{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T13:01:45Z","timestamp":1780146105910,"version":"3.54.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":130,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This experiment evaluated behavioral, physiological, and health responses of feedlot-adapted growing bulls administered the maternal bovine appeasing substance (mBAS; FerAppease, FERA Diagnostics and Biologicals; College Station, TX) at the time of castration. Angus-influenced (n\u2009=\u2009182) bulls were purchased from 3 sources with no previous health and management history, and transported to the research center on d \u221240. Bulls were assigned to initial processing and revaccination on d \u221236 and \u221212, respectively. Bulls were ranked by body weight (BW) on d \u221212 (284\u2009\u00b1\u20093\u2009kg) and source, and assigned to 1 of 26 pens (n\u2009= 7 bulls\/pen, 13 pens\/treatment) on d 0. Pens were randomly assigned to receive bulls administered 10-mL of mBAS or no treatment (CON) immediately prior to band-castration (d 0). The mBAS was applied topically on the nuchal skin area (5\u2009mL) and above the muzzle (5\u2009mL) and reapplied on d 14. Final BW was recorded on d 42, whereas feed intake and signs of bovine respiratory disease (BRD) were recorded daily. Hair samples from the tail-switch were collected on d 0 and 14. Subjective pain-related behaviors were evaluated daily from d 0 to 13 using 3-point scoring system (0\u2009=\u2009no pain, 1\u2009=\u2009moderate pain, 2\u2009=\u2009severe pain). Bulls were also fitted with an ear tag (CowManager, Agis Automatisering BV, Harmelen, The Netherlands) to record behavioral responses. No treatment effects were detected (P\u2009\u2265\u20090.41) for BW gain, feed intake, and gain: feed, whereas cattle administered mBAS tended to have greater (P\u2009=\u20090.08) final BW. Hair cortisol concentrations did not differ (P\u2009=\u20090.66) between treatments on d 0, but were less (P\u2009=\u20090.02) in mBAS cattle on d 14 (treatment\u2009\u00d7\u2009day; P\u2009=\u20090.04). Incidence of BRD signs and mean pain score were less (P\u2009\u2264\u20090.05) for mBAS cattle. Cattle administered mBAS spent less time (P\u2009\u2264\u20090.03) being not active on wks 1 to 4, spent more time (P\u2009\u2264\u20090.03) being highly active during wks 1 and 2, and spent more time (P\u2009=\u20090.03) ruminating on wk 3 (treatment\u2009\u00d7\u2009day; P\u2009\u2264\u20090.04). Liveweight gain from d 0 to 42 tended (P\u2009=\u20090.09) to be greater for mBAS pens, and final liveweight was greater (P\u2009=\u20090.05) in mBAS pens. Pens that received mBAS had greater (P\u2009=\u20090.05) final value and tended (P\u2009=\u20090.08) to have greater profit. Administering mBAS to feedlot-adapted bulls at the time of castration attenuated chronic stress, reduced behavioral expression of pain, decreased the incidence of BRD signs, and improved pen-based productivity during a 42-d post-procedural period.<\/jats:p>","DOI":"10.1093\/tas\/txag062","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:43:13Z","timestamp":1778240593000},"source":"Crossref","is-referenced-by-count":0,"title":["Maternal bovine appeasing substance administration at castration reduces stress, pain-related behavior, and respiratory disease in feedlot bulls"],"prefix":"10.1093","volume":"10","author":[{"given":"Martin","family":"Zinicola","sequence":"first","affiliation":[{"name":"Cowix , San Francisco, C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-3601","authenticated-orcid":false,"given":"Reinaldo F","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX, 77843,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Bollatti","sequence":"additional","affiliation":[{"name":"Centro Experimental de Nutrici\u00f3n Animal Biofarma , C\u00f3rdoba, C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramiro","family":"Andreola","sequence":"additional","affiliation":[{"name":"Centro Experimental de Nutrici\u00f3n Animal Biofarma , C\u00f3rdoba, C\u00f3rdoba,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"2026053008312366700_txag062-B1","volume-title":"Official methods of analysis","author":"AOAC","year":"2006","edition":"18th"},{"key":"2026053008312366700_txag062-B2","doi-asserted-by":"publisher","first-page":"4762","DOI":"10.3168\/jds.2017-13706","article-title":"Invited review: current perspectives on eating and rumination activity in dairy cows","volume":"101","author":"Beauchemin","year":"2018","journal-title":"J. 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