{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T13:29:11Z","timestamp":1746538151640,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103646","P20GM103476"],"award-info":[{"award-number":["P20GM103646","P20GM103476"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Listeria monocytogenes is a facultative anaerobic foodborne pathogen capable of surviving harsh environments. Recent work has indicated that anaerobic conditions increase the resistance capability of certain strains to environmental stressors. The goal of the study was to conduct a preliminary study to determine whether exposure to anaerobic conditions prior to infection increases the ability to survive in vivo. Gerbils were inoculated with one of five doses of the L. monocytogenes strain F2365 by oral gavage: phosphate-buffered saline (control), 5 \u00d7 106 colony forming units aerobic culture (low aerobic), 5 \u00d7 108 aerobic culture (high aerobic), 5 \u00d7 106 anaerobic culture (low anaerobic), or 5 \u00d7 108 anaerobic culture (high anaerobic) dose of F2365. Gerbils inoculated with a high aerobic or anaerobic dose exhibited significant weight loss. Gerbils administered either the low or high anaerobic dose had at least 3 log10 of L. monocytogenes present in fecal samples, which contrasted with gerbils that received the low aerobic dose. Animals that received the high anaerobic dose had a significant increase in bacterial loads within the liver. Histologic examination of the L. monocytogenes positive livers exhibited locally extensive areas of hepatocellular necrosis, though the extent of this damage differed between treatment groups. Microbial community analysis of the cecum from gerbils infected with L. monocytogenes indicated that the abundance of Bacteroidales and Clostridiales increased and there was a decrease in the abundance of Spirochaetales. This study suggests that anaerobic conditions alter the localization pattern of L. monocytogenes within the gastrointestinal tract. These findings could relate to how different populations are more susceptible to listeriosis, as oxygen availability may differ within the gastrointestinal tract.<\/jats:p>","DOI":"10.1093\/tas\/txy110","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T18:33:08Z","timestamp":1538591588000},"page":"304-314","source":"Crossref","is-referenced-by-count":5,"title":["Oxygen deprivation influences the survival of Listeria monocytogenes in gerbils1"],"prefix":"10.1093","volume":"3","author":[{"given":"Jillian","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University, Mississippi State, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oindrila","family":"Paul","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Hong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Food Science and Center for Food Safety, University of Arkansas, Fayetteville, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally J","family":"White","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khemraj","family":"Budachetri","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M","family":"McClung","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University, Mississippi State, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica G","family":"Wilson","sequence":"first","affiliation":[{"name":"Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia K","family":"Olivier","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A","family":"Thornton","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University, Mississippi State, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R","family":"Broadway","sequence":"first","affiliation":[{"name":"USDA-ARS, Livestock Issues Research Unit, Lubbock, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C","family":"Ricke","sequence":"first","affiliation":[{"name":"Department of Food Science and Center for Food Safety, University of Arkansas, Fayetteville, AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet R","family":"Donaldson","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"2020051902194631700_CIT0001","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.gastro.2014.07.020","article-title":"Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota","volume":"147","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"key":"2020051902194631700_CIT0002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/1756283X12454590","article-title":"The intestinal microbiota dysbiosis and clostridium difficile infection: is there a relationship with inflammatory bowel disease","volume":"6","author":"Bien","year":"2013","journal-title":"Therap. 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