{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:39:19Z","timestamp":1792895959307,"version":"4.5.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Angus Association"},{"name":"Angus Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Heart disease, specifically congestive heart failure, has become of increased interest to geneticists and cattle feeders. Data on cohort associations of risk factors related to heart disease and when heart disease deaths occur in U.S. feedlot cattle are limited. The study objectives were to 1) determine potential associations between feedlot cohort demographics and the risk of at least one noninfectious heart disease (NIHD) death occurrence and 2) determine potential association between feedlot cohort demographics and the timing of NIHD deaths during the feeding phase. Data were downloaded from commercial feedyard software and analyzed by constructing a generalized linear mixed model for both analyses. A binomial and Gaussian distributions for risk of NIHD death and timing of NIHD were utilized as link functions for their respective models. Our study population consisted of 28,950 cohorts (representing 4,596,205 cattle) that were placed in 22 U.S. commercial feedlots from January 01, 2016, to January 01, 2019. There were 3,282 cases of NIHD deaths from a population of 75,963 cattle that died during the 3-yr study period. Average cohort arrival weight\u2019s effect on NIHD probability was influenced by arrival quarter and arrival year of placement (P &amp;lt; 0.01). Cohorts with steers were associated with a greater probability of at least one NIHD death (2.38%) compared with heifers (1.95%; P &amp;lt; 0.01). Increasing cohort size was associated with an increased probability of a cohort having at least one NIHD death (P &amp;lt; 0.01). The probability of a cohort having at least one NIHD death increased with increasing DOF categories from 1.51% in cattle fed 100 to 175 d, to 2.12% in cattle fed 176 to 250 d, and 2.87% for cattle fed 251 to 326 d. Cattle &amp;gt; 326 DOF were no different in the probability of a NIHD death compared with the other feeding categories. Timing of a NIHD death had a mean and median occurrence of 110 DOF with an interquartile range of 64 to 153 DOF. The effect of arrival weight on days at death was influenced by year placed with heavier cattle generally decreasing the model adjusted means of DOF at NIHD death. Arrival quarter was influenced by year placed on model adjusted means on the timing of a NIHD death. Steers with NIHD died later compared with heifers (P &amp;lt; 0.01) diagnosed with NIHD. In conclusion, multiple factors are associated with the probability and timing of a NIHD death. Probability of having at least one NIHD death within a cohort was low, and half of the deaths occurred before 110 DOF.<\/jats:p>","DOI":"10.1093\/tas\/txab220","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T05:23:22Z","timestamp":1638336202000},"source":"Crossref","is-referenced-by-count":14,"title":["Retrospective analysis of cohort risk factors and feeding phase timing associated with noninfectious heart disease deaths in U.S. feedlot cattle"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-6515","authenticated-orcid":false,"given":"Blaine T","family":"Johnson","sequence":"first","affiliation":[{"name":"Beef Cattle Institute, Kansas State University, Manhattan, KS 66506, USA"},{"name":"Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Amrine","sequence":"additional","affiliation":[{"name":"Beef Cattle Institute, Kansas State University, Manhattan, KS 66506, USA"},{"name":"Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Larson","sequence":"additional","affiliation":[{"name":"Beef Cattle Institute, Kansas State University, Manhattan, KS 66506, USA"},{"name":"Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3461-4214","authenticated-orcid":false,"given":"Robert L","family":"Weaber","sequence":"additional","affiliation":[{"name":"Beef Cattle Institute, Kansas State University, Manhattan, KS 66506, USA"},{"name":"Department of Animal Science and Industry, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad J","family":"White","sequence":"additional","affiliation":[{"name":"Beef Cattle Institute, Kansas State University, Manhattan, KS 66506, USA"},{"name":"Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"2021121718262497600_CIT0001","volume-title":"Evaluating the epidemiology and management of bovine congestive heart failure","author":"Bassett","year":"2019"},{"issue":"1","key":"2021121718262497600_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. 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Charlottetown,","author":"Dohoo","year":"2012","journal-title":"P.E.I.: VER, Inc"},{"key":"2021121718262497600_CIT0004","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.12688\/f1000research.19951.1","article-title":"Evaluation of EPAS1 variants for association with bovine congestive heart failure","volume":"8","author":"Heaton","year":"2019","journal-title":"F1000Res"},{"key":"2021121718262497600_CIT0005","doi-asserted-by":"crossref","first-page":"2045894018796804","DOI":"10.1177\/2045894018796804","article-title":"Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity-associated pulmonary hypertension with left heart disease","volume":"9","author":"Krafsur","year":"2019","journal-title":"Pulm. Circ"},{"key":"2021121718262497600_CIT0006","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1040638719855108","article-title":"Investigation of congestive heart failure in beef cattle in a feedyard at a moderate altitude in western Nebraska","volume":"31","author":"Moxley","year":"2019","journal-title":"J. Vet. Diagn. Invest"},{"key":"2021121718262497600_CIT0007","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jvim.13789","article-title":"Right-sided congestive heart failure in North American feedlot cattle","volume":"30","author":"Neary","year":"2016","journal-title":"J. Vet. Intern. Med"},{"key":"2021121718262497600_CIT0008","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.2527\/jas.2015-9048","article-title":"Mean pulmonary arterial pressures in Angus steers increase from cow-calf to feedlot-finishing phases","volume":"93","author":"Neary","year":"2015","journal-title":"J. Anim. 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