{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:25:14Z","timestamp":1772213114783,"version":"3.50.1"},"reference-count":235,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"MUR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Recovery and Resilience Plan"},{"name":"Italian Ministry of University","award":["2022AWB8T4"],"award-info":[{"award-number":["2022AWB8T4"]}]},{"name":"Italian Ministry of University","award":["P2022SE38P_004"],"award-info":[{"award-number":["P2022SE38P_004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Alcohol has been a central part of human culture for millennia and is closely linked to sexual behavior, a relationship portrayed in both negative and positive terms, from impaired performance to enhanced desire. Its influence on male sexual function is complex, shaped by biological, psychological, and social factors, as well as patterns and levels of consumption.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This review aims to summarize current evidence on the effects of acute and chronic alcohol consumption on male sexual function, highlighting mechanisms, patterns of use, and clinical implications.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A PubMed search using MeSH terms and keywords related to alcohol and male sexual dysfunction (SD) yielded 599 articles. Relevant studies were selected for inclusion in this non-systematic narrative review, integrating findings from epidemiological, experimental, and clinical research.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Alcohol exerts complex pathophysiological and psychological effects\u2014ranging from cardiovascular, hormonal, and neurological alterations to cognitive, emotional, and behavioral changes\u2014that together shape its multifaceted impact on male sexual function. Social and cultural factors may further modulate this relationship. Light-to-moderate intake can have neutral or modestly protective effects on erectile function and may facilitate sexual activity. In contrast, heavy or binge consumption is consistently associated with erectile dysfunction, may contribute to ejaculatory disorders, and is linked to a reduced overall sexual quality of life. Chronic alcohol abuse, as seen in Alcohol Use Disorders (AUD), exacerbates sexual impairment through physiological toxicity, psychosocial stressors, and psychiatric comorbidities, while SD can, in turn, promote maladaptive drinking behaviors, creating a bidirectional relationship.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Alcohol\u2019s impact on male sexual function is dose- and context-dependent. While moderate intake appears benign, excessive consumption leads to significant SD that might, in turn, contribute to AUD. The systems sexology framework provides a holistic lens to understand how 4 interrelated domains (mind, body, experience, and society) interact in shaping alcohol-sex relationship, informing prevention and therapeutic strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/sxmrev\/qeag008","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:46:54Z","timestamp":1770209214000},"source":"Crossref","is-referenced-by-count":0,"title":["Judith and Holofernes: alcohol's role in male sexual health in the light of the systems sexology"],"prefix":"10.1093","volume":"14","author":[{"given":"Dimitri","family":"Yannas","sequence":"first","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata , Rome 00133 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-2843","authenticated-orcid":false,"given":"Andrea","family":"Sansone","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata , Rome 00133 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-9031","authenticated-orcid":false,"given":"Angelo","family":"Cignarelli","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro , Bari 70124 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-7105","authenticated-orcid":false,"given":"Daniele","family":"Santi","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena , Modena 41125 ,","place":["Italy"]},{"name":"Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena 41125 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Spaggiari","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena , Modena 41125 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-2678","authenticated-orcid":false,"given":"Francesco","family":"Giorgino","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro , Bari 70124 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2936-4150","authenticated-orcid":false,"given":"Tommaso B","family":"Jannini","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata , Rome 00133 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Siracusano","sequence":"additional","affiliation":[{"name":"Superior Health Council, Italian Ministry of Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-039X","authenticated-orcid":false,"given":"Emmanuele A","family":"Jannini","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata , Rome 00133 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"2026022711413428100_ref1","volume-title":"Global Status Report on Alcohol and Health and Treatment of Substance Use Disorders","author":"World Health Organization","year":"2024"},{"key":"2026022711413428100_ref2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1465-3362.2011.00374.x","article-title":"Understanding standard drinks and drinking guidelines","volume":"31","author":"Kerr","year":"2012","journal-title":"Drug Alcohol Rev"},{"key":"2026022711413428100_ref3","volume-title":"Understanding Alcohol Drinking Patterns | National Institute on Alcohol Abuse and Alcoholism (NIAAA)","author":"National Institute on Alcohol Abuse and Alcoholism"},{"key":"2026022711413428100_ref4","volume-title":"Facts about Excessive Drinking. 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