{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:02:41Z","timestamp":1784250161352,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This experiment evaluated the effects of supplementing narasin during late-gestation and lactation on productive and physiological responses of Bos indicus beef heifers and their offspring. Pregnant, nulliparous Nelore heifers (N = 88) that conceived under the same fixed-time artificial insemination protocol and to the same sire were used. Heifers were ranked by maternal ability genomic score, body weight (BW) and body condition score (BCS) and allocated to 44 drylot pens (2 heifers per pen; 10 \u00d7 25 m). Pens were ranked by these traits and alternatively assigned to receive (NAR) or not (CON) 0.260 mg of narasin\/kg of heifer BW daily (Elanco Sa\u00fade Animal, S\u00e3o Paulo, Brazil). Narasin was mixed into a supplement offered at 0.30% of heifer BW from day 0 until heifers weaned their calves (day 316), whereas CON heifers received the same supplement without narasin addition. Heifers received Urochloa brizantha hay and water for ad libitum consumption (days 0 to 316) and calved between days 97 to 112 of the experiment. After calving, heifers and offspring had access to hay and supplement; hence, supplements and narasin were offered according to heifer + calf BW beginning on day 162. No treatment differences were detected (P \u2265 0.18) for heifer BW and BCS during the experiment, although BW loss from day 0 to calving was less (P = 0.04) in NAR compared to CON heifers. Hay intake during the experiment did not differ (P = 0.79) between treatments. Serum IGF-I concentrations were greater (P = 0.05) for NAR heifers on day 60 of the experiment and did not differ (P \u2265 0.28) between treatments 24 h and 30 d after calving (treatment \u00d7 day interaction; P = 0.04). No treatment effects were detected (P \u2265 0.58) for calf birth BW. Serum concentrations of total protein 24 h after birth were greater (P = 0.04) in calves from NAR compared with CON heifers, and a tendency (P = 0.10) for a similar outcome was noted for serum IgG concentrations. Diarrhea incidence did not differ (P = 0.16) between treatments, although the number of total diarrhea cases per calf were greater (P = 0.03) in the CON offspring. Growth rate of calves from NAR heifers tended (P = 0.08) to be greater, resulting in heavier calves at weaning (P \u2264 0.04) compared with CON offspring. Collectively, these outcomes indicate narasin supplementation to beef heifers as a nutritional alternative to improve cow\u2013calf productivity via developmental programming effects during gestation, as well as direct consumption by their nursing offspring.<\/jats:p>","DOI":"10.1093\/tas\/txad023","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T16:55:22Z","timestamp":1677689722000},"source":"Crossref","is-referenced-by-count":5,"title":["Effects of supplementing narasin to<i>Bos indicus<\/i>heifers during late-gestation and lactation on development of the offspring"],"prefix":"10.1093","volume":"7","author":[{"given":"Victor F B","family":"Miranda","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Estadual Paulista , Botucatu, SP 18618-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-3601","authenticated-orcid":false,"given":"Reinaldo F","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX 77845 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro V F","family":"Lasmar","sequence":"additional","affiliation":[{"name":"Elanco Animal Health , Sao Paulo, SP 04703-002 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E D","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Estadual Paulista , Botucatu, SP 18618-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Burato","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Estadual Paulista , Botucatu, SP 18618-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio L C","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Estadual Paulista , Botucatu, SP 18618-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hingryd A O","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Estadual Paulista , Botucatu, SP 18618-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8589-010X","authenticated-orcid":false,"given":"Eduardo A","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX 77845 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo L","family":"Valarelli","sequence":"additional","affiliation":[{"name":"Elanco Animal Health , Sao Paulo, SP 04703-002 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Leiva","sequence":"additional","affiliation":[{"name":"Elanco Animal Health , Sao Paulo, SP 04703-002 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L M","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Estadual Paulista , Botucatu, SP 18618-970 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"2023082810405216000_CIT0001","doi-asserted-by":"crossref","first-page":"399","DOI":"10.15232\/S1080-7446(15)31455-8","article-title":"The effects of scours on calf weaning weight","volume":"19","author":"Anderson","year":"2003","journal-title":"Prof. Anim. Sci"},{"key":"2023082810405216000_CIT0002","volume-title":"Official methods of analysis","author":"AOAC.","year":"2006","edition":"18"},{"key":"2023082810405216000_CIT0003","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.2527\/jas1984.5861465x","article-title":"Ionophores: their effect on production efficiency and mode of action","volume":"58","author":"Bergen","year":"1984","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0749-0720(15)30591-0","article-title":"The importance of colostrum to the health of the neonatal calf","volume":"10","author":"Besser","year":"1994","journal-title":"Vet. Clin. North Am. Food Anim. Pract"},{"key":"2023082810405216000_CIT0005","volume-title":"Guidelines for uniform beef improvement programs","author":"BIF (Beef Improvement Federation).","year":"2010","edition":"9"},{"key":"2023082810405216000_CIT0006","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.2527\/jas.2013-6301","article-title":"Late gestation supplementation of beef cows differing in body condition score: effects on cow and calf performance","volume":"91","author":"Bohnert","year":"2013","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0007","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1093\/jas\/skaa278.353","article-title":"Supplementing Ca salts of soybean oil to late-gestating beef cows: impacts on performance and physiological responses of the offspring","volume":"98","author":"Brand\u00e3o","year":"2020","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0008","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/tas\/txy113","article-title":"Effects of supplement type and narasin inclusion on supplement intake by Bos indicus beef bulls grazing a warm-season forage","volume":"3","author":"Cappellozza","year":"2019","journal-title":"Transl. Anim. Sci"},{"key":"2023082810405216000_CIT0009","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.2527\/jas.2011-4959","article-title":"Plasma progesterone concentration in beef heifers receiving exogenous glucose, insulin, or bovine somatotropin","volume":"90","author":"Cooke","year":"2012","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0010","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.3168\/jds.2014-7939","article-title":"Evaluation of a Brix refractometer to estimate serum immunoglobulin G concentration in neonatal dairy calves","volume":"97","author":"Deelen","year":"2014","journal-title":"J. Dairy Sci"},{"key":"2023082810405216000_CIT0011","doi-asserted-by":"crossref","first-page":"914","DOI":"10.2460\/javma.228.6.914","article-title":"Association of neonatal serum immunoglobulin G1 concentration with health and performance in beef calves.","volume":"228","author":"Dewell","year":"2006","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"2023082810405216000_CIT0012","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.2527\/jas.2009-2351","article-title":"Effects of maternal nutrition on conceptus growth and offspring performance: implications for beef cattle production","volume":"88","author":"Funston","year":"2010","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0013","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.2527\/2005.8313_supplE90x","article-title":"Nutritional controls of beef cow reproduction","volume":"83","author":"Hess","year":"2005","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0014","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.2527\/1990.6892622x","article-title":"Influence of nutritional restriction during late gestation on production measures and passive immunity in beef cattle","volume":"68","author":"Hough","year":"1990","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/nu3040442","article-title":"Perspectives on immunoglobulins in colostrum and milk","volume":"3","author":"Hurley","year":"2011","journal-title":"Nutrients"},{"key":"2023082810405216000_CIT0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skab005","article-title":"Effects of supplementation with narasin, salinomicyn or flavomicyn on performance and ruminal fermentation characteristics of Bos indicus Nellore cattle fed with forage-based diets","volume":"99","author":"Limede","year":"2021","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0017","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.3390\/ani11102871","article-title":"Effects of ionophores on ruminal function of beef cattle","volume":"11","author":"Marques","year":"2021","journal-title":"Animals"},{"key":"2023082810405216000_CIT0018","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.livsci.2016.08.007","article-title":"Impacts of cow body condition score during gestation on weaning performance of the offspring","volume":"191","author":"Marques","year":"2016","journal-title":"Livest. Sci"},{"key":"2023082810405216000_CIT0019","doi-asserted-by":"crossref","first-page":"728635","DOI":"10.3389\/fanim.2021.728635","article-title":"Improving beef cattle performance through developmental programming","volume":"2","author":"Moriel","year":"2021","journal-title":"Front. Anim. Sci"},{"key":"2023082810405216000_CIT0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jas\/skaa236","article-title":"Supplementation frequency and amount modulate postweaning growth and reproductive performance of Bos indicus-influenced beef heifers","volume":"98","author":"Moriel","year":"2020","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0021","volume-title":"Nutrient requirements of beef cattle. 8th ed. Animal Nutrition Series","author":"NASEM (National Academics of Sciences, Engineering, and Medicine).","year":"2016"},{"key":"2023082810405216000_CIT0022","doi-asserted-by":"crossref","first-page":"skac003","DOI":"10.1093\/jas\/skac003","article-title":"Effects of maternal winter vs. year-round supplementation of protein and energy on postnatal growth, immune function, and carcass characteristics of Bos indicus-influenced beef offspring","volume":"100","author":"Palmer","year":"2022","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0023","doi-asserted-by":"crossref","first-page":"e0272236","DOI":"10.1371\/journal.pone.0272236","article-title":"Performance and muscle lipogenesis of calves born to Nellore cows with different residual feed intake classification","volume":"17","author":"Paz","year":"2022","journal-title":"PLoS One"},{"key":"2023082810405216000_CIT0024","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.theriogenology.2014.06.008","article-title":"Effect of interval from induction of puberty to initiation of a timed AI protocol on pregnancy rate in Nellore heifers","volume":"82","author":"Rodrigues","year":"2014","journal-title":"Theriogenology"},{"key":"2023082810405216000_CIT0025","first-page":"83","volume-title":"Manipulation of the fermentation and digestion to optimize the use of forage resources for ruminant production. In: Isotope and related techniques in animal production and health","author":"Rowe","year":"1991"},{"key":"2023082810405216000_CIT0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tas\/txab125","article-title":"Effects of narasin supplementation frequency on intake, ruminal fermentation parameters, and nutriente digestibility of Bos indicus Nellore steers fed with with forage-based diets","volume":"5","author":"Soares","year":"2021","journal-title":"Transl. Anim. Sci"},{"key":"2023082810405216000_CIT0027","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.2527\/jas.2005-640","article-title":"Effects of pre-and postpartum nutrition on reproduction in spring calving cows and calf feedlot performance","volume":"84","author":"Stalker","year":"2006","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0028","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","article-title":"Methods for dietary \ufb01ber, neutral detergent \ufb01ber, and nonstarch polysaccharides in relation to animal nutrition","volume":"74","author":"Van Soest","year":"1991","journal-title":"J. Dairy Sci"},{"key":"2023082810405216000_CIT0029","doi-asserted-by":"crossref","first-page":"txac105","DOI":"10.1093\/tas\/txac105","article-title":"Monensin supplementation during late gestation of beef cows alters maternal plasma concentrations of insulin-like growth factors 1 and 2 and enhances offspring preweaning growth","volume":"6","author":"Vedovatto","year":"2022","journal-title":"Transl. Anim. Sci"},{"key":"2023082810405216000_CIT0030","first-page":"5112","article-title":"Effects of monensin inclusion into increasing amount of concentrate on growth and physiological parameters of early-weaned beef calves consuming warm-season grasses","volume":"96","author":"Vendramini","year":"2018","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0031","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.2527\/jas.2015-8913","article-title":"Stocking rate and monensin supplementation effects on performance of beef cattle consuming warm-season grasses","volume":"93","author":"Vendramini","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0032","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2527\/jas1988.663603x","article-title":"Carcass composition in mature Hereford cows: estimation and effect on daily metabolizable energy requirement during winter","volume":"66","author":"Wagner","year":"1988","journal-title":"J. Anim. Sci"},{"key":"2023082810405216000_CIT0033","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.2460\/ajvr.1995.56.09.1149","article-title":"Passive immune status at postpartum hour 24 and long-term health and performance of calves","volume":"56","author":"Wittum","year":"1995","journal-title":"Am. J. Vet. Res"}],"container-title":["Translational Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/tas\/advance-article-pdf\/doi\/10.1093\/tas\/txad023\/49356179\/txad023.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/tas\/article-pdf\/7\/1\/txad023\/51276210\/txad023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/tas\/article-pdf\/7\/1\/txad023\/51276210\/txad023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T14:01:25Z","timestamp":1729000885000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tas\/article\/doi\/10.1093\/tas\/txad023\/7060215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/tas\/txad023","relation":{},"ISSN":["2573-2102"],"issn-type":[{"value":"2573-2102","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"txad023"}}