{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:17:29Z","timestamp":1753877849166,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:00:00Z","timestamp":1692403200000},"content-version":"vor","delay-in-days":230,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The study\u2019s aim was to evaluate the effect of dietary Zn supplementation on steer performance, biomarkers of inflammation and metabolism, and liver abscess formation in response to a mild acidosis challenge. Forty-two steers (417 \u00b1 3.99 kg; n = 6\/pen) were housed in pens with bunks designed to measure individual dry matter intake (DMI) and fed one of two diets containing either 0 (CON; n = 18) or 90 mg Zn\/kg from a Zn-amino acid complex (Zn-AA; n = 18; AvailaZn; Zinpro) for 109 d. Six additional steers were fed the CON diet and did not undergo the acidosis challenge (NON; n = 6). The acidosis challenge included restricting steers to 50% of the previous 7 d daily DMI on days 46 and 47, steers were individually provided 10% of DMI as cracked corn (as-fed) at 0800 h followed by ad libitum feed access 2 h post-grain consumption. Steer was the experimental unit, and two contrasts were constructed: NON vs. CON and CON vs. Zn-AA. Blood samples were collected on days 40, 48, 53, 69, 80, and 108 and analyzed as repeated measures. Final body weight and overall average daily gain (2.29, 2.30, and 2.31 \u00b1 0.920 kg\/d for CON, Zn-AA, and NON, respectively) were not different (P \u2265 0.74) between treatments. By design, DMI was greater (P &amp;lt; 0.01) for NON compared to CON on day 46 but was not different (P \u2265 0.41) for the rest of the experiment. While hot carcass weight (423, 428, and 424 \u00b1 7.9 kg for CON, Zn-AA, and NON, respectively) and ribeye area were not different (P \u2265 0.53) due to treatment, marbling score tended (P = 0.06) to be greater in CON compared to Zn-AA. The 12th rib backfat thickness was greater (P = 0.05) in NON vs. CON steers. Liver abscess incidence tended to be greater (P = 0.12) in CON (24% abscesses) vs. Zn-AA (6% abscesses). NON had a greater incidence (P = 0.05; 50% abscesses) compared to CON. Overall, blood fibrinogen and leukocyte counts were not different between treatments (P \u2265 0.67); however, neutrophil-to-lymphocyte ratio tended to be greater in NON vs. CON (P = 0.08). Serum aspartate aminotransferase and gamma-glutamyl transferase concentrations were greater in NON vs. CON (P \u2264 0.02), and serum alkaline phosphatase concentration was lesser in CON vs. Zn-AA (P &amp;lt; 0.01). Overall, dietary Zn supplementation tended to lessen incidence of liver abscesses with limited impacts on overall cattle performance. Shifts in liver enzymes may represent opportunities to identify cattle with liver abscesses earlier in the feeding period.<\/jats:p>","DOI":"10.1093\/tas\/txad072","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T01:47:11Z","timestamp":1688089631000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of supplemental zinc on growth, carcass characteristics, and liver abscess formation in steers with experimentally induced ruminal acidosis challenge"],"prefix":"10.1093","volume":"7","author":[{"given":"Erika L","family":"Lundy-Woolfolk","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University Extension and Outreach , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia N","family":"Genther-Schroeder","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Branine","sequence":"additional","affiliation":[{"name":"Zinpro Corporation , Eden Prairie, MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,1]]},"reference":[{"key":"2023082810301571400_CIT0001","doi-asserted-by":"crossref","first-page":"306","DOI":"10.14202\/vetworld.2014.306-310","article-title":"Clinico-biochemical, ultrasonographic and pathological findings of hepatic abscesses in feedlot cattle and buffaloes","volume":"7","author":"Abdelaal","year":"2014","journal-title":"Vet. 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