparison of perioperative and short-terms outcomes of en-bloc Holmium laser enucleation of the prostate (HoLEP) and robot-assisted simple prostatectomy: a propensity-score matching analysis","volume":"27","author":"Grosso","year":"2024","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"2","key":"2026022113594527700_ref3","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00345-018-2368-6","article-title":"Do patients have to choose between ejaculation and miction? 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