{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:50:09Z","timestamp":1791521409161,"version":"4.3.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":271,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Pig Improvement Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Post-weaning colibacillosis (PWC) is a leading cause of morbidity and mortality in nursery pigs, affecting a large proportion of individuals on affected farms, caused by intestinal pathogenic Escherichia coli (E. coli) (InPEC). Its control requires comprehensive control strategies, including measures to address multidrug-resistant E. coli strains and reduced susceptibility to disinfectants. This study assessed the clinical outcome in two pig lines with distinct genetic susceptibility to enterotoxigenic E. coli: a resistant line (Genotype A) and a susceptible line (Genotype B), following experimental challenge with F18 and F4 (K88) pathogenic E. coli strains. At 7\u2009d post-challenge, F18- and F4-challenged genotype B groups had lower body weight (\u22122.24\u2009kg and \u22120.77\u2009kg, respectively) and reduced average body temperature (\u22120.44\u2009\u00b0C and \u22120.28\u2009\u00b0C) compared with genotype A pigs. Genotype B pigs exhibited higher lethargy scores and greater loss of body condition compared with genotype A pigs. Following F18 and F4 challenge, genotype B pigs had 6.72-fold (95% CI 2.56\u201317.60) and 9.06-fold (95% CI 3.95\u201320.74) higher odds, respectively, of developing a diarrhea score 3 (liquid feces) compared to genotype A pigs. Genotypes A and B pigs shed the challenge strains after DPI 1; however, genotype B pigs challenged with F18 or F4 had increased odds of heavy shedding (score 4) compared with genotype A pigs, with odds ratios of 1.85 (95% CI 0.98\u20133.49) and 2.86 (95% CI 1.53\u20135.33), respectively. Marked distal jejunum and mild-to-moderate ileum colonization were observed in F18- and F4-challenged genotype B pigs, respectively, while no bacterial attachment was observed on genotype A pigs. Survival was significantly reduced (P\u2009\u2264\u20090.05) in F18-challenged genotype B pigs and showed a decreasing trend (P\u2009=\u20090.07) in F4-challenged genotype B pigs, while no mortality was observed in genotype A pigs. These findings support the potential use of genetically resistant pigs as a promising strategy to reduce the clinical impact of PWC and warrant further investigation under field conditions.<\/jats:p>","DOI":"10.1093\/tas\/txag148","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:46:10Z","timestamp":1790682370000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic resistance confers protection against clinical severity, intestinal colonization, and mortality in weaned pigs experimentally challenged with pathogenic F18 and F4 InPEC\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"10","author":[{"given":"Rodrigo C","family":"Paiva","sequence":"first","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucina","family":"Galina Pantoja","sequence":"additional","affiliation":[{"name":"Product Development, Genus PLC , Hendersonville, TN 37075,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Holl","sequence":"additional","affiliation":[{"name":"Product Development, Genus PLC , Hendersonville, TN 37075,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Poeta Silva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubia R","family":"Macedo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R","family":"Burrough","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip C","family":"Gauger","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan K","family":"Aljets","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo E","family":"Pi\u00f1eyro","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo N","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, IA 50011,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026100900162210000_txag148-B100","first-page":"73","article-title":"Presentation of postweaning Escherichia coli diarrhea in southern Ontario, prevalence of hemolytic E. coli serogroups involved, and their antimicrobial resistance patterns","volume":"66","year":"2002","journal-title":"Can. 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