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Sixteen (16) healthy, mature, light breed horses were randomly assigned to diets containing 0 or 120 mL (n\u2005=\u20058 per group) of ST-J for 30 d. On days 0 (prior to beginning supplementation) and 27, recombinant equine interleukin-1\u03b2 (reIL-1 \u03b2) (75 ng) was injected into the left or right intercarpal joint to induce mild, transient synovitis. Synovial fluid was obtained by aseptic arthrocentesis at postinjection hour 0 (immediately prior to IL-1 injection), 6, 12, and 72. ST-J supplementation for 30 d significantly increased synovial fluid nitric oxide, and resolvin D1 compared with the unsupplemented control group and significantly increased PGE2 levels and reduced joint circumference in the ST-J treated horses on day 30 compared to the same group of horses on day 0. There was also a significant increase in plasma hemoglobin, free and total bilirubin, and decrease in plasma glucose. These data provide evidence for the usefulness of ST-J to modulate physiological variables with importance in exercise performance and tissue adaptation to exercise stress and further research on this product is warranted.<\/jats:p>","DOI":"10.1093\/tas\/txae172","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:07:07Z","timestamp":1733872027000},"source":"Crossref","is-referenced-by-count":4,"title":["Effect of a dietary nutraceutical \u201cSTRUCTURE-Joint\u201d on response of horses to intra-articular challenge with IL-1: implications for tissue adaptation to stress"],"prefix":"10.1093","volume":"8","author":[{"given":"Lindsay","family":"Korac","sequence":"first","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Golestani","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-461X","authenticated-orcid":false,"given":"Jennifer","family":"MacNicol","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Souccar-Young","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Witherspoon","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arayih","family":"Wildish","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Topfer","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"2024122013343567200_CIT0001","doi-asserted-by":"publisher","first-page":"6366","DOI":"10.1002\/jcp.29607","article-title":"Role of iNOS in osteoarthritis: pathological and therapeutic aspects","volume":"235","author":"Ahmad","year":"2020","journal-title":"J. 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