{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:18:39Z","timestamp":1753877919825,"version":"3.41.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":148,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008370","name":"National Pork Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Two hundred and forty newly weaned pigs (PIC, Hendersonville, TN) were used to determine if supplementing additional arginine (Arg) either in the water or in the feed, and the combinations thereof, improved intestinal integrity and growth performance in nursery pigs. Each of the 80 pens contained three pigs (21 \u00b1 2 d of age) which were randomly allotted to treatments in 4 \u00d7 3 factorial arrangement consisting of four water treatments (0%, 4%, 8%, and 12% Arg stock delivered through a 1:128 medication delivery system) in combination with three dietary Arg treatments (1.35%, 1.55%, and 1.75% standardized ileal digestible Arg; SID). Pigs and feeders were weighed at the d0, d6 (water and diet change), d20 (diet change), and d41 for the calculation of average daily gain (ADG), average daily feed intake (ADFI), and feed efficiency (G:F). Eighty pigs, 1 pig\/pen, were euthanized at d6 for ileum evaluation of villus height and crypt depth. The remaining pigs were taken off the Arg-water treatment and fed phase-2 diets formulated to contain 1.35%, 1.55%, and 1.75% SID Arg. All pigs received a common diet from d20 to d41. Data were analyzed by pen as repeated measures (SAS 9.4). No interaction between water- and dietary-Arg was detected on nursery pig growth performance. There was a significant quadratic effect of SID Arg in the feed on pig final body weight (BW), ADG, ADFI, and G:F (P \u2264 0.037), where feeding 1.55% dietary Arg tended to improve growth performance compared to the 1.35% level for the 41 d of the trial (P \u2264 0.088). The use of the stock 8% Arg in the water resulted in a reduction in crypt depth (0:132.5, 4:140.7, 8:117.3, 12:132.0; P \u2264 0.01) and an improvement in intestinal permeability. The 4% oral Arg significantly reduced villous height:crypt depth ratio (0:2.50, 4:2.09, 8:2.56, 12:2.43; P \u2264 0.02). In conclusion, the feeding of 1.55% Arg resulted in an improvement in nursery pig ADG, ADFI, G:F, and final BW but did not alter intestinal villi morphology; however, the use of Arg in the water resulted in an improvement in intestinal villi, but no phenotypical change in piglet growth in the nursery.<\/jats:p>","DOI":"10.1093\/tas\/txad059","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:52:22Z","timestamp":1685361142000},"source":"Crossref","is-referenced-by-count":5,"title":["Water- and feed-based arginine impacts on gut integrity in weanling pigs"],"prefix":"10.1093","volume":"7","author":[{"given":"Laura","family":"Greiner","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalton","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Kerr","sequence":"additional","affiliation":[{"name":"USDA ARS, ARS National Laboratory for Agriculture and Environment , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spenser","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Breuer","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Elefson","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Haydon","sequence":"additional","affiliation":[{"name":"CJ America \u2013 Bio , Fort Dodge, IA 50501 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"2023082810301008900_CIT0001","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2527\/jas1984.582369x","article-title":"Effects of excess arginine with and without supplemental lysine on performance, plasma amino acid concentrations and nitrogen balance of young swine","volume":"58","author":"Anderson","year":"1984","journal-title":"J. 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